Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Wednesday Addams joins forces with her new roommate to win the Poe Cup in this Step 3 Step into Reading leveled reader based on the hit TV series Wednesday! Wednesday is a sleuthing, supernaturally infused mystery charting Wednesday Addams' time as a student at Nevermore Academy. But Wednesday Addams also insists on fair play, so she reluctantly joins forces with her far-too-cheerful roommate Enid Sinclair in an effort to win the prestigious Poe Cup and best her cheating rival Bianca Barclay in this Step Into Reading Step 3 leveled reader based on the dark world of the Wednesday TV series.Step 3 Readers feature engaging characters in easy-to-follow plots about popular topics. For children who are ready to read on their own.

本書是在《數據分析與EViews應用（第3版）》基礎上修訂而成，緊密圍繞IHS公司2022年推出的EViews 13.0版本展開，系統介紹其在數據處理、圖形呈現、計量分析與統計建模等方面的多項新增與優化功能。本書特色鮮明，突出體現為以下三點：一是新版本、新功能全覆蓋。詳細解析EViews 13.0在界面設計、與R/Python的兼容性、VAR模型、貝葉斯時變係數VAR、Johansen協整檢驗、非線性ARDL估計等方面的核心改進，幫助讀者直接掌握前沿工具。二是立足中國數據，服務實際問題。本次修訂特別選用我國宏觀、中觀及微觀實際數據更新案例，使學習過程更貼近國內現實情境，助力讀者提升運用數據分析和解決實際經濟問題的能力。三是內容詳略得當，側重操作應用。除介紹描述統計、回歸分析、時間序列等基礎方法外，本書深入講解了條件異方差、面板數據模型、狀態空間模型及混頻數據處理等複雜計量模型，並新增因子分析章節，通過詳盡的操作說明，力求使讀者在理論學習與軟件實踐中獲得全面提升。

本書是根據教育部高等學校大學數學課程教學指導委員會的總體要求、結合地方財經類專業需求特點編寫的。秉持“以價值塑造為根本、實踐應用為導向、數學素養提升為目標”的設計思路，量身定制課程內容，突出經濟數學的“經濟”特色。內容編排儘量做到結構合理、概念清楚、條理分明、深入淺出、強化應用。全書共分9章，涵蓋隨機事件及其概率、隨機變量及其分佈、隨機向量、隨機變量的數字特徵、大數定律與中心極限定理、抽樣分佈、參數估計以及假設檢驗等內容。為開拓學生的學習視野、增強實踐應用能力，本書在第9章中介紹了R語言及其在概率統計中的應用。為了便於讀者鞏固所學知識，每節後均附有習題，每章後附有總複習題，書末附有答案。本書既可以作為普通高等學校經管類本科生概率論與數理統計課程的教材，也可以作為教師的教學參考用書和全國碩士研究生統一入學考試的複習用書。

中國非洲研究院系根據習近平總書記重要指示精神成立，肩負著促進中非人文交流、深化中非文明互鑒的重要使命。作為中國非洲研究院的院刊，《中國非洲學刊》秉持學術性、創新性和開放性的原則，刊發國內外關於非洲的研究和中非關係研究的高質量學術論文，擬以中、英兩種文字在海內外出版發行。目前英文刊是以書代刊形式，已出版三輯，現在擬出版第四輯。本期Chinese Journal of African Studies (Volume 4 Number 1 October 2025),《中國非洲學刊》(英文版)以“China-Africa Cooperation and Development from the Perspective of the Global South(全球南方視域下中非合作與發展)”為選題和副書名，包括九篇文章。其中四篇文章的作者是非洲專家學者，曾參與我國外交部、中國非洲研究院等機構組織的來華調研活動，切身體會到在習近平新時代中國特色社會主義思想指導下的新時代中國飛速發展，並致力於將中國的先進思想和優秀經驗傳播到非洲國家，寫出“習近平治國理政思想對非洲發展的啟示”系列文章。另外五篇文章的作者是中國學者，其中一篇是本領域頂尖學者專門針對全球南方專題的約稿文章，四篇是已經發表在中文期刊上的文章，翻譯成英文。

