Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

A funny comic with robots, monsters, and aliens-that's just right for second graders! Sam claims a monster ate his homework, the tub is full of alligators, and extraterrestrials have named their planet in his honor. But when Sam's exaggerations alienate his classmates, the tall tales escalate. Are robots really attacking his house? (Of course not! Sam made it up!) As in Aesop's classic "The Boy Who Cried Wolf," Sam's community rallies to help him out. And Sam learns how a big fib can have serious consequences. I Like to Read Comics(R) are perfect for kids who are challenged by or unengaged in reading, kids who love art, and the growing number of young comics fans. Filled with eye-catching art, humor, and terrific stories, these comics provide unique reading experiences for growing minds. I Like to Read Comics(R), like their award-winning I Like to Read(R) counterpart, are created by celebrated artists and support reading comprehension to transform children into lifelong readers. We hop

Math booster author David A. Adler and artist Ed Miller make pie charts easy-as-pie charts with this fun and vibrantly illustrated guide to data collection. For students, STEM topics don't always feel like a walk in the park. But what if they were more like a day at the fair? Follow Janet and Ben from the Ferris Wheel to the carousel as they use graphs and data collection to make decisions about their day. This is the sixteenth book in this duo's math picture book series. Combining elements of a graphic story with engaging and accessible nonfiction text, David A. Adler combines his well-established STEM know-how with Edward Miller's vibrant, high contrast art to take young readers on a wild ride through the world of bar graphs, pictographs, pie charts, and more!

Laughton Rees is back in the latest novel from the bestselling author of the Sanctus trilogy--this time, with a case that hits uncomfortably close to home and threatens the thing Laughton values most: her daughter.When a body with no head or hands turns up in the river Thames Forensic specialist Laughton Rees is called in to consult. But what at first seems to be a typical, if gruesome case, quickly turns personal when it becomes apparent the body has a connection to Laughton's past.Laughton is not ashamed of her youthful indiscretions-- after all, they led to the birth of her daughter Gracie, the person she loves most in the world--but when this new case unexpectedly leads to Gracie's father turning up in their lives again, Laughton is automatically wary.Shelby Facer is a dangerous man, formerly imprisoned for his involvement in an international drug trafficking ring, and no matter what Laughton once felt for him, she doesn't want him anywhere near Gracie. But when Shelby claims he ca

The Fry Guys can't wait to meet the dino nuggies in this laugh-out-loud early graphic novel for snack lovers of all ages who crave laughs and crispy comic chaoas. Long ago, fries and dino nuggies lived together in golden, crispy harmony--until the nuggies mysteriously vanished from the menu. But thanks to cutting-edge snack science, they're back, and ready to rule the all-new Fry-assic Park! Curly, Sweets, and Waffle are thrilled to meet these prehistoric legends, but not everyone is ready to welcome the nuggies with open cartons. Are these tasty newcomers a recipe for friendship or a deep-fried disaster? Packed with puns, snack attacks, and fast-food fun, Meet the Dino Nuggies is a laugh-out-loud graphic novel that's perfect for reluctant readers and fans of Dog Man, Pizza and Taco, and Narwhal & Jelly. This early reader graphic novel features: Easy-to-follow comic panels and design for kids starting their graphic novel journeyFull-color art on every page, bringing the Fry Guys' c

Post-medieval archaeology in the Nordic countries has experienced rapid growth since the late 1990s, driven by urban development and increasing recognition of the period's importance. This volume provides a comprehensive synthesis of recent research, focusing on the region's integration into European and global networks through shifting political borders, trade, and maritime connections. Research traditions vary across the Nordic countries, influenced by differences in legislation, funding, and methodologies. While Norway's Cultural Heritage Act excludes most post-medieval sites, Sweden's 2014 reform expanded legal protections. Denmark emphasizes regional studies, often conducted by museums, while Finland and Iceland use a hybrid model combining state and private sector research. This volume brings together contributions that not only discuss local phenomena but also place them within broader Nordic and European contexts, offering valuable insights into the development and future direc

