Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

DescriptionTrailblazer cultivates critical thinkers, readers, and writers and provides the language support they need to be ready to study subject-matter content in English. Trailblazing students take meaningful action beyond the classroom by developing the ability to shape their own answers to life’s big questions, and to view these questions through multiple perspectives.A multiple literacy approach helps prepare students for meaningful real-world interaction.Authentic non-fiction, globally diverse fiction, and information presented through multi-media inputs prompt students to think critically and apply their language and skills to real-world contexts.The real-life stories of National Geographic Explorers inspire a new generation of trailblazing students to make a positive impact on their community.Assessment of English language skills and strategies helps instructors to track learning outcomes, and students to meet their learning goals, including success on international exams.Inte

DescriptionTrailblazer cultivates critical thinkers, readers, and writers and provides the language support they need to be ready to study subject-matter content in English. Trailblazing students take meaningful action beyond the classroom by developing the ability to shape their own answers to life’s big questions, and to view these questions through multiple perspectives.A multiple literacy approach helps prepare students for meaningful real-world interaction.Authentic non-fiction, globally diverse fiction, and information presented through multi-media inputs prompt students to think critically and apply their language and skills to real-world contexts.The real-life stories of National Geographic Explorers inspire a new generation of trailblazing students to make a positive impact on their community.Assessment of English language skills and strategies helps instructors to track learning outcomes, and students to meet their learning goals, including success on international exams.Inte

DescriptionTrailblazer cultivates critical thinkers, readers, and writers and provides the language support they need to be ready to study subject-matter content in English. Trailblazing students take meaningful action beyond the classroom by developing the ability to shape their own answers to life’s big questions, and to view these questions through multiple perspectives.A multiple literacy approach helps prepare students for meaningful real-world interaction.Authentic non-fiction, globally diverse fiction, and information presented through multi-media inputs prompt students to think critically and apply their language and skills to real-world contexts.The real-life stories of National Geographic Explorers inspire a new generation of trailblazing students to make a positive impact on their community.Assessment of English language skills and strategies helps instructors to track learning outcomes, and students to meet their learning goals, including success on international exams.Inte

DescriptionTrailblazer cultivates critical thinkers, readers, and writers and provides the language support they need to be ready to study subject-matter content in English. Trailblazing students take meaningful action beyond the classroom by developing the ability to shape their own answers to life’s big questions, and to view these questions through multiple perspectives.A multiple literacy approach helps prepare students for meaningful real-world interaction.Authentic non-fiction, globally diverse fiction, and information presented through multi-media inputs prompt students to think critically and apply their language and skills to real-world contexts.The real-life stories of National Geographic Explorers inspire a new generation of trailblazing students to make a positive impact on their community.Assessment of English language skills and strategies helps instructors to track learning outcomes, and students to meet their learning goals, including success on international exams.Inte

DescriptionTrailblazer cultivates critical thinkers, readers, and writers and provides the language support they need to be ready to study subject-matter content in English. Trailblazing students take meaningful action beyond the classroom by developing the ability to shape their own answers to life’s big questions, and to view these questions through multiple perspectives.A multiple literacy approach helps prepare students for meaningful real-world interaction.Authentic non-fiction, globally diverse fiction, and information presented through multi-media inputs prompt students to think critically and apply their language and skills to real-world contexts.The real-life stories of National Geographic Explorers inspire a new generation of trailblazing students to make a positive impact on their community.Assessment of English language skills and strategies helps instructors to track learning outcomes, and students to meet their learning goals, including success on international exams.Inte

DescriptionTrailblazer cultivates critical thinkers, readers, and writers and provides the language support they need to be ready to study subject-matter content in English. Trailblazing students take meaningful action beyond the classroom by developing the ability to shape their own answers to life’s big questions, and to view these questions through multiple perspectives.A multiple literacy approach helps prepare students for meaningful real-world interaction.Authentic non-fiction, globally diverse fiction, and information presented through multi-media inputs prompt students to think critically and apply their language and skills to real-world contexts.The real-life stories of National Geographic Explorers inspire a new generation of trailblazing students to make a positive impact on their community.Assessment of English language skills and strategies helps instructors to track learning outcomes, and students to meet their learning goals, including success on international exams.Inte

