Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Young readers can discover what life is like for children all around the world as they explore everything from food to family, and even learn how to say hello in many different languages.Young readers can discover what life is like for children all around the world as they explore everything from food to family, and even learn how to say hello in many different languages. They will see where it’s polite to slurp your food and bad manners to give the thumbs-up sign. They’ll learn where children travel to school by cable car, and even discover who sleeps on an oven bed at night! This fascinating look at the lives of children around the globe gives an important insight into the many differences to celebrate in our diverse, beautiful world.

How did a peanut farmer from a small town in Georgia become the 39th President of the United States? Find out in this addition to the #1 New York Times best-selling Who Was? series!Everyone was rather surprised when small-town farmer Jimmy Carter first announced that he’d be running for president in 1976. When Jimmy told his mother, she replied, “President of what?” But this former naval officer and governor of Georgia was ready for the role. Jimmy Carter went on to become one of America’s most beloved political figures thanks to his honesty, strong faith, and compassion. Even today, Jimmy Carter is still dedicated to helping Americans through his extensive work as a philanthropist. He and his wife, Rosalynn, volunteer with Habitat for Humanity, building houses for the less fortunate and inspiring others to a life of service. Who Is Jimmy Carter? details the entire life of Jimmy Carter, beginning with his 1924 birth in Plains, Georgia. Readers will learn about his life as a p

Sounds no human can hear, colours our eyes can't see, scents no one can smell. . .revealed in the amazing world of Invisible Nature!Discover how animals use these hidden senses and mysterious forces to survive and find out how we have learned to tap into their secret powers in our daily lives.

This hilarious, illustrated middle-grade sequel, combining the humor of Diary of a Wimpy Kid with the action of The Last Kids on Earth, follows a hapless warlock-in-training as he struggles to live up to his great and terrible destiny. Remember Wick? Son of the Dark Lord, heir to the throne of black and broken glass, and next in line to be the leader of the Grim World? Well, after a major spell gone wrong, he finds himself kicked out of his own castle and shipped off as an exchange student. As if Middle Ages School wasn't hard enough already! Follow Wick through the pages of his journal as he comes up with a genius plan to defeat his foes, achieve greatness . . . and maybe even make a new friend in the process.

The newest adventure in the bestselling Unicorn Rescue Society transports readers to the Himalayan mountains in Northern Pakistan! When Uchenna and Elliot's classmate publishes an article in the school newspaper about the Schmoke Brothers, Professor Fauna notices something alarming in a photo. Mounted on the wall of the Schmoke's living room is a single spiral horn that he's certain could have come from only one animal--a unicorn! To save these magical creatures--and to finally see a unicorn themselves--the Unicorn Rescue Society heads to the rugged mountains of Pakistan. Hena Khan, the critically acclaimed author of Amina's Voice, joins Newbery Honor-winner Adam Gidwitz for the Unicorn Rescue Society's most dramatic, action-filled mission yet!

ABOUT WHO WAS? WORKBOOK: SUMMER ACTIVITIESIt’s fun to learn the Who Was? way!The latest addition to this workbook series explores even more vocabulary and reading comprehension topics for curious kids and Who Was? fans alike.Fans of Who Was?, the #1 New York Times Best-Selling series, are sure to love this summertime-themed workbook filled with reading passages based on their favorite historical figures! The interactive writing prompts at the end of each passage make the educational material more engaging, and allow young learners to apply the vocabulary and reading comprehension skills they’ve been practicing in an exciting and creative way.With material that aligns with national Common Core Standards and is vetted by a top educational consultant, Who Was? Workbooks are designed to reinforce lessons introduced in the classroom in an accessible way for young learners everywhere.This workbook also includes stand-alone activities like crossword puzzles, fill-in-the-blank word games, and

Harry and Hedgehog celebrate Hedgehog's birthday!Pick a book. Grow a Reader!This series is part of Scholastic's early reader line, Acorn, aimed at children who are learning to read. With easy-to-read text, a short-story format, plenty of humor, and full-color artwork on every page, these books will boost reading confidence and fluency. Acorn books plant a love of reading and help readers grow!It's Hedgehog's birthday and Harry has the coolest present for his best friend -- a wind-up toy airplane! He hopes Hedgehog likes it. But when Harry arrives at Hedgehog's birthday party the worst thing happens: Harry spots the exact same airplane that he bought for Hedgehog! Will Hedgehog still like Harry's present? These sweet, laugh-out-loud friendship stories with full-color artwork, color-coded speech bubbles, and easy-to-read text throughout are perfect for new readers!

