Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

這次他們意外離開了熟悉的課桌世界，跌入了未知的戶外。Pencil因一時興奮跌出書包，忠誠的Eraser也跟著前往。兩人得憑藉智慧、默契與些許忍者技巧，闖過校園外的重重阻礙，只為回到原本的位置。Fans of NARWHAL AND JELLY as well as PIZZA AND TACO, prepare to meet your new favorite duo: a pair of best friend school supplies! In the next adventure of this hilarious early-reader graphic novel series, Pencil and Eraser get lost outside the lines!Pencil and Eraser are on their way to their first ever karate class—well, their person Stella is and they are tagging along. When Pencil gets a little too excited practicing her ninja moves, she falls right out of Stella’s backpack and lands on the sidewalk! And naturally, Eraser has no choice but to follow her.Stranded all alone in the big wide world, these two buds will have to use their wits, charm, and of course their impressive ninja moves, to find the dojo and make it safely back into Stella’s backpack before class is over. Between squirrelly obstacles and flashy distractions, will the duo (ahem, Pencil) stay on the straight and narrow lon

LEARN EVENMORECOMMON SIGHT WORDS WITH DR. SEUSS! Sight words are a building block of reading success, and this fun and friendly workbook helps early readers ages 5 to 7 learn more than 120 essential ones. With lots of encouragement from familiar friends like the Cat in The Hat, it's perfect for kids in K-1, as well as older kids wanting extra reinforcement for reading fluency!Developed by education experts, this Dr. Seuss Workbook gives kids a fun and cheerfyl way to learn common high-frequency sight words! Sight words are words that kids learn to recognize automatically without needing to sound out the letters, that often need to be memorized. Together with phonics and decodable words, sight words are an essential part of early reading success.SIGHT WORDS LEVEL 2 presents a mix of the most common sight words from kindergarten and 1st grade classrooms. It's perfect for those ages, as well as for any young learner who needs extra reinforcement and practice with sight words that are a li

From the New York Times bestselling author of Girl in Pieces comes a stunning novel that Vanity Fair calls "impossibly moving" and "suffused with light". In this raw, deeply personal story, a teenaged girl struggles to find herself amidst the fallout of her brother's addiction in a town ravaged by the opioid crisis. For all of Emory's life she's been told who she is. In town she's the rich one--the great-great-granddaughter of the mill's founder. At school she's hot Maddie Ward's younger sister. And at home, she's the good one, her stoner older brother Joey's babysitter. Everything was turned on its head, though, when she and Joey were in the car accident that killed Candy MontClaire. The car accident that revealed just how bad Joey's drug habit was. Four months later, Emmy's junior year is starting, Joey is home from rehab, and the entire town of Mill Haven is still reeling from the accident. Everyone's telling Emmy who she is, but so much has changed, how can she be the same person?

A stolen watermelon...Dueling kites...A blond wig left at the scene of the crime...And a smashed wristwatch whose time has run out!These are just some of the ten brain-twisting mysteries that Encyclopedia Brown must solve by using his famous computerlike brain. Try to crack the cases along with him--the answers to all the mysteries are found in the back!

Having lost the key to their locker, Eric and Cam must find the key before their parents discover it is gone, in an early reader storybook that features short sentences, repetition, and plenty of clue

It's never too early for your first checkmate. International Master and top YouTube chess coach Levy Rozman (aka GothamChess) brings the world’s greatest game to its newest fans—babies!This adorable board book introduces little ones to the basics of chess: the names of the pieces, how they move, and what it takes to win. With bold, high-contrast illustrations designed to support a baby’s developing vision and growing mind, this charming little book is both brainy and beautiful. Whether you're raising the next grandmaster or just want something smart for storytime, Chess for Babies is a perfect first move.

