This book explores sustainability and innovation in manufacturing, encompassing three distinct parts. The first section delves into Sustainability in Manufacturing, where it analyzes topics like intelligent manufacturing, Industry 4.0 challenges, structural equation modeling for social sustainability, barriers to intelligent manufacturing systems, and critical success factors in Six Sigma deployment. The second part of the book, comprising Chapters 6-11, focuses on Ergonomics and Safety in manufacturing, examining cases related to health issues caused by factors like noise, high-temperature working conditions, ergonomic posture, and design attributes for ergonomic products. Lastly, Part III, consisting of Chapters 12-14, explores computational techniques applied in manufacturing, addressing issues such as vegetable waste in India, technology transfer models for university-industry collaboration, and the application of System Dynamics in safety management systems. Together, these chapters provide a comprehensive overview of sustainability, ergonomics, safety, and computational techniques in the manufacturing industry.