Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Soon to be a major motion picture starring Matthew McConaughey and Idris ElbaThe second volume in Stephen King’s #1 bestselling Dark Tower Series, The Drawing of the Three is an “epic in the making” (

A thrilling collection of twenty stories - some brand new, some published in magazines, all entirely brilliant and assembled in one book for the first time - with a wonderful bonus: in addition to his

Set in a small-town North Carolina amusement park in 1973, Joyland tells the story of the summer in which college student Devin Jones comes to work in a fairground and confronts the legacy of a viciou

"In a mega-stakes, high-suspense race against time, three of the most unlikely and winning heroes Stephen King has ever created try to stop a lone killer from blowing up thousands. In the frigid pre-d

"In a mega-stakes, high-suspense race against time, three of the most unlikely and winning heroes Stephen King has ever created try to stop a lone killer from blowing up thousands. In the frigid pre-d

A STUNNING NEW NOVEL FROM ONE OF THE BEST-SELLING AUTHORS OF ALL TIME - NOW OUT IN MASS MARKET PAPERBACK!The #1 NEW YORK TIMES BESTSELLER!Set in a small-town North Carolina amusement park in 1973, Joy

In a small-town North Carolina amusement park in 1973, college student Devin Jones comes to work as a carny and confronts the legacy of a vicious murder, the fate of a dying child and the ways both wi

The Dark Tower is soon to be a major motion picture starring Matthew McConaughey and Idris Elba, due in cinemas August 18, 2017. 'The man in black fled across the desert, and the gunslinger followed.'

Ben Mears has returned?to Jerusalem's Lot in the hopes that living in an?old mansion, long the subject of town lore, will?help him cast out his own devils and provide inspiration for his new book. But

ON NOVEMBER 22, 1963, THREE SHOTS RANG OUT IN DALLAS, PRESIDENT KENNEDY DIED, AND THE WORLD CHANGED. WHAT IF YOU COULD CHANGE IT BACK? In this brilliantly conceived tour de force, Stephen King—who has

Come close, children, and see the living crocodile. A vintage '54 Buick Roadmaster. At least, that's what it looks like ...There is a secret hidden in Shed B in the state police barracks in Statler, P

In Derry, Maine, four young boys once stood together and did a brave thing. Something that changed them in ways they hardly understand.A quarter of a century later, the boys are men who have gone thei

For the first time in one volume, each with a fascinating introduction, come the stories of Rita Hayworth and Shawshank Redemption, Hearts in Atlantis (Low Men in Yellow Coats), 1408, The Mangler and

The state police of Troop D in rural Pennsylvania have kept a secret in Shed B out back of the barracks ever since 1979, when Troopers Ennis Rafferty and Curtis Wilcox answered a call from a gas stat

First published in 1977, The Shining quickly became a benchmark in the literary career of Stephen King. This tale of a troubled man hired to care for a remote mountain resort over the winter, his loy

"Sometimes dead is better...." When the Creeds move into a beautiful old house in rural Maine, it all seems too good to be true: physician father, beautiful wife, charming little daughter, adorable in

After Flagg, the evil court magician, sees a mouse chance upon a grain of dragon sand behind Prince Peter's shelves and die--as did the king--in fire and smoke, he plots to imprison Peter in the Needl

A monumentally devastating plague leaves only a few survivors who, in a desert world, experience dreams of good and evil in confrontation and, through their choices, move toward an actual confrontatio

This is the way the world ends: with a nanosecond of computer error in a Defense Department laboratory and a million casual contacts that form the links in a chain letter of death.And here is the blea

NOW A MAJOR MOTION PICTUREThe brilliant and chilling first novel Stephen King ever wrote tells the tale of the contestants of a diabolically cruel competition where 100 boys start the “long walk” and there is only one winner—the one that survives.In a dystopian near-future, America has fallen on hard times. Sixteen-year-old Ray Garraty is about to compete in the annual grueling match of stamina and wits known as the Long Walk. One hundred boys must keep a steady pace of four miles per hour day and night, without ever stopping. The winner gets “The Prize”—anything he wants for the rest of his life. But the rules of the Long Walk are harsh and the stakes could not be higher. There is no finish line—the winner is the last man standing. Contestants cannot receive any outside aid whatsoever. Slow down under the speed limit and you’re given a warning. Three warnings and you’re out of the game—forever.Written by King when he was a college student and published in 1979 under the pseudonym Rich