DescriptionTrailblazer cultivates critical thinkers, readers, and writers and provides the language support they need to be ready to study subject-matter content in English. Trailblazing students take meaningful action beyond the classroom by developing the ability to shape their own answers to life’s big questions, and to view these questions through multiple perspectives.A multiple literacy approach helps prepare students for meaningful real-world interaction.Authentic non-fiction, globally diverse fiction, and information presented through multi-media inputs prompt students to think critically and apply their language and skills to real-world contexts.The real-life stories of National Geographic Explorers inspire a new generation of trailblazing students to make a positive impact on their community.Assessment of English language skills and strategies helps instructors to track learning outcomes, and students to meet their learning goals, including success on international exams.Inte

DescriptionTrailblazer cultivates critical thinkers, readers, and writers and provides the language support they need to be ready to study subject-matter content in English. Trailblazing students take meaningful action beyond the classroom by developing the ability to shape their own answers to life’s big questions, and to view these questions through multiple perspectives.A multiple literacy approach helps prepare students for meaningful real-world interaction.Authentic non-fiction, globally diverse fiction, and information presented through multi-media inputs prompt students to think critically and apply their language and skills to real-world contexts.The real-life stories of National Geographic Explorers inspire a new generation of trailblazing students to make a positive impact on their community.Assessment of English language skills and strategies helps instructors to track learning outcomes, and students to meet their learning goals, including success on international exams.Inte

DescriptionTrailblazer cultivates critical thinkers, readers, and writers and provides the language support they need to be ready to study subject-matter content in English. Trailblazing students take meaningful action beyond the classroom by developing the ability to shape their own answers to life’s big questions, and to view these questions through multiple perspectives.A multiple literacy approach helps prepare students for meaningful real-world interaction.Authentic non-fiction, globally diverse fiction, and information presented through multi-media inputs prompt students to think critically and apply their language and skills to real-world contexts.The real-life stories of National Geographic Explorers inspire a new generation of trailblazing students to make a positive impact on their community.Assessment of English language skills and strategies helps instructors to track learning outcomes, and students to meet their learning goals, including success on international exams.Inte

DescriptionTrailblazer cultivates critical thinkers, readers, and writers and provides the language support they need to be ready to study subject-matter content in English. Trailblazing students take meaningful action beyond the classroom by developing the ability to shape their own answers to life’s big questions, and to view these questions through multiple perspectives.A multiple literacy approach helps prepare students for meaningful real-world interaction.Authentic non-fiction, globally diverse fiction, and information presented through multi-media inputs prompt students to think critically and apply their language and skills to real-world contexts.The real-life stories of National Geographic Explorers inspire a new generation of trailblazing students to make a positive impact on their community.Assessment of English language skills and strategies helps instructors to track learning outcomes, and students to meet their learning goals, including success on international exams.Inte

DescriptionTrailblazer cultivates critical thinkers, readers, and writers and provides the language support they need to be ready to study subject-matter content in English. Trailblazing students take meaningful action beyond the classroom by developing the ability to shape their own answers to life’s big questions, and to view these questions through multiple perspectives.A multiple literacy approach helps prepare students for meaningful real-world interaction.Authentic non-fiction, globally diverse fiction, and information presented through multi-media inputs prompt students to think critically and apply their language and skills to real-world contexts.The real-life stories of National Geographic Explorers inspire a new generation of trailblazing students to make a positive impact on their community.Assessment of English language skills and strategies helps instructors to track learning outcomes, and students to meet their learning goals, including success on international exams.Inte

Play zoo with Bluey and Bingo in this storybook based on the wildly successful animated series Bluey, as seen on Disney+! OOH-AH-AH! Bluey and Bingo are playing zoo! They turn their backyard into a home for all sorts of amazing creatures, including a big blue daddy gorilla. But when Ooh-Ooh escapes, will zookeeper Bluey be able to track him down?