This fan-favorite Gingerbread Man is cooking up something new in this graphic novel for the earliest readers!The Gingerbread Man’s class is back in the kitchen! They’re using shapes to make fun cookies and the Gingerbread Man knows just what to he wants to make—a new puppy! AKA a cookie’s best friend.But when the puppy comes to life and runs loose through the school, the class will have to come up with even more fun creations to lure him back home. Good thing this cookie sure knows how to have a ball!This Gingerbread Man’s series of graphic novels--published in both hardcover and paperback editions--is for the youngest readers, full of the hilarious rhymes and action-packed escapades kids know and love from his picture books.Series Overview: The Gingerbread Man is Loose in Graphic Novels!Spring 2024: Buttons on the Loose and Class Pet on the LooseFall 2024: Paper Airplanes on the LooseSpring 2025: New Friend on the Loose

UNLOCK READING SUCCESS AND LEARN SIGHT WORDS WITH DR. SEUSS! This delightfully friendly workbook helps kids ages 5 to 7 learn 120 need-to-know sight words for beginning readers. With familiar characters like the Lorax, plus more than 80 pages of fun activities, it's perfect for kindergartners, 1st graders, and any young reader who wants to improve their reading comprehension and fluency.Developed by education experts, this Dr. Seuss Workbook gives kids a fun and cheerful way to learn common high-frequency sight words! Sight words are words that kids learn to recognize automatically without needing to sound out the letters, often through repetition. Together with phonics and decodable words, sight words are an essential part of early reading success.SIGHT WORDS LEVEL 1 is perfect for kindergartners, 1st graders, and any young learner who needs extra reinforcement with the sight words commonly encountered in classrooms and at kindergarten reading levels.Packed with plenty of practice, th

From the #1 New York Times bestselling author of Girl in Pieces comes a raw, heart wrenching new novel about a teen girl facing down alcohol and the journey she must take to heal.Everyone in Bella’s life needs something from her. Her mom needs her to help around the house, her little sister needs her to tuck her in at night, her dad needs her to not make waves, her ex needs her to not be so much. The only person who never needed anything from her was her grandmother. She just needed her to be Bella, and now her grandmother is dead. There’s only one thing that dulls the pressure. Vodka, beer, peppermint schnapps--alcohol smooths the sharp edges of Bella’s life and makes it all so much easier. And what’s the big deal? Everyone drinks. And Bella knows she can stop whenever she wants--she just needs to get through Thanksgiving.But that night changes everything. A Thanksgiving party and too many drinks lands her, unconscious, on her front steps where her mother finds her in the early

Join Simon and Chester in their fifth and most daring adventure yet! A hilarious early graphic novel series for fans of The Bad Guys and Dog Man.The worst has happened: Chester has been sucked up by a ghost trap in an attempt to save his best friend Simon, who is a ghost.Chester's school friend, Amie, blames Simon — after all, if Chester wasn't trying to save him, he wouldn't have been sucked up. And Simon blames Amie — after all, if Amie's dad wasn't a ghost hunter, there wouldn't be a trap there in the first place.But these two sworn enemies are going to have to work together to save Chester before the containment unit is emptied . . . into the void! Will they save him in time? Will they change their minds about each other? Will Chester make some new ghoul friends while he's trapped? Read on to find out . . .

The #1 New York Times-bestselling third installment of the All Souls series, and the basis for the final season of “A Discovery of Witches,” coming soon to AMC+, Sundance Now, and Shudder.In The Book of Life Diana and Matthew time-travel back from Elizabethan London to make a dramatic return to the present—facing new crises and old enemies. At Matthew’s ancestral home, Sept-Tours, they reunite with the beloved cast of characters from A Discovery of Witches—with one significant exception. But the real threat to their future has yet to be revealed, and when it is, the search for Ashmole 782 and its missing pages takes on even more urgency.In the third volume of the All Souls series, Harkness deepens her themes of power and passion, family and caring, past deeds and their present consequences. In palatial homes and university laboratories, using ancient knowledge and modern science, from the hills of the Auvergne to Venice and beyond, the couple at last learn what the witches discovered s

From patriotic songs that stir the soul to cowboy songs of early settlers, this is a terrific collection of songs about America. Children can learn as they hear “The Star Spangled Banner,” the names

Ocean Vuong returns with a big-hearted novel about chosen family, unexpected friendship, and the stories we tell ourselves in order to survive One late summer evening in the post-industrial town of East Gladness, Connecticut, nineteen-year-old Hai stands on the edge of a bridge in pelting rain, ready to jump, when he hears someone shout across the river. The voice belongs to Grazina, an elderly widow succumbing to dementia, who convinces him to take another path. Bereft and out of options, he quickly becomes her caretaker. Over the course of the year, the unlikely pair develops a life-altering bond, one built on empathy, spiritual reckoning, and heartbreak, with the power to alter Hai’s relationship to himself, his family, and a community at the brink. Following the cycles of history, memory, and time, The Emperor of Gladness shows the profound ways in which love, labor, and loneliness form the bedrock of American life. At its heart is a brave epic about what it means to exis

