A timely and topical survey of modern simulation tools and their applications in real-life drug discovery, allowing for better and quicker results in structure-based drug design.The first part of this
This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader
This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope bring
In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the developmen
As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with d
Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized la
From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed.
With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future.Divided in
Tailored to the needs of drug developers, this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessm
The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists.The authors provide more than a systematic overview of computational tools and kn
How can animal models contribute to the early drug development process, from target validation to lead profiling? Pharmaceutical industry experts discuss the opportunities for novel drug development a
Researchers in pharmacy, medical information, and other biological and medical specialties explore how therapeutic strategies are now targeting interactions between proteins, rather than just small mo
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largestpharmaceutical companies worldwide. The first cha
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.As such, it provides a ready reference on the principles a
Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development.The first part provides a basic understanding
In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessmentand prediction of ADMET properties. Although the p
By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel thera
A comprehensive and up-to-date overview, this is both a desktop reference and practical guide for virtual screening applications in drug discovery. Clearly divided into three major sections, the first
Opening with a general introduction on chemokine function and chemokine receptor biology, the handbook goes on to cover the known implications of these signaling molecules in human diseases, such as c
In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of asp
The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit
