We have organized this Special Issue to discuss the appropriate possibilities for skin reconstruction and regeneration. Luze et al. explained how antiseptic-loaded BNC represents a promising and effective approach for the treatment of biofilms. Korzeniowski et al. demonstrated how a bromelain-based enzymatic method offers a good, safe debridement option to improve the life quality of children with severe burns. Martinovic et al. wrote a paper titled "Objective Skin Quality Assessment after Reconstructive Procedures for Facial Skin Defects". An interesting technique was introduced by Woo Yoo et al.-a modified mini-keystone flap technique for covering tiny volar pulp defects of the fingertip, with few complications and favorable outcomes. Russo et al. conducted a comparative study between Connettivina Bio Plus and Fitostimoline Plus. They showed that both were secure and effective for treating acute superficial skin lesions. Hwan Kim et al. published "A Prospective Randomized Trial Comparing Paste-Type Acellular Dermal Matrix to Standard Care for the Treatment of Chronic Wounds". Korzeniowski et al. enriched the Special Issue with a systematic review titled "The Role of the Immune System in Pediatric Burns". Finally we presented the paper "Collection of Key Surgical Techniques for the Reconstruction of Midface Skin Defects" for the midface's significant role in defining important facial traits. Finally, I would like to express my sincere respect to all authors for submitting excellent papers, and to reviewers for taking the time to review them.
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