A GOOD MORNING AMERICA BOOK CLUB PICK“Sweeping and epic…An impactful love story, told against the backdrop of historical events…One of the best debut novels of this century.”—Pittsburgh Post-Gazette“Like any tried-and-true epic (think “Pachinko” or “The Joy Luck Club”)… Homeseeking is just a genuine pleasure to read.”—San Francisco ChronicleA single choice can define an entire life.Haiwen is buying bananas at a 99 Ranch Market in Los Angeles when he looks up and sees Suchi, his Suchi, for the first time in sixty years. To recently widowed Haiwen it feels like a second chance, but Suchi has only survived by refusing to look back.Suchi was seven when she first met Haiwen in their Shanghai neighborhood, drawn by the sound of his violin. Their childhood friendship blossomed into soul-deep love, but when Haiwen secretly enlisted in the Nationalist army in 1947 to save his brother from the draft, she was left with just his violin and a note: Forgive me.Homeseeking follows the separated lover

From bestselling author, life coach, and sociologist Martha Beck comes a new path to overcoming anxiety by awakening the creativity within.AN OPEN FIELD PUBLICATION FROM MARIA SHRIVERMost of us assume that the key to overcoming anxiety is to think our way out of it. And for a while, it works. Meditation and mental exercises offer us relief, but there is always something—a work deadline, a family emergency, a particularly distressing newsbreak—that disrupts our sense of peace and sends us right back inside the same anxious spiral we’ve been trying to climb out of.Is there a way to reduce our anxiety, not just in the moment, but in every moment after that?After a lifetime of struggling with anxiety, Martha Beck studied just about everything there was to know about how to calm down. What she realized is that the analytical part of our brain—so valued in Western culture—is the same structure responsible for amping up anxiety. In other words, we cannot logic our way to relief. InBeyond Anxi

Bestselling author Ruth Reichl takes readers on an adventure of food, art, and fashion in 1980s Paris in this dazzling, heartfelt novelStella reached for an oyster, tipped her head and tossed it back. It was cool and slippery, the flavor so briny it was like diving into the ocean... Oysters, she thought, where have they been all my life?When her estranged mother dies, Stella is left with an unusual a one-way plane ticket and a note reading Go to Paris . But Stella is hardly cut out for adventure; a childhood trauma has kept her confined to the strict routines of her comfort zone. When her boss encourages her to take time off, Stella resigns herself to honoring her mother’s last wishes.Alone in a foreign city, Stella falls into old habits, living cautiously and frugally. Then she stumbles across a vintage store where she tries on a fabulous Dior dress. The shopkeeper insists that this dress was meant for Stella and, for the first time in her life, Stella does something impulsive. She bu

Get lost in the newest fantasy from the author ofA Hunger of Thorns, on a beguiling journey behind the closed doors of a sinister secret society. Featuring a steamy enemies-to-lovers romance and a fight for the witching world that will get your heart racing.Merry doesn’t need a happily-ever-after. Her life in the charming, idyllic town of Candlecott is fine just as it is. Simple, happy, and with absolutely no magic. Magic only ever leads to trouble.But Merry’s best friend, Teddy, is joining the Toadmen—a secret society who specialize in backward thinking and suspiciously supernatural traditions—and Merry is determined to stop him. Even if it means teaming up with the person she hates most: her academic archnemesis, Caraway Boswell, an ice-cold snob who hides his true face under a glamour.An ancient Toad ritual is being held in the sinister Deeping Fen, and if Merry doesn’t rescue Teddy before it’s finished, she’ll lose him forever. But the Toadmen have been keeping dangerous secrets, a

In Silverview, John le Carré turns his focus to the world that occupied his writing for the past sixty years―the secret world itself.Julian Lawndsley has renounced his high-flying job in the City for a simpler life running a bookshop in a small English seaside town. But only a couple of months into his new career, Julian’s evening is disrupted by a visitor. Edward, a Polish émigré living in Silverview, the big house on the edge of town, seems to know a lot about Julian’s family and is rather too interested in the inner workings of his modest new enterprise.When a letter turns up at the door of a spy chief in London warning him of a dangerous leak, the investigations lead him to this quiet town by the sea . . .Silverview is the mesmerizing story of an encounter between innocence and experience and between public duty and private morals. In this last complete masterwork from the greatest chronicler of our age, John le Carré asks what you owe to your country when you no longer recognize i

