Chapter 1: A systemic view of metastatic disease: inter-organ crosstalk and therapeutic implications
PART I - Systemic Regulation in Metastatic Disease
Chapter 2: Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles
Chapter 3: Bone Metastasis: Systemic Regulation and Impact on Host
Chapter 4: Targeting Metastatic Disease: Challenges and New Opportunities
PART II - Cachexia: a Debilitating Systemic Effect of Cancer
Chapter 5: Signaling Pathways That Promote Muscle Catabolism in Cachexia
Chapter 6: The Role of Interleukin-6 Cytokines in Cancer Cachexia
Chapter 7: NF-kB Signaling in the Macroenvironment of Cancer Cachexia
PART III - Therapy-induced Muscle Wasting
Chapter 8: Therapy-Induced Toxicities Associated With the Onset of Cachexia
Chapter 9: Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy
PART IV - Preventing and Targeting Cachexia in Cancer
Chapter 10: New Developments in Targeting Cancer Cachexia
Chapter 11: Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer
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