在人工智能與數字化技術深度融合的時代背景下，傳統科層制組織的局限性日益凸顯，本書旨在系統回應這一挑戰，為構建面向未來的新型組織提供框架與路徑。本書圍繞一個名為“FRAME”的核心進化框架展開，該框架涵蓋五大關鍵路徑：靈動組織(F)、共鳴領導(R)、敏捷方法(A)、心流文化(M)與動態知識(E)。書中詳細定義了每條路徑從“傳統組織”到“超級組織3.0”的四個演進階段，並輔以代表性企業的實踐案例與核心觀點，為讀者描繪出一張清晰的組織進化地圖。本書具有強大的實踐指導性。它不僅構建了理論模型，更提供了包括“組織自檢表”在內的實用診斷工具，幫助管理者精准定位組織在各路徑上的發展階段。同時，本書提出了基於“木桶理論”的補短板進化策略，並明確了五大路徑的優先推進順序，為組織從現狀診斷到穩步進化提供了一套完整的、可操作的方法論。

1.本書內容涵蓋醫學統計學和醫學科研方法學，包括數據管理與常用軟件實現方法、醫學科研資料的統計描述、總體參數的估計與基本假設檢驗方法、相關與回歸方法、多元統計方法、生存數據分析方法、健康醫療大數據的分類診斷、因果推斷建模方法，以及醫學科研設計方法及常用樣本量估算方法、醫學科研數據的綜合分析及結果展示方法等內容。2.列出了SPSS軟件、R軟件、PASS軟件等操作過程，並進行詳細說明，使用者只需根據科研實際需求，對照方法實現醫學科研數據的計算，使學習統計學、應用統計學變得簡單、實用、高效。3.附錄部分列出了實際案例分析，製作數字內容，包括練習相關數據，採用二維碼形式，方便學習使用。

Award-winning author/illustrator Don Brown explores the history of rocket building in this installment of the Big Ideas That Changed the World graphic novel series. "That's one small step for man, one giant leap for mankind." On July 20, 1969, Neil Armstrong said those iconic words when Apollo 11 landed on the moon. But it wasn't just one man who got us to the moon--there was a whole team of people, plus centuries of discoveries and technologies that came before that made it possible. From ancient Chinese rockets to the first steps on the moon, Rocket to the Moon! Reveals which "bombs bursting in air" inspired the writer of "The Star-Spangled Banner," why the Russians wanted to launch a dog into Earth's atmosphere, and how exactly astronauts are able to go to the bathroom while in a rocket far off in space! Big Ideas That Changed the World is a graphic novel series that celebrates the hard-won succession of ideas that ultimately changed the world. Humor, drama, and art unite to tell th

It’s Greg’s birthday—and you’re invited to the chaos. In Partypooper, the 20th book in Jeff Kinney’s global smash-hit Diary of a Wimpy Kid series, Greg Heffley is planning the ultimate party—for himself.But when the guest list grows, the decorations flop, and the surprises backfire, this birthday bash turns into a total blowout—just not the kind Greg had in mind.Packed with cake disasters, family fiascos, and classic Wimpy Kid humor, this book is perfect for readers ages 8–12.Collect all the books in the #1 bestselling Diary of a Wimpy Kid series: Diary of a Wimpy Kid (#1) | Rodrick Rules (#2) | The Last Straw (#3) | Dog Days (#4) | The Ugly Truth (#5) | Cabin Fever (#6) | The Third Wheel (#7) | Hard Luck (#8) | The Long Haul (#9) | Old School (#10) | Double Down (#11) | The Getaway (#12) | The Meltdown (#13) | Wrecking Ball (#14) | The Deep End (#15) | Big Shot (#16) | Diper Överlöde (#17) | No Brainer (#18) | Hot Mess (#19) | Partypooper (#20)See the Wimpy Kid World in a whole new wa