Master storyteller Stephen King presents the “powerful” (Time) #1 New York Times bestselling classic thriller about a housekeeper with a long-hidden secret from her past―one that tests her own will to survive.When Vera Donovan, one of the wealthiest and most ill-natured residents of Maine’s Little Tall Island, dies suddenly in her home, suspicion is immediately cast on her housekeeper and caretaker, Dolores Claiborne. Dolores herself is no stranger to such mistrust, thanks to the local chatter and mysterious circumstances surrounding her abusive husband’s death twenty-nine years earlier.But if this is truly to be the day of Dolores Claiborne’s reckoning, she has a few things of her own that she’d like to get off her chest...and begins to confess a spirited, intimate, and harrowing tale of the darkest secrets hidden within her hardscrabble existence, revealing above all one woman’s unwavering determination to weather the storm of her life with grace and protect the one she loves, no mat

Legendary storyteller Stephen King goes deep into the well of his imagination in this spellbinding novel about a seventeen-year-old boy who inherits the keys to a parallel world where good and evil are at war, and the stakes could not be higher - for their world or ours. Charlie Reade looks like a regular high school kid, great at baseball and football, a decent student. But he carries a heavy load.His mom was killed in a hit-and-run accident when he was ten, and grief drove his dad to drink. Charlie learned how to take care of himself - and his dad. Then, when Charlie is seventeen, he meets Howard Bowditch, a recluse with a big dog in a big house at the top of a big hill.In the backyard is a locked shed from which strange sounds emerge, as if some creature is trying to escape. When Mr. Bowditch dies, he leaves Charlie the house, a massive amount of gold, a cassette tape telling a story that is impossible to believe, and a responsibility far too massive for a boy to shoulder.Because wi

驚悚點子貌似永遠不見枯竭的恐怖大師帶來又一場盛大的夏日驚駭饗宴。背負家計重擔的少年遇見了名叫雷達的狗與牠年邁的主人，從老人臨終前的手中接過的那捲錄音帶裡，有著某人守了一輩子的秘密，通往另一個世界的秘密…Legendary storyteller Stephen King goes deep into the well of his imagination in this spellbinding novel about a seventeen-year-old boy who inherits the keys to a parallel world where good and evil are at war, and the stakes could not be higher—for their world or ours.Charlie Reade looks like a regular high school kid, great at baseball and football, a decent student. But he carries a heavy load. His mom was killed in a hit-and-run accident when he was ten, and grief drove his dad to drink. Charlie learned how to take care of himself—and his dad. Then, when Charlie is 17, he meets a dog named Radar and his aging master, Howard Bowditch, a recluse in a big house at the top of a big hill, with a locked shed in the backyard. Sometimes strange sounds emerge from it. Charlie starts doing jobs for Mr. Bowditch and loses his heart to Radar. Then, when Bowditch dies, he leaves Charlie a ca

Billy Summers is a man in a room with a gun. He’s a killer for hire and the best in the business. But he’ll do the job only if the target is a truly bad guy. And now Billy wants out. But first there is one last hit. Billy is among the best snipers in the world, a decorated Iraq war vet, a Houdini when it comes to vanishing after the job is done. So what could possibly go wrong?How about everything.This spectacular can’t-put-it-down novel is part war story, part love letter to small town America and the people who live there, and it features one of the most compelling and surprising duos in King fiction, who set out to avenge the crimes of an extraordinarily evil man. It’s about love, luck, fate, and a complex hero with one last shot at redemption.You won’t put this story down, and you won’t forget Billy.Stephen King is the author of more than sixty books, all of them worldwide bestsellers. His recent work includes Fairy Tale, Billy Summers, If It Bleeds, The Institute, Elevation, The O

