Model Systems in Aging

Aging is the progressive decline in biological functions over time. This decline targets macromolecules, cells, tissues and, as a consequence, whole organisms. Despite considerable progress in the dev

This state-of-the-art book discusses the role of free radicals in aging in different animal models, as well as the relevance of free radicals on age-related diseases and pathological conditions in hu

How biomedical research using various animal species and in vitro cellular systems has resulted in both major successes and translational failure.In Model Systems in Biology, comparative neurobiologist Georg Striedter examines how biomedical researchers have used animal species and in vitro cellular systems to understand and develop treatments for human diseases ranging from cancer and polio to Alzheimer’s disease and schizophrenia. Although there have been some major successes, much of this “translational” research on model systems has failed to generalize to humans. Striedter explores the history of such research, focusing on the models used and considering the question of model selection from a variety of perspectives―the philosophical, the historical, and that of practicing biologists. Striedter reviews some philosophical concepts and ethical issues, including concerns over animal suffering and the compromises that result. He traces the history of the most widely used animal and in

This book presents a diverse collection of chapters on basic research at the molecular level using Lepidoptera as model systems. This volume, however, is more than just a compendium of information about insect systems in general, or the Lepidoptera in particular. Each chapter is a self-contained treatment of a broad subject area, providing sufficient background information to give readers a sense of the guiding principles and central questions associated with each topic, in addition to major methodologies and findings. Comparisons with other major model systems are emphasized, with special attention given to the fruit fly, Drosophila melanogaster. Topics include: genetics, mobile elements, embryogenesis, silk gland and chorion gene regulation, hormone action, neurobiology, the immune response and engineered baculoviruses. Molecular and developmental biologists at graduate and researcher levels will find this book of great interest.

This textbook presents a proven, mature Model-Based Systems Engineering (MBSE) methodology that has delivered success in a wide range of system and enterprise programs. The authors introduce MBSE as t

This book bridges the current gap between the theory of symmetry-based dynamics and its application to model and analyze complex systems. As an alternative approach, the authors use the symmetry of th

This book highlights the potential advantages of using marine invertebrates like tunicates, echinoderms, sponges and cephalopods as models in both biological and medical research. Bioactive compounds

Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented

By becoming tough we preserve those physical and mental capacities that are degenerated by stress and by aging. The toughness model proposed in this book incorporates psychological research and neuros

This book constitutes the refereed proceedings of the 14th International Conference on Model Driven Engineering Languages and Systems, MODELS 2011, held in Wellington, New Zealand, in October 2011. Th

The demands of increasingly complex embedded systems and associated performance computations have resulted in the development of heterogeneous computing architectures that often integrate several type

This book is an excellent compilation of cutting-edge research in heterogeneous catalysis and related disciplines – surface science, organometallic catalysis, and enzymatic catalysis. In 23 chapters b

The book concentrates on heterogeneous catalysis, but extends well beyond the most obvious model system – the single crystal. The book builds upon increasing complexity into catalyst models – that is

Human Biological Aging will introduce the student to human aging from the level of macromolecules to organ systems. Age changes in proteins, DNA, polysaccharides and lipids are discussed relative to k

The present Model Law on Legal Aid in Criminal Justice Systems with Commentaries was developed by the United Nations Office on Drugs and Crime (UNODC).

This book provides a new perspective on emotion in artificial systems. It presents an insightful explanation of how emotion might emerge deep inside the systems, and emotional behaviour could be seen

A key way that behavioral ecologists develop general theories of animal behavior is by studying one species or a closely related group of species--''model systems''--over a long period. This book brin

Advances in Ecological Research is one of the most successful series in the highly competitive field of ecology. This thematic volume focuses on large scale ecology, publishing important reviews that

In his study, Mahdi Derakhshanmanesh builds on the state of the art in modeling by proposing to integrate models into running software on the component-level without translating them to code. Such so-

A comparison of the use of model systems and exemplary cases across fields in the natural and social sciences.

Authors Li and Zheng present readers with a comprehensive examination of distributed model predictive control (DMPC), it’s basic concepts, technologies, and implementation in plant-wide systems. The a

This book introduces and describes in detail the SEQUAL framework for understanding the quality of models and modeling languages, including the numerous specializations of the generic framework, and t

This collection on case-based reasoning in the natural- and human sciences showcases some ways that scholars think with small instances while en route, or not, to more general laws.

This volume describes novel and state-of-the-art approaches to solvingproblems arising in the domain of embedded real-time systems. It isbased on the GI-Dagstuhl research seminar MBEERTS (Modelling-Ba

Testing is the primary hardware and software verification technique used by industry today. Usually, it is ad hoc, error prone, and very expensive. In recent years, however, many attempts have been ma

In this book, the state-of-the-art fuzzy-model-based (FMB) based control approaches are covered. A comprehensive review about the stability analysis of type-1 and type-2 FMB control systems using the

Between longer life expectancies and declining birth rates, Europe’s elder population is growing into a sizable minority with considerable impact on nations, health systems, and economies—in other wor

The design, implementation and validation of avionics and aeronautical systems have become extremely complex tasks due to the increase of functionalities that are deployed in current avionics systems

Parkinsons disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of

The practice of Model-Based Systems Engineering (MBSE) is becoming more widely adopted in industry, academia and commerce; as the use of modelling matures in the real world, so the need increases for