THE WORLD’S WORST PETS by David Walliams is #1 AGAIN on the Sunday Times Children's Bestseller List!BE WARNED! AWFUL ANIMALS LURK INSIDE... Millions of readers have loved The World's Worst Children, The World's Worst Teachers and The World's Worst Parents - now they will delight in this ludicrously laugh-out-loud collection of pets, brought to you by the phenomenal Number One bestselling author David Walliams, with every story illustrated in vibrant colour by Adam Stower. These ten tales of the world's craziest creatures will have you shaking with laughter.You'll never look at pets in the same way again! Marvel at Houdini, the magician's rabbit. Take a trip around the world with Zoom, the supersonic tortoise. Gasp at the chaos created by Griselda, a grizzly bear with a big secret.And RUN FOR YOUR LIVES! It's Furp, the monstrous goldfish! Good pets, bad pets, supervillain pets, pets as big as a house and pets that could eat you in one gulp - these are the most hilarious and horrendous a

紐伯瑞銀獎《A Wish in the Dark》作者以泰國為原型打造古老、奇異的海上冒險。前途備受矚目的製圖師助理得到遠征繪製地圖的機會，前往傳說中的島嶼。謊稱家世的她其實來自低下階級，秘密會在危機重重的旅途中被揭穿嗎？From Christina Soontornvat, the visionary and versatile author of two 2021 Newbery Honor Books, comes a high-seas adventure set in a Thai-inspired fantasy world.In a fantasy adventure every bit as compelling and confident in its world building as her Newbery Honor Book A Wish in the Dark, Christina Soontornvat explores a young woman’s struggle to unburden herself of the past and chart her own destiny in a world of secrets. As assistant to Mangkon’s most celebrated mapmaker, twelve-year-old Sai plays the part of a well-bred young lady with a glittering future. In reality, her father is a conman―and in a kingdom where the status of one’s ancestors dictates their social position, the truth could ruin her. Sai seizes the chance to join an expedition to chart the southern seas, but she isn’t the only one aboard with secrets. When Sai learns that the ship might be heading for the fa

Reveal the hidden science all around us! People use science every single day in their jobs, sometimes without realising! From a smoothie maker creating a vortex to blend fruit and vegetables to firefighters extinguishing a blaze by breaking the fire triangle, the jobs and occupations at the heart of this super-creative non-fiction read will inspire all children to seek out the everyday science in the world around us.

Reveal the hidden maths all around us! People use maths every single day in their jobs, sometimes without realising! From a football coach studying the stats to a chef making sure everyone's food is ready at the same time, the jobs and occupations at the heart of this super-creative non-fiction read will inspire all children to seek out the everyday maths in the world around us.

Bestselling author and illustrator Liz Pichon gives you a step-by-step guide to drawing the wonderful characters from her blockbuster Tom Gates series, and more! The must-have art activity book for fans of Tom Gates: a celebration of imagination and creativity, packed with how-to doodles, pictures to colour-in and things to make and do. Learn how to illustrate Rooster the dog and Tom's favourite snacks, how to design a bedroom like Tom's with your doodles on his walls, draw lots of facial expressions and much, much more! Over 5 million copies of the Tom Gates series sold in the UK! Leave boredom behind with this activity-packed book: hours of fun for kids. The perfect present for creative kids.ABOUT THE TOM GATE SERIES: Written in diary form Full of Tom's doodles and pictures & his amazing sense of humour This first title in the series, was the winner of the Roald Dahl Funny Prize! Perfect gifts for boys & girls who love to laugh themselves silly The first series of The Brillia