**This new hardcover edition of the fourth book in the #1 New York Times bestselling Never After series has specially designed edges, an exclusive case design, and full-color art.**She's his diamond in the rough. He's her worst nightmare.Yasmin Karam, daughter to one of the richest men in the world, has never known strife. So, when her beloved father falls ill, she's determined to make his final days his happiest. His last wish? To see her married to a man of his choosing. Except Yasmin's heart already belongs to someone else. A servant. A street rat. A man her father would never consider worthy. Stuck between a rock and a hard place, Yasmin strikes a desperate deal with her father's right-hand man, Julian, not realizing he has his own twisted agenda.Julian Faraci has one goal: become the most powerful man in the world. He's built a future from broken bones and faded bruises, never caring who he hurt along the way. But when his mentor falls ill, he finds himself on the verge of losing

A beautifully illustrated fairy tale about kindness, transformation, and adventure.Plumelet is a captivating fairy tale for children aged 5-10, written and illustrated by the author. This enchanting story follows Plumelet, a spoiled young princess who takes her privileged life for granted, treating those around her with disdain. One day, she insults a mysterious old woman at the palace gates--unaware that she is actually a powerful witch named Gargoyle. As punishment, Gargoyle casts a spell that makes Plumelet weightless, and her servant, Cold Wind, carries the frightened princess far from home. Swept into a world of magic and adventure, Plumelet finds herself trapped in an enchanted castle--a labyrinth of salt and pepper--where she must navigate unexpected challenges and encounter both kind and mischievous magical beings. Through these trials, she begins to understand the consequences of her selfishness and learns the value of kindness and friendship. Featuring stunning, surreal illus

A picture book that celebrates doing your own thing in the face of society's expectations . . . and a sweet story about a girl, her dad, her disapproving grandma and, most importantly, cars. Sarabeth loves cars. She loves the way the engines sometimes roar like lions and other times purr like kittens. She loves seeing sports cars that are sleek and fast like cheetahs and boxy SUVs that trundle along like elephants. And most of all, she loves to help her dad out at the garage. Sarabeth's Grandmother feels differently. She thinks little girls should play with dolls and wear dresses. But when her car starts grumbling like a walrus instead of purring like a kitten, will Sarabeth's hobby save the day? A delightful story about an independent and spirited girl who has no time for the limitations that society wants to put on her, and a grandma who gets the opportunity to change her way of thinking.

This stunning book showcases the art, behind-the-scenes details, and making of the Disney and Pixar animated film Hoppers. The next in the fan-favorite, collectible Disney and Pixar Art of series, The Art of Hoppers presents the story behind the newest film from Pixar Animation Studios. It highlights the stunning artwork from the film's creation--including character designs, storyboards, color scripts, and much more--and features exclusive interviews with the creative team along with behind-the-scenes details. This book is the perfect gift for aspiring artists, animators, film buffs, and fans. (c) 2026 Disney Enterprises, Inc. and Pixar. All rights reserved. EXCLUSIVE LOOK AT ANIMATION FILMMAKING: Fans will want to delve into and explore this Pixar Animation film through production art, stories, and making-of details exclusive to this book. PART OF THE FAN-FAVORITE SERIES: The collectible Art of series is perfect for animation enthusiasts, filmmakers, students, and fans of Disney and P

A leprechaun is causing all kinds of trouble on St. Patrick's Day--but our popular Gingerbread Man is back to save the day! After a mischievous leprechaun makes a mess of the band room, the Gingerbread Man vows to catch him. He follows the leprechaun's clues all around the building finding chaos everywhere--even in the library! But then he finds the worst clue of all. It says the leprechaun's next target might be a house made of gingerbread! Luckily, the Gingerbread Man makes it to his classroom in time to set a trap for the leprechaun. He'll show that mischief maker that he messed with the wrong cookie this time. "I'm on a mission! I've got a good plan.I can catch him! I'm the Gingerbread Man!" Look for all of this hilarious Gingerbread Man's adventures: The Gingerbread Man Loose at School, The Gingerbread Man Loose on the Fire Truck, The Gingerbread Man Loose at Christmas, The Gingerbread Man Loose at the Zoo, and The Gingerbread Man and the Leprechaun Loose at School!