Join Bluey and her friends and family in this colouring in sticker book!Bluey is having a great time with her family and friends in this activity-filled colouring in sticker book. Join the fun and complete the spot the difference, design your own ice cream flavours and enjoy lots of colouring in. Make sure you colour in the sticker design to bring it to life and then use them in the activities. Wackadoo!Don’t miss these other awesome Bluey books:Bluey: How to DrawBluey: Father’s Day FunBluey: Bluey and Bingo’s Fancy Restaurant CookbookBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

Discover Bluey and Bingo's favourite foods in this touch-and-feel booK!Bluey and Bingo love munching, slurping, crunching and chomping their favourite food. Join them in this touch-and-feel book and play with different food from their games. Touch the sticky duck cake, hold the squishy magic asparagus and stroke Unicorse’s bobbly broccoli. Nom-nom-nom.Don’t miss these other awesome Bluey books:Bluey: Keepy UppyBluey: Bluey and Friends Jigsaw BookBluey: Bluey’s Bedtime: A Tabbed Board BookBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun?collection of story, activity and novelty books that celebrate play.?

Language is integral to human doing, being, becoming and belonging, and its acquisition is naturally distributed in and across activity spaces over time. Different learning experiences form 'a dialectical unity', where one brings the others into existence, and the capacities fostered in one inform and transform those in the others. Thus, connected learning across time and space is fundamental to the coherence, relevance, and meaningfulness of language learning, yet is not given sufficient attention in second language education. Connected learning is particularly relevant in the GenAI era where learner-driven lifelong and lifewide learning is much emphasized. This Element hence conceptualizes the framework of connected language learning with technology, and discusses how the framework could be operationalized and implemented in teaching and learning. It further foregrounds four concepts in this learning framework - agential literacy, interest development, self-regulation support, and id

For readers of David Nicholls and Sally Rooney comes a new love story that's at once tender and electrifying—told by everyone but the main characters. When Clara and Seb first cross paths in a London square, it’s the start of something exciting. Clara, an aspiring director stuck in an entry-level job, itches to pick up a camera. Seb, having floated between music, modeling, and now acting, struggles to find purpose in his work. Yet as random chance brings the two back together, time and time again, neither could predict that their magnetic connection is set to change their lives.But everyone else does. The spark between Clara and Seb is exactly what falling in love should look like: exhilarating, passionate, undeniable. The two become a whirlwind, their relationship enthralling everyone they come across. But as the years go on and tensions flair, a last-ditch attempt to save their great romance ends with a gut-wrenching betrayal.Set over the course of two decades, Clara and Seb’s love s

Prevailing classification systems backed by the American Psychiatric Association (DSM) and World Health Organization (ICD) generally assume that mental health conditions are best represented by discrete entities that are qualitatively distinct from one another and from mental health. These diagnostic categories, such as major depression, antisocial personality disorder, and obsessive-compulsive disorder, are ubiquitous in research, clinical, training, legal, and public health contexts. Yet they are out of sync with a vast quantity of scientific data on the presentation, causes, and treatments of psychopathology. Empirically speaking, categorical diagnoses tend to be unreliable (over time and across reporters), have fuzzy boundaries with one another and mental health, do not capture many clinical presentations encountered in routine practice, and lack distinctive causes and recommended treatments. Dimensional perspectives recognize the same signs and symptoms as categorical rubrics, but

In this debut collection of essays and poetry, musician, speaker, and activist Propaganda inspires us to create a better, more equitable world."If we get to make the very cultures that shape who we are, then let us remake them in the best way possible."In this deep, challenging, and thoughtful book, Propaganda looks at the ways in which our world is broken. Using the metaphor of terraforming--creating a livable world out of an inhospitable one--he shows how we can begin to reshape our homes, friendships, communities, and politics.In this transformative time--when we are redefining what a truly just and equitable world looks like, and reflecting on the work that needs to be done both in our spiritual and secular lives--Propaganda rallies readers to create that just world. He sheds light on how nefarious origin stories have skewed our views of ourselves and others and allowed gross injustices, and demonstrates how great storytelling and excellent art can create and shape new perspectives

