Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Alex Cross chases a cold-blooded killer...with a conscience. Shots ring out in the early morning hours in the suburbs of Washington, D.C. When the smoke clears, a prominent police official lies dead,

Alex Cross chases a cold-blooded killer...with a conscience. Shots ring out in the early morning hours in the suburbs of Washington, D.C. When the smoke clears, a prominent police official lies dead,

JAMES PATTERSON'S NON-FICTION MASTERPIECE________________________________Kennedys were always taught to win at all costs. And they did - but the costs were unimaginable . .. Across decades and generations, the Kennedys have been a family of charismatic adventurers, raised to take risks and excel. Their name is synonymous with American royalty.Their commitment to public service is legendary. But, for all the successes, the family has been blighted by assassinations, fatal accidents, drug and alcohol abuse and sex scandals. To this day, the Kennedys occupy a unique, contradictory place in the world's imagination: at once familiar and unknowable; charmed and cursed.The Kennedy Curse is a revealing, fascinating account of America's most famous family, as told by the world's most trusted storyteller. ________________________________Also published as The House of Kennedy in the US. 'When I wrote my first novel after several non-fiction works about politics, James Patterson lovingly lambasted

After a few early glitches in their relationship, Sammy and his 'bro-bot' E are now best friends. In fact, E is such a valued member of the family that the other electronic members of the House of Rob

The President's son and daughter are abducted, and Detective Alex Cross is one of the first on the scene. But someone very high-up is using the FBI, Secret Service, and CIA to keep him off the case an

The authors of the #1 New York Times bestselling Walk in My Combat Boots salute America's most courageous military heroes. ​From the storied battlefields of American military action, here are vivid, authentic stories from the men and women who gave themselves--and even their lives--serving in overseas conflict from World War II to Korea, Vietnam, Iraq, and Afghanistan. For their extraordinary selflessness, camaraderie, and patriotism...for engaging combatants while outnumbered, under pressure, under fire...for their service and sacrifice, they merited the US military's highest awards for valor, including: Medal of Honor Distinguished Service Cross Bronze and Silver Stars In the words of Medal of Honor winner Patrick Brady: "Soldiers believe life has no meaning unless it's lived for the benefit of future generations. That's why they protect America."

All that stands between an evil villain and world domination is a pair of twelve-year-olds who just learned they're time travelers. What could go wrong? Twins Pew and Basket Church dream of escaping the miserable misfortune of their isolated orphanage. Or, even better, the return of their unknown parents. But even in their wildest dreams, they never imagined the truth: The twins can travel through time. Armed only with perplexing clues to their past and a time travel talisman that is key to their future, Pew and Basket embark on an epic quest. It takes them into George Washington's war tent and on a hunt for the Liberty Bell, from the battlefields of the American Revolution to a pirate republic in the Caribbean and beyond, all in a race to uncover the secrets of their family--and outsmart time's greatest villain. History, mystery, humor, and adventure collide in this delightfully clever romp that heralds the arrival of James Patterson's newest blockbuster series.

The #1 bestselling kid detective is back! Mysteries, crime-solving, homeroom—all in a day's work for Ali Cross. Ali Cross has always looked up to his father, the famous detective Alex Cross. And after helping to solve two big cases, Ali knows he has what it takes to follow in his father's footsteps. Eager to keep solving crimes, Ali and his friends hack into police calls and go to crime scenes to watch the detectives at work—and try to crack the cases themselves. But when Ali witnesses something horrible, he has to grapple with tough questions about what it means to be a detective, and a detective's son. Will Ali find a way to follow in his father’s footsteps . . . or will he be the one in danger’s path?

Dodge missiles, map undersea caves, outrun secret agents, and uncover the ultimate treasure? That's a day in the life of the Kidds! The Kidd family is on an exciting new mission: use the augmented reality gear their parents created to uncover long-lost treasure. But then their ship, The Lost, explodes in a ball of fire! Now Bick, Beck, Tommy, and Storm are stranded on a raft in the Mediterranean Sea, and their parents have been kidnapped by maniacal treasure hunters. It's up to the Kidd siblings to follow clues around the globe to uncover an ancient treasure and save their parents...before they lose everything!

Junior, the first dog author to top the New York Times Bestseller list, leads the canine heist of the century--to fetch the ultimate treasure...DINOSAUR BONES! We're in luck, my person-pal, because we are going to see DINO-ROARS! Yes, we! Including me, Junior, everyone's favorite PUP. Not even the pesky "no dogs in the museum" rule can keep me away from this fossil-tastic FEAST-A-SAURUS. So join me to discover: How I came snout-to-face with a TERRIER-SAURUS REX in the flesh (well, the BONE)!The dustiest, moldiest, most PAW-fect sniff-a-licious scents I've ever wrapped my nose around. Why my pack of pooch pals and I planned a BARK-tastic break-in. It's going to be a HOWLING good time, so long as my friends and I don't get caught. Otherwise this FUR-RAISING adventure might end with us in the DOG HOUSE!