The Iliad (c. 750 BCE) is one of the oldest works of literature in existence and continues to stir the imagination of contemporary readers thanks to its epic depictions of martial prowess, heroism, and tragedy.Aiming to bring the legendary story to a new audience, Samuel Butler eschewed the traditional poetical style in favor of a prose translation more akin to that used in the 18th and 19th centuries without losing any of the beauty of the original. The narrative details the fall of Troy and the many tragedies that befall both sides of the war. Heroes clash in sweeping and brutal battle as the Gods watch on in delight, Kings rise and fall by their honor-bound mandates while their men toil in the mundanity of war, and lovers die desperately trying to turn the tides of fate. The Iliad is a meditation on fate, honor, and heroism, painting a world in which the chaos of humanity's clashing vanities means something greater to not only ourselves, but the Gods above.Since our inception in 202

The Iliad (c. 750 BCE) is one of the oldest works of literature in existence and continues to stir the imagination of contemporary readers thanks to its epic depictions of martial prowess, heroism, and tragedy.Aiming to bring the legendary story to a new audience, Samuel Butler eschewed the traditional poetical style in favor of a prose translation more akin to that used in the 18th and 19th centuries without losing any of the beauty of the original. The narrative details the fall of Troy and the many tragedies that befall both sides of the war. Heroes clash in sweeping and brutal battle as the Gods watch on in delight, Kings rise and fall by their honor-bound mandates while their men toil in the mundanity of war, and lovers die desperately trying to turn the tides of fate. The Iliad is a meditation on fate, honor, and heroism, painting a world in which the chaos of humanity's clashing vanities means something greater to not only ourselves, but the Gods above.Since our inception in 202

In clear, accessible and engaging style Thought: The Basics gets to grips with the nature of human thought with just the right balance of theory and examples from philosophy, psychology and neuroscience. Ideal for anyone coming to this fascinating but deceptively difficult topic for the first time.

Shortlisted for Foyles Book of the Year 2024 Take flight on this beautifully-written, epic and soaring new adventure, perfect for fans of Abi Elphinstone, Aisling Fowler, A. F. Steadman and Pari Thompson. Astrid has lived in the rhubarb shed her whole life. The outside world is dangerous, Mama explains; she will understand when she's older, but she cannot set foot beyond the door. Astrid longs to see the world; to meet other children; to live in the farmhouse with Mama. But what she longs for most of all is to see the stars.Then one night, a stranger unlocks the shed: a stranger with wings. She has come to take Astrid to a secret city in the sky called London Overhead, far above the highest peak of the Shard. For Astrid, like her, is a Librae - and will soon grow wings of her own . . .Astrid is swept into a breathtaking and magical world of new friendships, sweeping adventures and unimaginable discoveries at the ancient, beautiful school for Librae students: Starminster. But quickly

Ancient Macedonia is often synonymous with Alexander the Great. After all, his conquests stretched the Macedonian Empire thousands of miles wide, and during his reign Macedonia was without equal. Alexander and his father, Philip II, who raised Macedonia to superpower status, still dominate our perceptions of this ancient kingdom and empire. Macedonian kings before Philip and Alexander are often portrayed as their opposites--weak and ineffectual--but this book proves that this is a mistake. While Macedonia under the Argead Kings covers the reigns of Philip, Alexander, and his immediate successors, it takes an even closer look at what life was like in Macedonia before its most famous rulers. While the literary evidence speaks of Macedonia's internal disunity during this period, as well as its dynastic upheavals, it is important to note that the authors of this literature were often Greeks, who had very different perspectives of what their enemies, the Macedonians, were like. This book su

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of neoplastic and nonneoplastic diseases of the liver, biliary tree, pancreas, and gallbladder, it incorporates the most recent clinical, pathologic, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the fourth edition of Diagnostic Pathology: Hepatobiliary and Pancreas is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.Presents clear delineations in challenging diagnoses for both nonneoplastic and neoplastic settings, illustrates novel tumor variants, uses updated terminology and society guidelines, and summarizes the role of molecular findings for diagnosisAnalyzes hundreds of diagnoses, each of which include critical diagnostic