SHE'S "MAID" FOR THIS!It’s time for the school festival at Royal Academy, and what could be more fun than a maid café? Lovely ladies in uniform, royalty in dashing butler’s garb—Luciana’s class is buzzing with excitement over the prospect. What’s more, Melody gets to put her maidly expertise to use as she helps with the preparations. From costuming to table setting, she’s got it covered! But a dark shadow falls over everyone’s good cheer as Christopher’s corruption arc begins, and the dark forces possessing him want blood. Will Melody and her maidly magic be enough to save the day?Series Overview: "I will become the world's most wonderful maid!" With her skirt fluttering in black and white, the girl shouted. Her name is Melody. A reincarnated former Japanese girl, she now pursues her dream in her new life, working as an all-purpose maid for a poor count's family in the kingdom of Théolas. When she makes it, even cheap tea turns into a luxury brew, and a dilapidated mansion is quickly r

The MoI had a global impact during the war and its work has reverberated in British culture ever since, from Orwell's Nineteen Eighty-Four to memes based on the slogan 'Keep Calm and Carry On'. The book discusses the development of the Ministry, those who worked for it, and the many audiences it addressed, both in Britain and internationally.

Join Bluey and her friends in this fun story with six jigsaw pieces to play with!Bluey and her friends are having fun together. Follow the story, find Bluey's friends and then put together the jigsaw pieces to make a special picture.Join Bluey and her friends in this fun story with six jigsaw pieces to play with!Don’t miss these other awesome Bluey books:Bluey: A Jigsaw Puzzle BookBluey: A Big Pop-Up BookBluey: Puppets: Starring UniverseBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

ALWAYS WATCH YOUR BACKThe Mogor Empire has gone on the march in a bloodthirsty campaign for conquest. Cale rallies his companions to fend off the imperial army’s advance, playing politics even as he plots the Empire’s downfall. But his plans hit a snag when he’s forced to choose between going all-out to crush the enemy or maintaining his carefully crafted reputation. Then, in a shocking twist, the Empire unveils its horrific secret weapons—the product of the alchemists’ inhumane experiments. If Cale and his allies have any hope of beating them, they’ll have to break free of their constraints and reach new heights of power!Series Overview: Ever dreamt of waking up inside a novel? For Kim Roksu, this dream becomes reality when he finds himself in the shoes of Cale Henituse, the lazy, wine-loving son of a count—and punching bag for the novel’s destined hero. Determined to dodge his grim fate, this new Cale Henituse vows to rewrite his story, aiming for a life of leisure far from heroic de

A Good Girl's Guide to Murder meets Fargo - In Case I Go Missing is a twisty thriller set in a small town with dark secrets that will keep you guessing until the final page.In Case I Go Missing, the debut YA thriller from R. N. Swann, is a twist-filled small-town mystery. Perfect for fans of The Reappearance of Rachel Price.Fenny has been the Watson to Sarah's Sherlock for as long as she can remember. Over the years, Sarah has ruffled a few feathers in their small town as an amateur detective and vigilante.Now, she's disappeared. The police have written her off as a runaway - but when Fenny discovers the binder Sarah left behind with a disturbing title, In Case I Go Missing, she knows there's foul play. Sarah was investigating her biggest mystery yet, one so explosive it had the power to shake the town to its very foundations.So Fenny picks up the case, following a trail of clues leading back to the dark, secret past of her home. How far did her suspects go to keep the truth buried?Rea