The Bad Guys are here again, in The Bad Box 2! Sure, they will save the world from ending, they get kidnapped by an alien with too many teeth, have a Jurassic misadventure, and they even get to join a league of superheroes! Do they face danger? Yes, always! But is it funny? Oh, yes, it is! When you are in bad company, it's all in a day's work for Mr. Wolf, Mr. Piranha, Mr. Snake, and Mr. Shark.The four titles are:Episode #5: Intergalactic Gas Episode #6: Alien vs Bad GuysEpisode #7: Do You Think He-Saurus Episode #8: Superbad

天剛亮，一對兄妹隨著科學家媽媽在婆羅洲的研究營地展開新的一天。從河上小船到濃密的叢林，他們記錄紅毛猩猩的行蹤，驚嘆雲豹的優雅，也忍受「世界最臭的花」的氣味。沿途，科學家們架設相機陷阱、觀察鳥類與昆蟲，並記錄下多樣的動植物。本書以漫畫分鏡結合知識解說，由牛津大學生態學教授 Owen Lewis 共同撰寫，讓讀者在輕鬆的閱讀中體驗野外調查的真實節奏與自然的奧妙。Join a brother and sister in Borneo as they help their mother and other scientists with their work in the jungle, and encounter orangutans, a very stinky flower and a clouded leopard. Find out what makes the jungle and the wildlife that lives there so special, and learn about the work being done to protect it. - Told in lively comic book style- Written in collaboration with Owen Lewis, Professor of Ecology at the University of Oxford, who has done extensive work in Borneo.- Perfect for school projects- Discover more books in the 24 hours in... seriesChapters in this book include:- Waking Up- Breakfast time- Around camp- To the boat and up the river- Into the jungle- Field notes: Biodiversity- Camera traps- Jungle bloodsuckers- A stinky surprise- Mist nets- Field notes: Birds- Cleo's entomology lab - Field not

This is Slappy's world -- You only scream in it The terrifying next installment in the Goosebumps SlappyWorld arc

The thrilling conclusion to the epic middle grade fantasy trilogy from Katherine Applegate, the New York Times bestselling and Newbery Award-winning author of The One and Only Ivan (now a major motion picture!), The One and Only Bob, Wishtree, and Crenshaw!In the beginning, Byx's original quest was to discover if there were more of her kind, or if she was destined to become an endling--the last dairne alive. She did indeed find more dairnes, and along the way she also created allies among other creatures in her world, including humans, felivets, raptidons, and wobbyks.But Byx and her new friends soon learned that it wasn't just dairnes in jeopardy of extinction, but that everyone was at risk. With the world in unprecedented danger, Byx must rally creatures of all kinds to lead a revolution.Katherine Applegate's Endling series has so far earned a collective five starred reviews, and each of the prior books has debuted on the New York Times bestseller list. She once again delivers an act

Join New York Times bestselling author Stuart Gibbs in this first book in a hilarious, highly illustrated new middle grade series about a peasant boy who wants to be a knight, perfect for fans of Max & the Midknights.Tim is just a peasant, but he dreams big. He wants more out of life than to grow up to be a woodsman like his father. Unfortunately, the only route to success in the kingdom of Merryland is to be born a prince. Still, Tim is determined. He is brave and clever and always tries to do the right thing―even though he rarely gets the credit for it. Then news spreads that Princess Grace of the neighboring kingdom has been abducted by the evil Stinx and Prince Ruprecht needs a legion of knights to join him on his quest to rescue her. Tim finally has the lucky break he's been waiting for, the opportunity to change his station in life. And even though he doesn't know how to ride a horse or wield anything more deadly than a hoe, he's going to do whatever it takes to make sure his

• The #1 New York Times best-selling series with over 15.1 million copies in print worldwide — now in full color• Soon to be a major motion picture from DreamWorks• Aaron’s Pig the Pug series and Thelma the Unicorn series have been published by Scholastic Asia• Other titles that have been published by Scholastic Asia include Don’t Call Me Bear, Busting, Piranhas Don’t Eat Bananas, and I Need a Hug!Mr. Wolf. Mr. Shark. Mr. Snake. Mr. Piranha. They're Bad Guys, everybody knows that.They're scary and dangerous and well … just BAD.But these guys want to be HEROES.And they're going to prove it by doing good deeds … whether you want them to or not.Buckle up for the funniest, naughtiest and coolest book you'll ever read — now in full color!

