Dietary Polyphenols in Human Diseases：Advances and Challenges in Drug Discovery

"Diets rich in plant polyphenols or dietary polyphenols are the subject of increasing scientific interest because of having diverse range of health benefits and medicinal uses. The book titled "Dietary Polyphenols in Human Diseases: Advances and Challenges in Drug Discovery" is indented to fill the gap that exist in the current knowledge by presenting the latest information in the area/ topic of research interest. This book focuses on the current understanding of the beneficial effects of diets rich in polyphenols and/or polyphenolic compounds derived from dietary sources (plant-based foods) on human health and their possible preventive role in the management of chronic human diseases. In addition, biochemical mechanisms involved in the antioxidative effect of dietary polyphenols along with their bioavailability, pharmacokinetic, and toxicological considerations are also discussed herein. Key features : presents health benefits and medicinal importance of dietary polyphenols having antioxidative effects and their possible preventive role against oxidative stress (OS)-induced chronic human diseases, summarizes latest understanding on the biochemical mechanism(s) involved in the antioxidative action of dietary polyphenols along with their bioavailability, pharmacokinetic, and toxicological considerations, and highlights novel approaches of drug discovery from dietary polyphenols through computational screening of bioactive phytochemical components.With contributions by a global team of experts (academicians, scientists, and researchers), this book is intended to be a useful resource to a wider audience, particularly those working in the area of drug discovery and development research, such as discovery scientists, pharmaceutical scientists (R&D), formulation scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, clinicians, researchers, students, teachers, and many others"--