Get ready for bedtime with Bluey and Bingo in this tabbed board book!Get ready for bedtime with Bluey and Bingo in this colourful board book with 8 tabs.To join the fun, pick a tab, open the page and copy the game Bluey and Bingo play to help get them ready for bed. Games include Magic Asparagus at dinner, Burger Shop in the bath and the Story Game at bedtime."Night Bluey, night Bingo, night Floppy.""Night Chickenrat."Don’t miss these other awesome Bluey books:Bluey: Meet Bluey’s Family: Tabbed Board BookBluey: Bluey and Bingo’s Book of Singy Things: Tabbed Board BookBluey: SleepytimeBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelt

自然發音拼讀系列Phonics Step-By-Step 6：R-Controlled Vowels 《Phonics Step-By-Step 6: R-Controlled Vowels》為自然發音拼讀系列第六冊。此冊的 R-Controlled Vowels (R 控制的母音) 是以受 R 控制的母音為主軸，當母音 a、e、i、o、u後面接上子音 r 時，子音 r 會影響母音的發音，如： ar、er、ir、or、ur 等音組。這些音組也會有長音〔ɝ〕以及短音〔ɚ〕的不同發音，透過反覆的音組練習，學習者可以快速領略自然發音讓你輕鬆說英文的樂趣。 自然發音拼讀系列Phonics Step-By-Step 7：Gliding Blends and DIgraphs 《Phonics Step-By-Step》自然發音拼讀系列第七冊 Blends and Digraphs以混合及複合子音為主軸。混合子音包括 l、r、s 的雙子音混搭音組 (l-blends、r-blends、s-blends) 如 bl, br, sw 等，以及加入子音的混搭音組如 shr、str、spl、tw 等，都須拼讀及發出每個子音的聲音。而複合子音的音組如 ch、sh、th、ph、wh、ng、nk 等，都只能發出一個聲音。特定複合子音組合，還會產生特殊讀音。透過本書強化學習者自然發音能力，輕鬆說英文。 自然發音拼讀系列Phonics Step-By-Step 8：Gliding Blends and DIgraphs 《Phonics Step-By-Step》自然發音拼讀系列第八冊Special Sounds and Syllables，以特殊發音、音節、尾音、縮寫為主軸，包括認識 y、c、g 等子音的特殊發音；dge、gh、gn、kn、mb、tch、wr 等音組則會省略部分子音發音；還有常見的尾音 ed、s、es、ing；以及常用的英文縮寫。從基本發音，進一步到詞句、文章閱讀，幫助學習者有效練習自然發音。 英語進階學套組 自然發音法是從基礎的26個字母到特殊發音，一步一步的循序漸進讓你練習英語口說。 本套為自然發音法的進階內容，讓你輕鬆學習英文，有效練習發音。 【Phonics Step-By-Step】自然發音拼讀系列 Phonics Step-By-Step系列專為英文初學者打造，以英

如果有一天變成熊，你會做什麼？在本書中，「我」一早醒來，吃早餐、騎摩托車，還順手拯救被熱氣球帶走的好朋友——這些都是再正常不過的「熊日常」。當然，不可能站在全班面前做一份無聊又詳盡的熊類報告吧？Corey R. Tabor 以第一人稱視角巧妙鋪陳，讓讀者彷彿成了那隻熊，畫面邊緣還能看見熊的手腳晃動，幽默感十足。故事在出其不意的轉折中揭露真正的說話者，也溫柔回應孩子對上台報告的緊張。曾獲 Caldecott Honor 與三座 Geisel Award 的作者，再次帶來兼具創意與笑點的圖畫書。Assignment: Imagine yourself as a bear for the day. What would you do? Caldecott Honor and three-time Geisel Award–winning author and illustrator Corey R. Tabor offers an inspiring—and surprising—answer in this funny picture book for fans of Mo Willems, David Shannon, and Peter Brown.If you were a bear for a day, what would you do? Probably wake up, eat breakfast, go for a motorcycle ride, and rescue your best friend from a rogue hot air balloon. . . . You know, normal bear stuff!You certainly wouldn’t stand in front of the whole class and give a boring, detailed, and informational report about bears.Dynamically illustrated from the bear’s perspective, the Caldecott Honor and three-time Geisel Award–winning Corey R. Tabor delivers an innovati

