This book develops a conceptual and analytical framework for understanding persistent regional divergence in innovation performance. Instead of treating inequality as a measurable outcome, this book introduces the concept of structural asymmetry as an underlying mechanism embedded in knowledge capacity, institutional coordination, and opportunity structures. This book seeks to move beyond descriptive cluster studies and fragmented empirical cases by offering a transferable theoretical architecture that can be applied across national contexts. This book also examines how contemporary global transitions--such as digitalization, demographic change, and climate transformation--interact with pre-existing regional structures. By linking long-term divergence with institutional governance and emerging technological shifts, this book aims to provide both theoretical depth and policy relevance for scholars, graduate students, and practitioners concerned with regional innovation and structural transformation.
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