Vivi loves science! In this STEM-themed Level 3 I Can Read! title, Vivi and her friends visit the aquarium and are introduced to the concepts of density and buoyancy. A great choice for aspiring scientists, emerging readers, and fans of Andrea Beaty's Ada Twist, Scientist. Includes activities, a glossary, and a fun experiment to do at home. Vivi loves science--and experimenting! In this Level 3 I Can Read! title, Vivi and her classmates visit an aquarium and learn about the creatures living in the big display tank. But why do some fish swim while others bury themselves in the sand? Vivi will have to experiment to find out!The Loves Science books introduce readers to girls who love science, as well as basic concepts of science, technology, engineering, and math. This Level 3 I Can Read! explores swimming, sinking, floating, and density, and includes an experiment to try at home. A great pick for newly independent readers and an ideal companion to Cece Loves Science: Push and Pull and Li

亞馬遜五星推薦圖像小說系列Hilo全新集數。宇宙的時間軸神祕地遭到反轉，奇幻生物占領地球，Gina、DJ與機器人Hilo展開刺激、幽默的史詩冒險，尋找解救地球的重要關鍵。“An action-packed page turner with heart!”—Dav Pilkey, author of DOG MANYour favorite characters are BACK and on an EPIC quest to save the world in the newest book in the New York Times bestselling graphic novel series that kids and critics love!There’s a NEW Earth! The world’s timeline has been turned upside down, and now magical creatures are EVERYWHERE. Gina has to fix things—FAST!With DJ and HILO’s help, can Gina find the key to turn the world back to what it was? Find out in Hilo 8—a laugh-out-loud, action-packed adventure filled with epic battles! True friendship! Good jokes! Bad jokes! Giant (hilarious) monsters! Spoiled royals! Prophecies! Good! Evil! And much, much more!Series Overview: Hilo debuted in Fall 2015 and has become a bestselling kid and critic favorite, recognized in classrooms everywhere. Hilo 1-6 is the story of Hilo’s war with Razorwark. In Hilo 7-9, it’s fan favorite Gina’s tur

Kitty is a superhero-in-training with cat-like superpowers. She dreams of being just like her superhero mum one day, but she's still got a lot to learn. Join her for a series of enchanting adventures by the light of the moon with her faithful cat crew by her side.Kitty is on a camping holiday with her friend Ozzy. Just like Kitty, Ozzy is a superhero-in-training with owl-like superpowers. During their stay in Whitefern Wood, they meet a wary wildcat, desperately looking for her lost kittens.The trouble is, she doesn't trust humans at all. Kitty must earn her trust and then prove her worth as a superhero in training, by finding the kittens and saving the day. Kitty and the Woodland Wildcat is the ninth book in the Kitty series, featuring a charming main character, cat-packed exploits, and striking two-colour art on every page.

Oona and her friends face their ultimate challenge in the final installment of the graphic sci-fi fantasy series that’s Star Wars meets Avatar: The Last Airbender!In the epic conclusion to the 5 World

A joyful Geisel Honor-winning series! Join Ty on his imaginative adventures in Ty's Travels: Lab Magic, a My First I Can Read book by acclaimed author and illustrator team Kelly Starling Lyons and Nina Mata. Science exploration, imagination, and play are highlighted in this fun story, perfect for sharing with children 3 to 6.Ty and Corey love to visit the museum. When they step through the doors, they become scientists. They study bugs and hunt for fossils. They catch the wind. When Ty can't participate in a lab activity because of his age, he uses his big imagination at home. Discovering new things is so much fun!Join Ty on his science adventure in this My First I Can Read for beginning readers. With simple, rhythmic text and joyful, bright art, this My First I Can Read book, Guided Reading Level I, is perfect for shared reading with a child. Books at this level feature basic language, word repetition, and whimsical illustrations, ideal for sharing with emergent readers. The active, e

Meet Bessie Lee! The Teeny Houdini chapter book series from author Katrina Moore and illustrator Zoe Si begins with a simply magical story. The adventures of Teeny Houdini come in short, easy-to-read chapters full of hilarious illustrations--a favorite series for building confident readers!Bessie Lee might be the teeniest in her first-grade class, but with the tap-tap-tap of her wand, some glitter, and a little magic . . . she's going to dazzle the crowds to win the school talent show.But when a trick goes disastrously wrong, Rufus, the class hamster, disappears!Can Bessie find a way to bring him back in time? Or is Rufus truly gone forever?

