Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

A fresh approach to the economics of climate change that bridges integratedassessment modeling and game theoretic modeling.Strategic Bargaining and Cooperation in GreenhouseGas Mitigations: An Integra

The latest research in the development of technologies that will allow humans to communicate, using brain signals only, with computers, wheelchairs, prostheses, and other devices. Interest in develo

This work provides an analysis of the ways that new media are experienced and studied as the subjects of history, using the examples of early recorded sound and digital networks. In "Always Already Ne

Drawing on nationally representative telephone surveys conducted from 1995 to 2000, James Katz and Ronald Rice offer a rich and nuanced picture of Internet use in America. Using quantitative data, as

Since 1990 there has been a renaissance of theoretical and empirical work on thespatial aspects of the economy--that is, where economic activity occurs and why. Using new tools--inparticular, modeling

These original essays summarize a decade of fruitful research and curriculum development using the LISP-derived language Logo. They discuss a range of issues in the areas of curriculum, learning, and

These original essays summarize a decade of fruitful research and curriculum development using the LISP-derived language Logo. They discuss a range of issues in the areas of curriculum, learning, and

A cognitive ethnography of how bioengineering scientists create innovative modeling methods.In this first full-scale, long-term cognitive ethnography by a philosopher of science, Nancy J. Nersessian offers an account of how scientists at the interdisciplinary frontiers of bioengineering create novel problem-solving methods. Bioengineering scientists model complex dynamical biological systems using concepts, methods, materials, and other resources drawn primarily from engineering. They aim to understand these systems sufficiently to control or intervene in them. What Nersessian examines here is how cutting-edge bioengineering scientists integrate the cognitive, social, material, and cultural dimensions of practice. Her findings and conclusions have broad implications for researchers in philosophy, science studies, cognitive science, and interdisciplinary studies, as well as scientists, educators, policy makers, and funding agencies. In studying the epistemic practices of scientists, Ner

Coding for a purpose: helping young people combine journalism, data, design, and code to make media that makes a difference.Educators are urged to teach “code for all”―to make a specialized field accessible for students usually excluded from it. In Code for What? Clifford Lee and Elisabeth Soep instead ask the question, “code for what?” What if coding were a justice-driven medium for storytelling rather than a narrow technical skill? What if “democratizing” computer science went beyond the usual one-off workshop and empowered youth to create digital products for social impact? Lee and Soep answer these questions with stories of a diverse group of young people in Oakland, California, who combine journalism, data, design, and code to create media that make a difference. These teenage and young adult producers created interactive projects that explored gendered and racialized dress code policies in schools; designed tools for LBGTQ+ youth experiencing discrimination; investigated facial r

An illustrated guide to exploring the Universe in three dimensions.Astronomers have made remarkable discoveries about our Universe, despite their reliance on the flat projection, or 2D view, the sky has offered them. But now, drawing on the vast stores of data available from telescopes and observatories on the ground and in space, astronomers are using 3D technology to go beyond a flattened view of the cosmos. In Stars in Your Hand, Kimberly Arcand and Megan Watzke offer an illustrated guide to exploring the Universe in three dimensions, with easy-to-follow instructions for creating models of stars and constellations using a 3D printer and 3D computer imaging. Stars in Your Hand and 3D technology make learning about space an adventure. Intrigued by the stunning images from high-powered telescopes? Using this book, you can fly virtually through a 3D spacescape and hold models of cosmic objects in your hand. Arcand and Watzke outline advances in 3D technology, describe some amazing recen

A textbook that uses a hands-on approach to teach principles of programming languages, with Java as the implementation language.This introductory textbook teaches the principles of programming languages by using an experiential learning style, in which students learn about language features by realizing those features in a pedagogical compiler. Students use Java―the most commonly used programming language in the first two years of the computer science curriculum―as the implementation language throughout. The book also discusses a range of emerging topics in programming languages missing from existing textbooks, including concurrency, Big Data, and event-driven programming. The goal is to prepare students to design, implement, analyze, and understand both domain-specific and general-purpose programming languages. The book first develops basic concepts in languages, including means of computation using primitive values, means of combination such as variable definition and functions, an