Melissa Cristina Márquez pens another story perfect for young readers and pet owners! Leo is on the search for the "perfect" pet and stumbles upon one in an unexpected place. But in this colorful and quirky picture book, he quickly learns that sometimes raising a pet requires a village.Leo is thrilled when he and his family enter a shelter so he can adopt a new pet, but after searching for a while, Leo doesn’t feel the connection he had hoped for and leaves feeling disappointed. On the way home, he and his family see a busy marketplace and find another shelter hidden inside: one for magical creatures! There Leo connects with an alebrije, their bond forming before they can even leave the shelter. But he quickly learns just how much responsibility comes with raising a pet. Melissa Cristina Márquez, Forbes 30 Under 30 honoree, globally renowned shark scientist, and author of Mother of Sharks and Sea of Constellations, returns celebrating Mexican culture, fantastical creatures, and communi

What happens when a princess accidentally fractures her fairy tale by fleeing to the real world? Bestselling author Alex London turns classic fairy tales on their heads in this fast-paced, funny fantasy about friendship and facing your fears. For fans of The School for Good and Evil and the Never Afters series.Princess Rana loves her friends (all fellow fairy tale escapees), loves her school (the HEA, an academy for fairy tale royalty), and loves punk rock (the best music genre). But she does not love frogs . . . especially demanding frog princes who follow her home. Rana fled her story because of one frog prince in particular, and she has no plans of ever going back to that stuffy place full of rules. But then her frog prince shows up at the academy's gate. And he's not alone. Dozens of duplicate frog princes have followed him to the real world. Worse still, a shadowy monster is in hot pursuit, one that dissolves fairy tale characters into nothing, erasing their stories. To save every

An unforgettable picture book about the power of kindness and the importance of community. As Holly takes her morning stroll in the thicket, she comes across a small bird. It was plain to see he'd been through some things. The bird is alone and trying to find shelter for the winter. And Holly knows exactly what to do to help. Illustrating the transformative role a community can play in caring for its members, The Sweater is a powerful and poignant tale of compassion and acceptance.

In the sequel to darkly inventive The Labyrinth of Souls, a girl must face a mysterious monster made of nothing but darkness and shadows that no one else can see. For fans of Tim Burton, V.E. Schwab, and stories with a dash of the strange and macabre. Ix Tatterfall is no stranger to the odd and the eerie. Her unusual lineage provides unique abilities, such as a strong Darklight power and unencumbered travel into the deadly Labyrinth of Souls. But even Ix is unprepared for the Nowhere Beast, a creature that threatens to consume everything she holds dear. When the ghosts of Candle Corps past begin to rise from the catacombs, Ix and her friends are called to partake in an ancient magical tradition called the Reckoning, meant to reinforce the seals of protection at their magical school that hold the most dangerous Nightmare creatures from the Labyrinth at bay. But the Reckoning quickly transforms into more than a test of their courage and skill; it is a race against time to save their worl

New York Times-bestselling author Aiden Thomas returns to the beloved world of The Sunbearer Trials in Celestial Monsters, a heart-stopping duology finale, in which three young semidioses travel through a dark monster-infested world, facing down chaotic Obsidian gods, in a quest to save their friends and return the sun to the sky. Teo never thought he could be a Hero. Now, he doesn't have a choice. The sun is gone, the Obsidian gods have been released from their prison, and chaos and destruction are wreaking havoc on Reino del Sol. All because Teo refused to sacrifice a fellow semidi鏀 during the Sunbearer Trials. With the world plunged into perpetual night, Teo, his crush Aurelio, and his best friend Niya must journey to the dark wilderness of Los Restos, battling vicious monsters while dealing with guilt, trauma, and a (very distracting) burgeoning romance between Teo and Aurelio. Determined to rescue the captured semidioses and retrieve the Sol Stone, the trio races against the clock

Hello and welcome to the Galactic Peacekeepers Society... Today is the beginning of your incredible journey to explore, be curious and open with others, and to help spread the mission of Peace with your teammates. Peacekeeping is hard. You will feel angry. Confused. Sad. But it is okay. We will take care of our galactic neighborhood together! The first book in a breathtaking and ridiculously FUN graphic novel trilogy about a lost human girl, teaming up with her beloved crew of Peacekeepers on missions across the galaxy, all while she tries to get back to Earth and the mom and dog she left behind!