NOW IN PAPERBACK: On an island nation in the Indian Ocean, the explorers venture through a vast underwater world and take part in a friendly robotics competition. But the tides of good fortune change quickly.Suddenly, Team Cousteau jumps into action to rescue a faculty member from the brink of disaster. Meanwhile, the team follows Cruz's mother's clues to a magnificent tomb and center of spirituality precariously perched on the side of a cliff. There, Cruz is confronted by a familiar foe who's determined to stop him from completing his most important mission of all: retrieving the final pieces of his mother's cipher. In this life-and-death showdown, Cruz witnesses the ultimate sacrifice and uncovers a hidden message that makes him question his own mortality.The paperback edition includes the same great content and back matter as the original hardcover.And don't forget to check out the other books in the series:Explorer Academy: The Nebula Secret (1)Explorer Academy: The Falcon’s Feathe

SOON TO BE A MAJOR MOTION PICTURE!"I wish I'd had these books as a kid. Hilarious!" -- Dav Pilkey, creator of Captain Underpants and Dog ManThey may look like Bad Guys, but these wannabe heroes are doing good deeds... whether you like it or not in this New York Times bestselling illustrated series.A MYSTERIOUS DOORWAY! (Sure, it’s in the grossest restaurant in the world, but that doesn’t make it any less mysterious. OK?) Behold! What lies beyond?! An evil centipede? An alternate universe? A few decent explanations? VRRRING! NING! NING! NING!Hey, was that a CHAINSAW?! Let’s see if you can read and run at the same time... GO! It's the Bad Guys' next adventure!

Discover how this vibrant Black neighborhood in upper Manhattan became home to the leading Black writers, artists, and musicians of the 1920s and 1930s.Travel back in time to the 1920s and 1930s to th

Prince Lucas and Clara meet a mysterious young goblin in this seventeenth magical adventure of The Kingdom of Wrenly series! Goblins are among the most mysterious creatures in the Kingdom of Wrenly. Known to be extremely dangerous and shrewd, goblins were stripped of their magical powers after being defeated by the wizards in the Goblin Battles. So when Prince Lucas and Lady Clara come face-to-face with a young goblin on a mission to save the wizards of Hobsgrove, they must decide who to trust before history repeats itself.

The Big Red Dog is hitting the big screen! It's a race through NYC in this graphic novel based on the new live-action Clifford movie.Emily Elizabeth is struggling to fit in at home and in school when

Book 8.5 in the New York Times and USA TODAY bestselling Keeper of the Lost Cities series delivers what fans of the series have been begging for! Told in an exciting new way, the saga continues with p

A Netflix Original series! The fourth book in the New York Times, USA Today, and Wall Street Journal bestselling series, with over 7 million copies in print!"Terrifyingly fun! Delivers big thrills and even bigger laughs."--Jeff Kinney, author of the #1 New York Times bestseller Diary of a Wimpy KidIt's the first winter after the monster apocalypse. For Jack and his buddies, that means sled catapults, epic snowball battles, and one monstrous Christmas celebration. But their winter wonderland turns dark when a villainess begins hunting them. And this villainess is different―she’s a human.When the villainess steals Jack's prized monster-slaying tool, the Louisville Slicer, he vows to get it back. But it won’t be easy. Jack and his friends soon discover that the Louisville Slicer is the key to a dark plan that threatens the entire world―and beyond...Told in a mixture of text and black-and-white illustration, this is the perfect series for any kid who's ever dreamed of starring in their own

Now a Netflix original series!The fifth book in the New York Times, USA Today, and Wall Street Journal bestselling series, with over 7 million copies in print!"Terrifyingly fun! Delivers big thrills a