Experiments in architectural education in the post–World War II era that challenged and transformed architectural discourse and practice. In the decades after World War II, new forms of learning transformed architectural education. These radical experiments sought to upend disciplinary foundations and conventional assumptions about the nature of architecture as much as they challenged modernist and colonial norms, decentered building, imagined new roles for the architect, and envisioned participatory forms of practice. Although many of the experimental programs were subsequently abandoned, terminated, or assimilated, they nevertheless helped shape and in some sense define architectural discourse and practice. This book explores and documents these radical pedagogies and efforts to defy architecture’s status quo. The experiments include the adaptation of Bauhaus pedagogy as a means of “unlearning” under the conditions of decolonization in Africa; a movement to design for “every body,

Best practices for addressing the bias and inequality that may result from the automated collection, analysis, and distribution of large datasets.Human-centered data science is a new interdisciplinary field that draws from human-computer interaction, social science, statistics, and computational techniques. This book, written by founders of the field, introduces best practices for addressing the bias and inequality that may result from the automated collection, analysis, and distribution of very large datasets. It offers a brief and accessible overview of many common statistical and algorithmic data science techniques, explains human-centered approaches to data science problems, and presents practical guidelines and real-world case studies to help readers apply these methods. The authors explain how data scientists’ choices are involved at every stage of the data science workflow―and show how a human-centered approach can enhance each one, by making the process more transparent, aski

The emergence of ketamine--previously known as a combat anesthetic and club drug--as a treatment for depression.Ketamine, approved in 2019 by the Food and Drug Administration for the treatment of depr

How to use data as a tool for empowerment rather than oppression. Big data can be used for good--from tracking disease to exposing human rights violations--and for bad--implementing surveillance and c

How to analyze data settings rather than data sets, acknowledging the meaning-making power of the local.In our data-driven society, it is too easy to assume the transparency of data. Instead, Yanni Lo

A concise introduction to the emerging field of data science, explaining its evolution, relation to machine learning, current uses, data infrastructure issues, and ethical challenges.The goal of data

A hands-on approach to tasks and techniques in data stream mining and real-time analytics, with examples in MOA, a popular freely available open-source software framework.Today many information source

In September 2015, the United Nations General Assembly adopted the Sustainable Development Goals as part of the 2030 Agenda for Sustainable Development. The Sustainable Development Goals built on and

As neural data becomes increasingly complex, neuroscientists now require skills in computer programming, statistics, and data analysis. This book teaches practical neural

Big data is ubiquitous but heterogeneous. Big data can be used to tally clicks and traffic on web pages, find patterns in stock trades, track consumer preferences, identi

Big data is ubiquitous but heterogeneous. Big data can be used to tally clicks and traffic on web pages, find patterns in stock trades, track consumer preferences, identi

Cities and regions grow (or occasionally decline), and continuously transform themselves as they do so. This book describes the theory and practice of modeling the spatial dynamics of urban growth and

Sparse modeling is a rapidly developing area at the intersection of statisticallearning and signal processing, motivated by the age-old statistical problem of selecting a smallnumber of predictive var

Downloadable Excel worksheets and solutions to end-of-chapter exercises accompanyFinancial Modeling, Fourth Edition, by Simon Benninga. Access codes are required to download thesupplemental material.

In the age of Big Data, the tools of information visualization offer us a macroscopeto help us make sense of the avalanche of data available on every subject. This book offers a gentleintroduction to

In Monitoring Movements in Development Aid, Casper Jensen and BritWinthereik consider the processes, social practices, and infrastructures that are emerging tomonitor development aid, discussing both

After experiencing spectacular economic growth and industrial development for much ofthe postwar era, Japan plunged abruptly into recession in the early 1990s and since then hassuffered a prolonged pe

Using bioinformatics methods to generate a systems-level view of the immune system; description of the main biological concepts and the new data-driven algorithms.Despite the fact that advanced bioinf

Large transaction-processing applications, such as banking, flight reservations, telecommunications, and networking, demand increasingly high throughput and fast response times. Coupling multiple syst

Data-Parallel Programming demonstrates that architecture-independent parallel programming is possible by describing in detail how programs written in a high-level SIMD programming language may be comp

The authors, two of the most prominent game theorists of this generation, havedevoted a number of years to the development of the theory presented here, and to its economicapplications. They propose r

Volume I, Wealth and Poverty, addresses domestic or internal development problems. Essays in Development Economics collects many of Jagdish Bhagwati's writings that have established him as a major p

