Genome-based Diagnostics

The sequencing of the human genome and the identification of associations between specific genetic variants and diseases have led to an explosion of genomic-based diagnostic tests. These tests have th

Oral-based diagnostics have the potential to detect systemic disease and evidence of exposure to various harmful substances, as well as provide biomarkers of health and disease status. Integration of

Etiology-Based Dental and Craniofacial Diagnostics explores the role of embryology and fetal pathology in the assessment, diagnosis, and subsequent treatment planning of a wide range of disorders in t

The most complete, up-to-date reference on antigen retrieval and immunohistochemistry An antigen is a substance that prompts the generation of antibodies and can cause an immune response. The antigen

What is knowledge? How can it be successfully assessed? How can we best use the results? As questions such as these continue to be discussed and the learning sciences continue to deal with expanding a

"On February 12, 2009, the Roundtable convened a workshop designed to address four central questions related to the development of systems to evaluate clinical use of health care innovations that stem

Targeted Genome Engineering via CRISPR/Cas9 in Plants provides in-depth insights into the use of the emerging "CRISPR/Cas9" technology for precise genome editing. This technology has revolutionized plant science research particularly for crop improvement owing to its simplicity and efficiency. Targeted Genome Engineering via CRISPR/Cas9 in Plants provides a wide range of CRISPR/Cas9 gene editing techniques for numerous varieties of plants. Chapters include the latest applications of CRISPR/Cas9 system in connection with abiotic stress, biotic stress, biofortification, yield improvement, disease modelling and prognosis and molecular diagnosis. This book also evaluates various regulatory and ethical aspects that must be considered when implementing the CRISPR/Cas9 approach. This book is a valuable resource for professionals and researchers, as it provides effective CRISPR/Cas9-based strategies for sustainable agriculture and treatment of infectious and non-infectious diseases.

This volume details cutting-edge methods that enables engineering of novel functions in mammalian cells. Chapters guide readers through cell-to-cell communication, cell fate control, protein and RNA-based biosensors together with tools for more reliable and faster mammalian genome editing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mammalian Synthetic Systems aims to ensure successful results in the further study of this vital field.

The advent of the CRISPR/Cas9 class of genome editing tools is transforming not just science and medicine, but also law. When the genome of germline cells is modified, the modifications could be inherited, with far-reaching effects in time and scale. Legal systems are struggling with keeping up with the CRISPR revolution and both lawyers and scientists are often confused about existing regulations. This book contains an analysis of the national regulatory framework in eighteen selected countries. Written by national legal experts, it includes all major players in bioengineering, plus an analysis of the emerging international standards and a discussion of how international human rights standards should inform national and international regulatory frameworks. The authors propose a set of principles for the regulation of germline engineering, based on international human rights law, that can be the foundation for regulating heritable gene editing both at the level of countries as well as

Dental implants are used routinely throughout the world to replace missing teeth. With the broadening of treatment options and an increasing number of clinicians that provide implant therapy, it is important to ensure that the treatment methods used meet the highest clinical standards. The ITI Treatment Guide series is a compendium of evidence-based implant-therapy techniques in daily practice. Written by renowned clinicians and supported by contributions from expert practitioners, the ITI Treatment Guides provide a comprehensive overview of the various indicated treatment options. The management of different clinical situations is discussed with an emphasis on sound diagnostics, evidence-based treatment concepts, and predictable treatment outcomes with minimal risk to the patient. Volume 13 of the ITI Treatment Guide series provides clinicians with the latest evidence-based information on the prevention and management of peri-implant diseases. This information is based in part on the

Recent observational results from space- and ground-based telescopes have demonstrated that a unified approach to the relationships between solar and stellar magnetism is necessary to advance our understanding of magnetic fields. The Proceedings of IAU Symposium 354 present recent results and discussions of emerging topics, including: magnetic field diagnostics using high-resolution observation; initial data from ALMA, Chinese Radio Spectroheliograph and other instruments; the detection of stellar magnetospheres; and the detailed mapping of magnetic fields on the surface of stars using new unique instrumentation. These observations stimulate comparisons of solar and stellar results, and improve our understanding of how surface magnetic structures and their evolution are related to the generation of magnetic fields by dynamos in solar and stellar interiors. This volume benefits graduate students and researchers interested in the recent advances and key problems of solar and stellar magn

The advent of the CRISPR/Cas9 class of genome editing tools is transforming not just science and medicine, but also law. When the genome of germline cells is modified, the modifications could be inherited, with far-reaching effects in time and scale. Legal systems are struggling with keeping up with the CRISPR revolution and both lawyers and scientists are often confused about existing regulations. This book contains an analysis of the national regulatory framework in eighteen selected countries. Written by national legal experts, it includes all major players in bioengineering, plus an analysis of the emerging international standards and a discussion of how international human rights standards should inform national and international regulatory frameworks. The authors propose a set of principles for the regulation of germline engineering, based on international human rights law, that can be the foundation for regulating heritable gene editing both at the level of countries as well as

Hippocrates famously advised doctors 'it is far more important to know what person the disease has than what disease the person has'. Yet 2,500 years later, 'personalised medicine', based on individual genetic profiling and the achievements of genomic research, claims to be revolutionary. In this book, experts from a wide range of disciplines critically examine this claim. They expand the discussion of personalised medicine beyond its usual scope to include many other highly topical issues, including: human nuclear genome transfer ('three-parent IVF'), stem cell-derived gametes, private umbilical cord blood banking, international trade in human organs, biobanks such as the US Precision Medicine Initiative, direct-to-consumer genetic testing, health and fitness self-monitoring. Although these technologies often prioritise individual choice, the original ideal of genomic research saw the human genome as 'the common heritage of humanity'. The authors question whether personalised medicine

Recent advances in genome editing tools using endonucleases such as TALENs, ZFNs, and CRISPRs, combined with genomic engineering technologies, have opened up a wide range of opportunities from applications in the basic sciences and disease biology research, to the potential for clinical applications and the development of new diagnostic tools. This complete guide to endonuclease-based genomic engineering gives readers a thorough understanding of this rapidly expanding field. Chapters cover the discovery, basic science, and application of these techniques, focusing particularly on their potential relevance to the treatment of cancer, and cardiovascular and immunological disease. The final section discusses the legal and ethical issues which accompany the technology. Providing authoritative coverage of the potential that genome editing and engineering have, this is an ideal reference for researchers and graduate students and those working in the biotechnology and pharmaceutical industrie

Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics Boron-Based Compounds offers a summary of the present status and promotes the fu