You are about to embark on a dangerous adventure. With this game in a book, use the pop-out Survival Spinner to learn your fate as you face peril after peril in a wild, rugged landscape. You become lo

The seven kids who bonded in Mr. Terupt’s fifth-grade class are now in eighth grade, reunited with their beloved teacher, and vow to make the year as memorable as possible.Jeffrey, Alexia, Anna, Danie

The elements of the periodic table come alive in the first book in a stellar nonfiction comic series illustrated by Shiho Pate!From oxygen to hydrogen, carbon to plutonium,Animated Science: Periodic Tablemakes chemistry come alive! In this book you'll meet the building blocks of you, the world, and the universe and see how they come together to make everything you see, do, and use every day.With a narrative nonfiction text, kid-friendly information, and Shiho Pate's engaging illustrations, Animated Science: Periodic Table is a perfect introduction and ready reference, appealing and laugh-out-loud funny. Easily accessible for readers just learning the elements, with more interesting facts and details for older kids honing their knowledge.Great for all ages!

冒險圖像小說新篇章。鱷魚特務們又要再次出擊啦！但這次特務Brash卻陷入神秘的昏迷之中，總部便設計出替代品機器人特務來跟Mango 搭檔，他們是否能一起阻止在城市裡肆虐的巨大螞蟻呢？Will InvestiGators Mango and RoboBrash be able to solve this latest mystery in the hilarious adventure series perfect for fans of Dog Man?!This new mission has our sewer-loving secret agents bugging out in InvestiGators: Ants in Our P.A.N.T.S, the latest chapter in the hilarious adventure series from John Patrick Green.With agent Brash trapped in a mysterious coma, the technicians at S.U.I.T. have designed the ultimate replacement: RoboBrash! This high-tech replica has been programmed with all of the original Brash’s crime-fighting skills and knowhow—but it seems he’s got a few bugs in his system! Will Mango and his new partner be enough to stop the giant ants that are on a rampage in the city? Orchestrated by the spaced-out villain, Maestronaut, and Houdino, the dinosaur escape artist, it seems criminals are certainly upping the ANT-y!

This is Slappy's world -- You only scream in it!Judy Glassman lives with her brother, Kenny, and father, Noah, in a village at the foot of Evil Rock. Every winter, Kenny accompanies their dad up to th

New York Times best-seller Karina Yan Glaser brings everyone’s favorite Harlem family back in this poignant fourth novel in the “delightful and heartwarming” (New York Times Book Review) Vanderbeekers

Girl by day. Cat by night. Ready for adventure! This chapter book series is purrfect for newly confident readers who are looking for superhero stories.In Kitty and the Starlight Song, Kitty is preparing for the end of the year concert - her class will be singing a song in front of the whole school, and each one of them will have a line to sing as a solo. As a superhero-in-training with cat-like superpowers, Kitty can do all sorts of marvellous things, from jumping between roofs to catching thieves and recovering stolen treasures. As a superhero, Kitty is learning to be brave and to trust in her skills.But as a regular girl, Kitty isterrified to sing in front of everyone at school. She will need the help of her trusted cat crew to overcome her stage-fright. Kitty and the Starlight Song is the eighth book in the chapter book series about Kitty and her superhero adventures.With a charming main character, cat-packed exploits and striking two-colour art on every page, Kitty is the perfect p

You Choose meets Richard Scarry's What Do People Do All Day? Pick your perfect job by choosing from things you LOVE to do. Whether you want to make things, draw, write, be in charge, get messy, help people, solve mysteries, discover new things, be outside, work with animals, numbers or machines, or do something loud or quiet, there's something for everyone! So if you decide you want to be outside, then a surfing coach, conservation worker, photographer and tree surgeon are just some of the brilliant jobs you could choose. Or if you love working with numbers then perhaps a robot scientist or video games developer would suit you more? Whatever you enjoy, there's something for you! In this interactive and inspiring picture book for children aged 3+ years, jobs are arranged by interests, making it really accessible and engaging.The busy, charm-filled spreads show children 'at work' in an intriguing range of occupations. And it encourages creative thinking and aspiration in an empowering, i