Hawk, the daughter of Maximum Ride, teams with her mother up to help save their beloved but dangerous city in this action-packed thriller.For Hawk, being a hero weighs heavily on her wings. In the City of the Dead, life happens in the shadows. That's why a war is brewing against an enemy no one can see. Hawk and Maximum Ride never back down from a conflict, or from each other, and they argue more than they agree.But as the dead begin to outnumber the living, a mother's experience and a daughter's instinct can make one powerful arsenal.

How can you prove your innocence when you can't remember the crime? Being a cop runs in Billy Harney's family. The son of Chicago's Chief of Detectives whose twin sister, Patti, also followed in their

How can you prove your innocence when you can't remember the crime?Being a cop runs in Billy Harney's family. The son of Chicago's Chief of Detectives whose twin sister, Patty, also followed in their

In Boston, a young woman finds herself pregnant--even though she is still a virgin.In Ireland, another young woman discovers she is in the same impossible condition.And in cities all around the world,

In the seventh book in the bestselling series, evil scientists are still trying to convince Max that she needs to save the world, this time by providing the genetic link in speeding up the pace of evo

Alex Cross was a rising star in the Washington, DC, Police Department when an unknown shooter gunned down his wife, Maria, in front of him. Alex's need for vengeance was placed on hold as he faced ano

Alex Cross was a rising star in the Washington, DC, Police Department when an unknown shooter gunned down his wife, Maria, in front of him. Alex's need for vengeance was placed on hold as he faced ano

FBI Agent Alex Cross is on vacation with his family in Disneyland when he gets a call from the Director. A well-known actress was shot outside her home in Beverly Hills. Shortly afterward, an editor f

FBI agent Alex Cross is on vacation with his family in Disneyland when he gets a call from the director. A top actress has been shot outside her home in Beverly Hills. Shortly afterward, an editor fo

Have you ever gotten a letter that changed your life completely? Sam's Letters to Jennifer is a novel about that kind of drama. In it, a woman is summoned back to the town where she grew up. And in th

Four women-four friends-share a determination to stop a killer who has been stalking newlyweds in San Francisco. Each one holds a piece of the puzzle: Lindsay Boxer is a homicide inspector in the San

In Boston, a young woman finds herself pregnant--even though she is still a virgin.In Ireland, another young woman discovers she is in the same impossible condition.And in cities all around the world,

Detective Alex Cross is in love. But his happiness is threatened by a series of chilling murders in Washington, D.C., murders with a pattern so twisted, it leaves investigators reeling. Cross's ingeni

Jane "Effing" Smith has never lost a case. But the body count leading up to her last trial makes it clear: someone will do anything to keep her from winning again. Attorney Jane Smith's top client is a Hamptons real estate celebrity standing trial for triple homicide. When her client's many enemies put Jane at the top of their kill list, mounting a legal defense turns into self-defense. Knowing every day in court could be her last, she's armed and ready: with brilliant arguments, hard evidence--and two Glock 26s. Until she hears the words "not guilty," Jane Smith will Never Say Die.

Move over, John Grisham! Biloxi's best criminal defense attorney has never lost a case. Then his wife is murdered, and he becomes the nation's #1 suspect. Stafford Lee Penney is a small-town lawyer with a big-time reputation for winning every case he tries. In his sharp suits and polished Oxford shoes, Penney is Biloxi, Mississippi's #1 Lawyer and top local celebrity. Just as Penney notches his latest courtroom victory, his wife is scandalously killed. He spirals into a legal and personal losing streak, damaging his reputation and ruining his career. That's when Penney makes a bold decision. He stops trading on his power-lawyer identity and creates a new one: lawyer lifeguard. Moonlighting at the beach, showing up to court in flip-flops, mentoring a law student, the new Penney is at first unrecognizable. It's said that a lawyer who represents himself has a fool for a client. But when Penney's accused of murder, the #1 Lawyer will find a way to triumph.

A superstitious killer targeting young women in every borough of New York City has Detective Michael Bennett facing his most terrifying case since Step on a Crack. A killer is obsessed... with Detective Michael Bennett's oldest daughter. Michael Bennett is obsessed... with keeping his family safe. New York City is obsessed... with cracking the killer's code. You will be obsessed... with this startling psychological thriller. Obsessed.

They risk their lives every day to protect and serve our homes, families and communities. Here are their most dramatic true stories, in their own unforgettable words.PROTECT These men and women are our eyes. Our ears. Our protectors.Those who wear a badge, doing their best to help people. SERVE These cops serve their communities. They serve their country. They're in the business of saving lives--even at the risk of their own. DEFEND These patrol officers and K9 handlers, sheriffs and detectives, reveal what it's really like to wear the uniform, to carry the weight of the responsibility they've been given. This is a calling. This is the job.