The assembly of an archive of longitudinal data on the world's nation-states was undertaken by the Center for Comparative Political Research in 1968, with computer-facilitated procedures for the stora

A new model of urban governance, mapping the route to a more equitable management of a city’s infrastructure and services.The majority of the world’s inhabitants live in cities, but even with the vast wealth and resources these cities generate, their most vulnerable populations live without adequate or affordable housing, safe water, healthy food, and other essentials. And yet, cities also often harbor the solutions to the inequalities they create, as this book makes clear. With examples drawn from cities worldwide, Co-Cities outlines practices, laws, and policies that are presently fostering innovation in the provision of urban services, spurring collaborative economies as a driver of local sustainable development, and promoting inclusive and equitable regeneration of blighted urban areas.Identifying core elements of these diverse efforts, Sheila R. Foster and Christian Iaione develop a framework for understanding how certain initiatives position local communities as key actors in the

An approachable introduction to elementary sheaf theory and its applications beyond pure math.Sheaves are mathematical constructions concerned with passages from local properties to global ones. They have played a fundamental role in the development of many areas of modern mathematics, yet the broad conceptual power of sheaf theory and its wide applicability to areas beyond pure math have only recently begun to be appreciated. Taking an applied category theory perspective, Sheaf Theory through Examples provides an approachable introduction to elementary sheaf theory and examines applications including n-colorings of graphs, satellite data, chess problems, Bayesian networks, self-similar groups, musical performance, complexes, and much more. With an emphasis on developing the theory via a wealth of well-motivated and vividly illustrated examples, Sheaf Theory through Examples supplements the formal development of concepts with philosophical reflections on topology, category theory, and

How the FDA was shaped by public health crises and patient advocacy, told against a background of the contentious hearings on the breast cancer drug Avastin.Food and Drug Administration approval for COVID-19 vaccines and the controversial Alzheimer’s drug Aduhelm made headlines, but few of us know much about how the agency does its work. Why is the FDA the ultimate US authority on a drug’s safety and efficacy? In Drugs and the FDA, Mikkael Sekeres―a leading oncologist and former chair of the FDA’s cancer drug advisory committee―tells the story of how the FDA became the most trusted regulatory agency in the world. It took a series of tragedies and health crises, as well as patient advocacy, for the government to take responsibility for ensuring the efficacy and safety of drugs and medical devices. Before the FDA existed, drug makers could hawk any potion, claim treatment of any ailment, and make any promise on a label. But then, throughout the twentieth century, the government was forc

Through practices of collaborative imagination and making, or "doing design otherwise,” design experiments can contribute to keeping local democracies vibrant.In this counterpoint to the grand narratives of design punditry, Carl DiSalvo presents what he calls “doing design otherwise.” Arguing that democracy requires constant renewal and care, he shows how designers can supply novel contributions to local democracy by drawing together theory and practice, making and reflection. The relentless pursuit of innovation, uncritical embrace of the new and novel, and treatment of all things as design problems, says DiSalvo, can lead to cultural imperialism. In Design as Democratic Inquiry, he recounts a series of projects that exemplify engaged design in practice. These experiments in practice-based research are grounded in collaborations with communities and institutions. The projects DiSalvo describes took place from 2014 to 2019 in Atlanta. Rather than presume that government, industry―or

An examination of the contradictions within a form of expression that is both public and private, specific and abstract, conventional and countercultural. Snapshots capture everyday occasions. Taken by amateur photographers with simple point-and-shoot cameras, snapshots often commemorate something that is private and personal; yet they also reflect widely held cultural conventions. The poses may be formulaic, but a photograph of loved ones can evoke a deep affective response. In Snapshot Photography, Catherine Zuromskis examines the development of a form of visual expression that is both public and private. Scholars of art and culture tend to discount snapshot photography; it is too ubiquitous, too unremarkable, too personal. Zuromskis argues for its significance. Snapshot photographers, she contends, are not so much creating spontaneous records of their lives as they are participating in a prescriptive cultural ritual. A snapshot is not only a record of interpersonal intimacy but also

Theoretical and empirical analyses of whether open innovations in international development instrumentally advantages poor and marginalized populations.Over the last ten years, "open" innovations--the