For fans of My Dark Vanessa and Acts of Desperation, THE CRUSTACEAN is a Korean high schooler's response to Lolita'THE CRUSTACEAN isn't a novel, it's an obsession . . . I would kill and die for this book' ALISSA NUTTING, author of TAMPA'MY DARK VANESSA meets EARTHLINGS. A truly unique gut-punch of a read' Alice Slater, author of DEATH OF A BOOKSELLER"When I was 13 I knew nothing about anything.I only cared about love.And the older man, who I thought I fell in love with, never told me he was divorced.I made that up on my own."Chichirim is an ordinary, misunderstood, lonely schoolgirl. She's also in possession of a terrible secret.Her dad is worse than useless. And her mum spends all her days tattooing thick ugly eyebrows on old women.Her sister hates them so much she wishes they were dead.Chichirim does bad things at school. And still, no one cares.Until, one day, an older man picks her up on the side of the road.He tells her she is pretty.Her tells her what to do.Underneath her hard ou

Move the slider mechanism to answer funny questions about baby farm animals and lift five flaps to find hidden creatures! Explore farm life in this interactive and playful board book, which places the child at the centre of the action. Each spread is packed with fun and includes an engaging question about the scene. Decide and slide to choose your answer! Inside you’ll discover: Six multiple choice questions explore different farm scenes.Vibrant, bold and funny illustrations from Susie Hammer will keep little ones entertained and engaged. A multi-sensory reading experience, with a slider and flaps to lift. Spot the Quizzy Bean characters on each spread and lift the flaps to find out who’s hiding. Encourages active engagement and interaction, and helps children to express their knowledge and preferences. Each title in the series explores key Early Years concepts across the questions, for example: shape, colour or size. From Rebecca Atkinson – best known for pre-school series Mixmups, wh

Move the slider mechanism to answer funny questions about the home and lift five flaps to find hidden creatures! It's bedtime in this interactive and playful board book, which places the child at the centre of the action. Each spread is packed with fun and includes an engaging question about the scene. Decide and slide to choose your answer! Inside you’ll discover: Six multiple choice questions explore different rooms in a house.Vibrant, bold and funny illustrations from Susie Hammer will keep little ones entertained and engaged. A multi-sensory reading experience, with a slider and flaps to lift. Spot the Quizzy Bean characters on each spread and lift the flaps to find out who’s hiding. Encourages active engagement and interaction, and helps children to express their knowledge and preferences. Each title in the series explores key Early Years concepts across the questions, for example: shape, colour or size. From Rebecca Atkinson – best known for pre-school series Mixmups, which airs

Meet Izzy the Inventor in a laugh-out-loud series that brings together science, magic and a very lovable unicorn. Packed full of illustrations and easy-to-read text, this series is perfect for beginner readers and fans of Isadora Moon and The Naughtiest Unicorn.It's time for the school cooking competition and Izzy and her sister, Bella, are having an argument about the best way to build a cake tower, when Henry the Unicorn arrives with BREAKING NEWS: the TOP FIVE FAIRYTALE PRINCESSES have been kidnapped. Izzy and Henry must use their science skills to track down the princesses in Fairytale Land. Along the way, Izzy learns the secret to an excellent cake tower and, more importantly still, the power of sisterhood.Every book contains ideas for science experiments and a QR code with links for more to try at home.Collect all the books in the series!Izzy the Inventor and the Curse of DoomIzzy the Inventor and the Time Travelling GnomeIzzy the Inventor and the Teeny-Tiny OgresIzzy the Invento

How exactly did technical expertise come to be a central tenet to the work of international organisations? The Technocratic International reconstructs the neglected history of expert mobilisation at early moments of institutionalised international cooperation in the nineteenth century.

