Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

★ 探討「生物設計×人工智慧」如何重塑建築與城市未來★ 從都市微生物到地質尺度，拓展設計的時間與空間想像★ 結合實務案例與學術研究，提出設計作為「共生系統」的全新觀點在人工智慧與氣候危機交織的當代，設計的角色正快速轉變。本書《Biodesign in the Age of Artificial Intelligence: Deep Green》由創新設計團隊 ecoLogicStudio 主導，延續其前作《Systemic Architecture》，進一步提出「設計智慧」不僅屬於數位領域，也深植於生物系統之中。全書分為兩大部分：第一部分「PhotoSynthetica™」聚焦於都市尺度的應用，透過介入城市微生物生態系，發展能即時回應環境的設計方案；第二部分「Deep Green」則將視野擴展至更宏觀的時空尺度，探索合成地景與長時間演化過程，將設計視為一種影響地理與地質的力量。作者結合於 University of Innsbruck 與 UCL Bartlett School of Architecture 的研究成果，提出設計應被理解為一種延伸的認知介面——一個具有感知能力、能與地球生命系統共演化的存在。在無法簡單「逆轉」氣候變遷的現實下，本書主張我們應建立新的正向變化動能，讓建築與設計成為維繫地球美感與生命力的重要角色。這不僅是一本關於未來設計的書，更是一份重新思考人類、科技與自然關係的深刻提案。Biodesign in the Age of Artificial Intelligence: Deep Green investigates the potential of nature-based technology for shaping the evolution of contemporary architecture and design. It takes on the now pervasive topic of design intelligence, extending its definition to encompass both biological and digital realms.As in their first title, Systemic Architecture: Operating Manual for the Se

In today’s rapidly evolving digital landscape, safeguarding critical data and systems has never been more vital—or more challenging. Systematic Security: A CISO’s Playbook by Timur Qader offers a groundbreaking guide to building a resilient and scalable security practice from the ground up. Blending real-world experience with practical insights, this book lays out a phased approach to security implementation.Timur begins with describing the current state of security and the landscape security professionals find themselves in that offer both opportunity and risk. He goes on to systematically address strategic design, operational efficiency, risk-based modeling, and a rapidly growing regulatory landscape. This essential resource provides step-by-step strategies for implementing a comprehensive security framework. Whether you''re launching a new security program or transforming an existing one, this book delivers actionable insights on governance, compliance, and advanced security operati

The COVID-19 pandemic has affected the entire world in an unprecedented way and this book provides an overview of the historical facts as well as ongoing approaches to tackle the COVID-19 pandemic. Experts of the respective domains provide details on anti-SARS-COV-2 drug strategies, including repurposing drugs used for other indications and development of novel drugs looking at different approaches to target virus entry and replication. COVID-19 vaccine development based on inactivated and attenuated live virus, protein subunit and peptide-based vaccines and utilization of vaccine candidates based on viral vectors, DNA and RNA are presented for both preclinical studies and clinical trials.Key Features* Explains the background of the COVID-19 pandemic, the current progress in the development of treatments and prevention of COVID-19 including future aspects of dealing with pandemics. * Serves as a timely repository of knowledge on COVID-19 for researchers and medical professionals engage

Jazz Improvisation Using Simple Melodic Embellishment teaches fundamental concepts of jazz improvisation, highlighting the development of performance skills through embellishment techniques. Written with the college-level course in mind, this introductory textbook is both practical and comprehensive, ideal for the aspiring improviser, focused not on scales and chords but melodic embellishment. It assumes some basic theoretical knowledge and level of musicianship while introducing multiple techniques, mindful that improvisation is a learned skill as dependent on hard work and organized practice as it is on innate talent.This jargon-free textbook can be used in both self-guided study and as a course book, fortified by an array of interactive exercises and activities:musical examplesperformance exerciseswritten assignmentspractice gridsresources for advanced studyand more!Nearly all musical exercises-presented throughout the text in concert pitch and transposed in the appendices for E-fla

This book examines the ways in which sport for development and peace (SDP) offers an opportunity for entrepreneurship to take place through and within sport, and how innovation in the context of SDP c

Violent liminalities in Early Modern Culture is a methodologically innovative book combining the twin disciplines of queer theory and disability studies. It investigates the violence feared from, and directed at, inhabitants of the ‘betwixt and between’ spaces of early modern literature and culture.

Surfactant research explores the forces responsible for surfactant assembly and the critical industrial, medical, and personal applications, including viscosity control, microelectronics, drug stabilization, drug delivery, cosmetics, enhanced oil recovery, and foods. Surfactant Science and Technology: Retrospects and Prospects, "a Festschrift in honor of Dr. Kash Mittal," provides a broad perspective with chapters contributed by leaders in the fields of surfactant-based physical, organic, and materials chemistries.Many of the authors participated in a special symposium in Melbourne, Australia, honoring Kash Mittal's 100th edited book at the 18th Surfactants in Solution (SIS) meeting. Each chapter provides an overview of a specific research area, with discussions on past, present, and future directions. The book is divided into six parts.Part I reviews the evolution of theoretical models for surfactant self-assembly, and introduces a model for interpreting ion-specific effects on aggreg

Sixty years after its birth, Synthetic Aperture Radar (SAR) evolved as a key player of earth observation, and it is continually upgraded by enhanced hardware functionality and improved overall performance in response to user requirements. The basic information gained by SAR includes the backscattering coefficient of targets, their phases (the truncated distance between SAR and its targets), and their polarization dependence. The spatiotemporal combination of the multiple data operated on the satellite or aircraft significantly increases its sensitivity to detect changes on earth, including temporal variations of the planet in amplitude and the interferometric change for monitoring disasters; deformations caused by earthquakes, volcanic activity, and landslides; environmental changes; ship detection; and so on.Earth-orbiting satellites with the appropriate sensors can detect environmental changes because of their large spatial coverage and availability. Imaging from Spaceborne and Airbo

Statistics Explained, now in its fully revised Fourth Edition, is for students and researchers who wish to understand the statistical analyses used to analyse quantitative (numerical) research data in

This book documents the early impressions and initial responses of various stakeholders of the soccer world to the challenges of COVID-19 in 2020.

This book is a comprehensive treatise on infective and inflammatory pathologies of the cornea with corresponding clinical images and diagrammatic illustrations. Corneal infections and inflammations are a major cause of ocular morbidity and visual impairment. Early diagnosis and treatment can lead to improved visual outcome and quality of life.Both infectious (bacterial, fungal, viral and protozoan) and non-infectious keratitis that cause corneal vascularisation, scarring and vision loss are covered extensively. The illustrated clinical findings presented in the form of diagrams, photographs, cases and videos aim to serve as a practical teaching tool for fellows, trainees and practising ophthalmologists. KEY FEATURESFocuses on clinically relevant parts of corneal diseases, using illustrations with arrows indicating different pathologies and signsServes as a ready clinical compendium for trainees, fellows and ophthalmologistsExplores various corneal pathologies through a wealth of accomp