Hello and welcome to the Galactic Peacekeepers Society...Today is the beginning of your incredible journey to explore, be curious and open with others, and to help spread the mission of Peace with your teammates. Peacekeeping is hard. You will feel angry. Confused. Sad. But it is okay.We will take care of our galactic neighborhood together!The first book in a irrepressible and breathtaking graphic novel trilogy about a lost human girl, her fellow crew of Peacekeeper aliens, and their missions all across the galaxy — all while Ami tries to get back home to Earth and the mom and dog she left behind. Ami Moon and the Galactic Peacekeepers introduces an unforgettable protagonist and a singular author-illustrator debut from Frances Lee.

The second book in a brand-new contemporary romance series from Sara Cate, theUSA Todaybestselling author of The Salacious Players’ Club.***He let him get away once…Now he has seven days to get him back.Fifteen years ago, Declan Barclay left for uni with plans of becoming an artist and escaping his family’s heavy rule. What he didn’t expect was to meet a soft and enigmatic actor in desperate need of guidance…and a friend. Declan quickly took Colin Shelby under his wing and the two were inseparable ever since.That is until the night before graduation, when lines were crossed and everything changed.Now, after years apart, Colin is back in Declan’s life, but he’s not alone. He’s made a promise to marry someone else, and Declan only has seven days to win back the love of his life. There’s just one problem: His family is counting on him to pull this wedding off at Barclay Manor.With just one week until vows are exchanged, Declan must decide: stay silent and lose Colin for good, or risk ever

From #1Der Spiegelbestselling author Ayla Dade comes the second book in an angsty, new adult sports series featuring a charming second chance romance – set against the backdrop of Aspen’s snowy mountains and winter sports.He's finally back on the ice. But can he melt her heart?Aria Moore thought that two years and two thousand miles would be long and far enough. But when she returns to Aspen to help run the family B&B while her mother is ill, her feelings for Wyatt Lopez come surging back.But he betrayed her, and she's not willing to endure that kind of heartbreak ever again. If she's honest with herself, she has to admit that she still carries a torch for the charismatic ice hockey player who once broke her heart. Aria swore never to see him again – which proves impossible when Wyatt is forced to move into the B&B.Aria begins to feel hopeful when she finally meets someone new – and she makes it clear to Wyatt that they can only spend time together as friends. But on a trip int

🐺 Forbidden romance. Werewolves. Kilts.This sizzling bestselling sensation has the internet OBSESSED. 🐺'Let me have you. Just once. Please.'As dark forces rise, Princess Aurora is caught between two powerful alphas. Princess Aurora may have survived the Wolf King, but now he wants her back. To take his throne, Aurora and Callum form a dangerous alliance with one of the most feared Wolves in the Kingdom, Blake.He’s the enemy, but Aurora’s life is bound to his. If he dies, so does she. As she fights their connection, she suspects Blake is keeping secrets.There is a bigger game at play than who sits on the Wolf Throne – one that threatens both kingdoms. With enemies closing in, Aurora may be the only one who can stop an ancient evil from rising. To survive, she must decide where she – and her heart – belong.THE ROMANTASY SENSATION DRIVING READERS WILD!‘It’s a little bit Outlander, a little bit ACOTAR, and its own thing in just the perfect way.’‘Now that’s what I call ROMANTASY.’‘Gahhhh.

What nobody tells you about parenthood, from one of the 'silent partners' behind the Parenting Hell podcast. School-run coordinator, party planner, clubs organizer, laundry sorter... and maybe even a 'real' job on top! Sound exhaustingly familiar? From assumptions surrounding who is staying home with the kids to the never-ending list of 'school' admin, being 'the default parent' rears its head in a plethora of ways. So this book is for all the defaults out there - bored out of their eyeballs or so overwhelmed they could scream expletives into the wind for a solid hour - to know their invisible labor is seen, valued and can even sometimes be rebalanced. With heartfelt and hilarious advice, Lou Beckett provides much-needed comfort and community for the one who is depended on the most (and often feels appreciated the least), and maybe - just maybe - how we can begin to muddle through a little better, together.