';It is just not possible to stop turning the pages' (The Washington Post) of this bestselling classic talean epic fantasy as only #1 New York Times bestselling author Stephen King could envision it.Once, in a kingdom called Delain, there was a king with two sons Thus begins one of the most unique tales that master storyteller Stephen King has ever writtena sprawling fantasy of dark magic and the struggle for absolute power that utterly transforms the destinies of two brothers born into royalty. Through this enthralling masterpiece of mythical adventure, intrigue, and terror, you will thrill to this unforgettable narrative filled with relentless, wicked enchantment, and the most terrible of secrets

Master storyteller Stephen King presents the classic #1 New York Times bestseller--soon to be a major motion picture! Andy McGee and Vicky Tomlinson were once college students looking to make some extra cash, volunteering as test subjects for an experiment orchestrated by the clandestine government organization known as The Shop. But the outcome unlocked exceptional latent psychic talents for the two of them--manifesting in even more terrifying ways when they fell in love and had a child. Their daughter, Charlie, has been gifted with the most extraordinary and uncontrollable power ever seen--pyrokinesis, the ability to create fire with her mind. Now the merciless agents of The Shop are in hot pursuit to apprehend this unexpected genetic anomaly for their own diabolical ends by any means necessary...including violent actions that may well ignite the entire world around them as Charlie retaliates with a fury of her own...

No. 1 bestselling author Stephen King's unforgettable novella - first included in his 1990, award-winning collection Four Past Midnight and made into a highly acclaimed miniseries - about a terrifying

The No. 1 bestselling author Stephen King's novella The Sun Dog, published in his award-winning 1990 story collection Four Past Midnight, is now available as a standalone publication. It's mine - that

The chilling novella featured in Stephen King's bestselling collection Full Dark, No Stars, 1922 - about a man who succumbs to the violence within - is now available as a stand-alone publication. I be

The No. 1 bestselling author Stephen King's memorable story Apt Pupil - published in his 1982 story collection Different Seasons and made into a movie starring Ian McKellan and Brad Renfro - is now av

An epic war between good and evil, a gory, glorious story that will thrill the millions of hyper-devoted readers of The Shining and wildly satisfy anyone new to the territory of this icon in the King

One of the true classics of horror fiction, THE SHINING is regarded as one of Stephen King's masterpieces.Danny is only five years old, but in the words of old Mr Hallorann he is a 'shiner', aglow wit

Hodder are boosting Stephen King's backlist with new covers, new author branding and a marketing campaign that directs readers to the right King title for them.'Turn off the television - in fact, why

The tie-in edition of the nine-part CBS All Access series starring Whoopi Goldberg, Alexander Skarsgård, and James Marsden, premiering December 17, 2020.A patient escapes from a biological testing fac

The tie-in edition of the nine-part CBS All Access series starring Whoopi Goldberg, Alexander Skarsgård, and James Marsden, premiering December 17, 2020.A patient escapes from a biological testing fa

From #1 New York Times bestselling author Stephen King, the most riveting and unforgettable story of kids confronting evil since It. “This is King at his best” (The St. Louis Post-Dispatch).In the mid

Now an HBO limited series starring Ben Mendelsohn!​Evil has many faces…maybe even yours in this #1 New York Times bestseller from master storyteller Stephen King.An eleven-year-old boy’s violated corp

Enter once more the world of Roland Deschain―and the world of the Dark Tower…presented in this stunning fourth graphic novel of The Drawing of the Three story arc that will unlock the doorways to terr

The first standalone novel in Stephen King's Bill Hodges trilogy (Mr Mercedes, Finders Keepers, End of Watch) - and the basis of Mr Mercedes, an AT&T Audience Original Series starring Brendon Glee

The second standalone novel in Stephen King's Bill Hodges trilogy (Mr Mercedes, Finders Keepers, End of Watch) - and the basis of the third season of Mr Mercedes, an AT&T Audience Original Series (10