Nothing could tear Detective Michael Bennett away from his new bride―except the murder of the woman who was his partner and best friend.NYPD master homicide investigator Michael Bennett and top FBI abduction specialist Emily Parker have a history. Working case after case, each can predict the other’s next move. So when she fails to show at FBI headquarters in Washington, DC, Bennett risks venturing far outside his jurisdiction. The investigation her undertakes is the most brilliant detective work of his career…and the most intensely personal. A portrait begins to emerge of a woman as adept at keeping secrets as forging powerful connections. A woman whose enemies had both the means and the motives to silence the real Emily Parker―and her protectors.

How did a kid whose dad lived in the poorhouse become the most successful storyteller in the world? ​ I once told a writer at Vanity Fair that I'd like my obituary to begin like this, "He was slowing down at a hundred and one and had only finished four novels that year." I got infamous writing mysteries, so here's the big mystery plot for this book. How did a shy, introspective kid from upstate New York, without a lot of guidance or role models, go on to become the youngest ever CEO of the advertising agency J. Walter Thompson, North America? How did this same person become the bestselling writer in the world? One thing that I've learned and taken to heart is to tell stories. When I write, I pretend there's one person sitting across from me, and I don't want them to get up until I'm finished with the story. Right now, that person is you.

Art galleries and casinos, mansions and brothels, billionaires and thieves―only James Patterson could create a triple-cross this decadent and suspenseful.Imagine everyone’s surprise when Carter von Oehson, a sophomore in Dr. Dylan Reinhart’s Abnormal Psychology class, posts on Instagram that he plans to kill himself. 24 hours later and still no one has seen him.Release the hounds. A massive search ensues. But when Carter’s sailboat rolls in with the tide without him or anyone else on it, the worst seems to be confirmed. He really did it . . . Or did he? The one person convinced he’s still alive is his father, Mathias von Oehson, founder and CEO of the world’s largest hedge fund. But what Mathias knows and how he knows it would ultimately reveal a secret so damaging that it would be as if he were committing suicide himself. There’s no way he can go to the police. But there’s still someone he can turn to.Dylan now finds himself wrapped up in multi-million-dollar secrets and danger and it

Rafe feels like a caged lion at his summer job at the zoo―until a real lion desperately needs his help.Rafe Khatchadorian is days away from sweet, sweet summer freedom until bad grades threaten to land him in . . . SUMMER SCHOOL.It’s impossible to fail out of a summer job, right? Wrong. He strikes out at the zoo then grosses out at a billionaire's country club:Digging a pit for the annual clambakeScrubbing chewed bubblegum, sooty fireplaces, and . . . toiletsPolishing the chrome on his boss's ATVRafe is destined for the Failed Jobs Hall of Fame until an encounter with an endangered lion puts his wildlife knowledge to the test . . . and it's more than his grade on the line this time.

In this funny and paw-some story, lifelong rivals Molly and Oscar are forced to team up and brave the great outdoors and help their families before it’s too late.Wilderness adventurers and expert trackers Molly the katt and Oscar the dogg go camping with their families: parents, siblings, cousins, aunts, and uncles. One big reunion! It would be fun if there weren't so many rules to follow at the campsite. ATTENTION KATTS AND DOGGS: No crossing the border, or you'll be asked to leave the Eastern Wilderness Reserve. If you're still alive.Molly and Oscar must outsmart the rule-makers when they discover that their katt and dogg cousins have run away together―for reasons only Molly and Oscar will understand. Now the clever pair must find and warn their cousins before all four of them are in need of a serious rescue mission.

John Lennon achieved with the Beatles a level of superstardom that defied classification. "We were the best bloody band there was," he said. "There was nobody to touch us." In the summer of 1980, Lenn

A double homicide in the nation's capital opens the psychological case files -- Detective Alex Cross. Kay Willingham led a life as glamorous as it was public -- she was a gorgeous Georgetown socialite

Life as a dog is one adventure to the next. Lovable mischief-making canine Junior gets into a lot of trouble, from wacky escapades in obedience school to stealing the family dinner---read about all th

There's a mystery mischief-maker on the loose in Hills Village! Can Junior solve the mystery before disaster strikes? Junior is loving his life with the Khatchadorian family. But his idyllic life soon

As seen on ID, these two true-crime thrillers follow a neighbors' quarrel that turns violent and cyber-bullying that explodes in a double murder.Murder Thy Neighbor: Ann Hoover is a nice woman but she

A story for a new generation of Maximum Ride fans! 17-year-old Hawk is growing up hard and fast in post-apocalyptic New York City . . . until a perilous destiny forces her to take flight.Where is Maxi

With their parents in trouble once again, the Kidds must traverse the Australian Outback, recover a pair of stolen gems, and defeat treasure-hunting pirates to save them!The Kidd family is on their wa

Three missing women. Two impossible cases. One determined detective.When three teachers disappear without a trace, Sergeant Lindsay Boxer takes the lead in the investigation. But with no clues and no