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The present volume of The Deshima Diaries consists of the journals that were kept by the chiefs of the Dutch trading post in Japan during the first two decades of the so called seclusion period (1640-1868). The employees of the Dutch East India Company - since 1640 the only Europeans in Japan - had to give up their relatively free life in the port of Hirado and were forced to move to the tiny island of Deshima in the Bay of Nagasaki. Continually surrounded by Japanese guards, spies, cooks, concubines and interpreters they sought to continue their trading activities with their Japanese hosts. Once a year the chief of the factory and two or three staff members made a court voyage to Edo to pay obeisance to the Shogun. The diaries in this volume describe in detail how the Dutch merchants grappled with the severe restrictions that were imposed on them, but their writings also shed surprising light on social and economic life in Nagasaki and beyond.Contributors are: Willem Remmelink and Wou

For the last 30 years, polyphenols were in the centre of research work worldwide. Silymarin, an extract from a medicinal plant Silybum marianum, also known as milk thistle, has a special place in this group, having been used in human medicine for the management of liver diseases since ancient times. Accumulating scientific evidence indicates that silymarin is characterised by a wide range of protective pharmacological activities and this topic has received tremendous attention in recent years. However, until now there has been no single monograph addressing major questions related to silymarin chemistry, biochemistry and practical applications.The goal of this book is to provide up to date information about silymarin chemistry, biochemistry and molecular mechanisms of protective actions of this phytochemical with a special emphasis to its vitagene- and transcription factor-modulating properties. Silymarin applications in human diseases, including hepatoprotection, neuroprotection, anti