★ 魔法、甜點與友誼交織的奇幻冒險系列★ 結合校園生活、魔法失控與爆笑事件★ 獻給喜歡《Isadora Moon》與可愛魔法故事的讀者在一個充滿魔法的小鎮裡，生活著一位熱愛烘焙的小女巫──威奇凱克（Witchycakes）。她最大的夢想，就是做出世界上最神奇、最美味的魔法甜點。但問題是……她的魔法總是有點失控。在第一集《Sweet Magic》中，她試著用魔法做出完美甜點，卻意外引發一連串甜蜜又混亂的魔法事故；第二集《Changing Magic》裡，變身魔法讓事情越變越奇怪；到了第三集《Puddles and Potions》，神祕藥水和魔法意外再次掀起一場不可思議的冒險。在朋友的陪伴與一次次失敗的嘗試中，威奇凱克慢慢發現——真正的魔法，不只是咒語，而是勇氣、創意與友情。Witchycakes Series (Books 1–3)Witchycakes #1: Sweet MagicWitchycakes #2: Changing MagicWitchycakes #3: Puddles and PotionsWitchycakes is a delightful illustrated series about a young witch who loves baking magical treats—though her spells don’t always go according to plan.In Sweet Magic, Witchycakes tries to bake the perfect magical dessert, only to cause a series of sweet and chaotic magical mishaps. In Changing Magic, a transformation spell leads to even stranger surprises. And in Puddles and Potions, mysterious potions and magical accidents spark another unforgettable adventure.With the help of her friends, Witchycakes discovers that the most power

A man must fight for his planet against impossible odds when gamers from Earth attempt to remotely annihilate it in this epic, fast-paced novel from the New York Times bestselling author of the smash-hit Dungeon Crawler Carl. All colonist Oliver Lewis ever wanted to do is run the family ranch with his sister, maybe play a gig or two with his band, and keep his family's aging fleet of intelligent agriculture bots ticking as long as possible. As a fan of Earth television and culture, he figures it will be a good thing when the transfer gate finally opens all the way and restores instant travel and full communication between Earth and his planet, New Sonora. But there's a complication. Even though the settlers were promised they'd be left in peace, Earth's government now has other plans. The colossal Apex Corporation is hired to commence an "eviction action." But maximizing profits will always be Apex's number one priority. Why spend money printing and deploying their own AI soldiers when

A beautifully illustrated fairy tale about kindness, transformation, and adventure.Plumelet is a captivating fairy tale for children aged 5-10, written and illustrated by the author. This enchanting story follows Plumelet, a spoiled young princess who takes her privileged life for granted, treating those around her with disdain. One day, she insults a mysterious old woman at the palace gates--unaware that she is actually a powerful witch named Gargoyle. As punishment, Gargoyle casts a spell that makes Plumelet weightless, and her servant, Cold Wind, carries the frightened princess far from home. Swept into a world of magic and adventure, Plumelet finds herself trapped in an enchanted castle--a labyrinth of salt and pepper--where she must navigate unexpected challenges and encounter both kind and mischievous magical beings. Through these trials, she begins to understand the consequences of her selfishness and learns the value of kindness and friendship. Featuring stunning, surreal illus

Adventures inspired by the best-selling video games. Violet Lang calls himself the Prince of Speed and races across the Paldea region in search of the Herba Mystica that will give his Pok幦on the ultimate speed. Scarlet Koito is a Treasure Hunter in search of the Treasures of Ruin. Together they are Scarlet and Violet, and ready to take on new adventures and challenges! As Scarlet and Violet continue to level up their Pok幦on Training skills, they get closer to more battles...and to discovering the secrets of the Pok幦on Miraidon. Will the reveal be worth the cost?!