Explore a colorful home in this interactive and playful board book, which places the child at the center of the action. Move the slider mechanism to answer funny questions about the home, and lift the flaps to find hidden creatures!Each spread is packed with fun and includes an engaging question about the scene. Decide and slide to choose your answer! Features: Six multiple choice questions explore different rooms in a houseVibrant, bold and funny illustrations from Susie Hammer will keep little ones entertainedA multi-sensory reading experience, with a slider and flaps to liftSpot the Quizzy Bean characters on each spread and lift the flaps to find out who's hidingEncourages active engagement and interaction, and helps children to express their knowledge and preferencesEach title in the series explores key Early Years concepts across the questions, for example: shape, color, or size. From Rebecca Atkinson and Susie Hammer, this entertaining series is perfect for preschoolers to develo

Explore farm life in this interactive and playful board book, which places the child at the center of the action. Move the slider mechanism to answer funny questions about baby farm animals, and lift the flaps to find hidden creatures!Each spread is packed with fun and includes an engaging question about the farm. Decide and slide to choose your answer! Features: Six multiple choice questions about different farm scenesVibrant, bold and funny illustrations from Susie Hammer will keep little ones entertained and engagedA multi-sensory reading experience, with a slider and flaps to liftSpot the Quizzy Bean characters on each spread and lift the flaps to find out who's hidingEncourages active engagement and interaction, and helps children to express their knowledge and preferencesEach title in the series explores key Early Years concepts across the questions, for example: shape, colour or size. From Rebecca Atkinson and Susie Hammer, this entertaining series is perfect for preschoolers to

Elmo and the pet rock Rocco star in a Funko Pop!Sesame StreetLittle Golden Book!Young children, as well as Sesame Street fans and Little Golden Book collectors of all ages, will delight in reading about the funny ongoing feud between Elmo and Zoey’s pet rock, Rocco, in this Little Golden Book illustrated in the iconic Funko Pop! style.Sesame Workshop, the nonprofit educational organization behind Sesame Street, aims to help kids grow smarter, stronger, and kinder through its many unique domestic and international initiatives. These projects cover a wide array of topics, which address specific needs, such as girls' education, financial empowerment, and autism. Sesame Street is the most trusted name in early learning.Little Golden Books enjoy nearly 100% consumer recognition. They feature beloved classics, hot licenses, and new original stories. . . the classics of tomorrow.

Commemorate the innumerable ways the African American community has shaped the foundation of the United States in this stunning, poetic picture book from the Caldecott Honor-winning team behind Freedom in Congo Square.Black hands molded clay, chiseled marble,rendered portraits, and painted vistas.Black hands penned literary testamentsthat have stood the test of time.Since the United States won independence in 1776, African Americans have contributed greatly to the nation’s culture, politics, economy, and landscape. Black Hands celebrates the countless contributions of African Americans—from building the White House, birthing jazz, and landing a man on the moon to pushing for social justice. Black excellence, however, has too often been overlooked.Black Hands reunites Newbery Honor winner Carole Boston Weatherford and Coretta Scott King award-winning illustrator R. Gregory Christie to chronicle the remarkable progress of African Americans, even in the face of adversity.

Strong Bridges is a book about a contradiction and the opportunity it offers. For decades, social network theory has drawn its maps of advantage from the idea that brokers sit astride structural holes, reaping value from weak ties that bridge disconnected worlds. But what if some of those bridges are not weak? What if the real advantage lies not just in structure, but in trust forged in interpersonal history regardless of structure? This is the puzzle Strong Bridges takes up. It begins with guanxi, the colloquial Chinese term for relationship advantage, often dismissed as cultural peculiarity or corruption. But the authors treat guanxi as a strategic research site, not a cultural relic. They view it a niche-word pointing to a broader category of human experience. Combining analytic rigor with quality network data, they pull apart the Siamese twins of tie strength and network structure, documenting the prevalence and competitive value of high-trust ties that span structural holes, i.e.,