BOOK ONE IN THENEW YORK TIMESBESTSELLING SERIES • One ofTime Magazine’s 100 Best Fantasy and 100 Best YA Books of All Time • People's Choice Award winner • Bustle's Best Young Adult Book“This novel is a harrowing, haunting reminder of what it means to be human—and how hope might be kindled in the midst of oppression and fear.” —The Washington PostThe beloved and bestselling fantasy series that “glows, burns, and smolders.” (Huffington Post).Laia is a slave.Elias is a soldier.Neither is free.Under the Martial Empire, defiance is met with death. Those who do not vow their blood and bodies to the Emperor risk the execution of their loved ones and the destruction of all they hold dear.It is in this brutal world, inspired by ancient Rome, that Laia lives with her grandparents and older brother. The family ekes out an existence in the Empire’s impoverished backstreets. They do not challenge the Empire. They’ve seen what happens to those who do.But when Laia’s brother is arrested for treason,

The true, behind-the-scenes history of the people who built Silicon Valley and shaped Big Tech in America Long before Margaret O'Mara became one of our most consequential historians of the American-led digital revolution, she worked in the White House of Bill Clinton and Al Gore in the earliest days of the commercial Internet. There she saw firsthand how deeply intertwined Silicon Valley was with the federal government--and always had been--and how shallow the common understanding of the secrets of the Valley's success actually was. Now, after almost five years of pioneering research, O'Mara has produced the definitive history of Silicon Valley for our time, the story of mavericks and visionaries, but also of powerful institutions creating the framework for innovation, from the Pentagon to Stanford University.It is also a story of a community that started off remarkably homogeneous and tight-knit and stayed that way, and whose belief in its own mythology has deepened into a collective

The critically acclaimed, instant #1 bestseller by John Green, author of The Anthropocene Reviewed and The Fault in Our StarsNOW STREAMING ON MAX!John Green’s critically acclaimed, instant #1 bestseller, now in paperback“Wrenching and revelatory,” -The New York TimesAza never intended to pursue the mystery of fugitive billionaire Russell Pickett, but there’s a hundred-thousand-dollar reward at stake and her Best and Most Fearless Friend, Daisy, is eager to investigate. So together, they navigate the short distance and broad divides that separate them from Pickett’s son Davis.Aza is trying. She is trying to be a good daughter, a good friend, a good student, and maybe even a good detective, while also living within the ever-tightening spiral of her own thoughts.John Green, the acclaimed, award-winning author of Looking for Alaska and The Fault in Our Stars, shares Aza’s story with shattering, unflinching clarity in this brilliant novel of love, resilience, and the power of lifelong frien

THE #1 NEW YORK TIMES BESTSELLING SEQUEL TO AN EMBER IN THE ASHESA USA TODAY BESTSELLERA WALL STREET JOURNAL BESTSELLER“Spectacular.”—Entertainment Weekly“Fresh and exciting...Tahir has shown a remarkable talent for penning complex villains.”—A.V. Club"Even higher stakes than its predecessor… thrilling." —Publishers Weekly, starred review“[An] action-packed, breathlessly paced story.” —Booklist, starred reviewSet in a rich, high-fantasy world inspired by ancient Rome, Sabaa Tahir's AN EMBER IN THE ASHES told the story of Laia, a slave fighting for her family, and Elias, a young soldier fighting for his freedom. Now, in A TORCH AGAINST THE NIGHT, Elias and Laia are running for their lives.After the events of the Fourth Trial, Martial soldiers hunt the two fugitives as they flee the city of Serra and undertake a perilous journey through the heart of the Empire. Laia is determined to break into Kauf—the Empire’s most secure and dangerous prison—to save her brother, who is the ke

Is Demon up to the challenge?Beasts of Olympus is a series of illustrated chapter books set in a magical Ancient Greece where strange things still walk the Earth. In the fifth book, Chiron the centaur teaches Demon to make his own cures for sick mythical beasts. But Demon must put his new skills to the test right away in order to save an ailing phoenix before it's too late!

Here is Edgar Award Winner Dori Hillestad Butler's seventh title in her not-too-scary chapter book mystery series, The Haunted Library. Perfect for reluctant readers in the mood for a great mystery!A

Demon’s abilities are put to the test!Beasts of Olympus is a series of illustrated chapter books set in a magical Ancient Greece where strange things still walk the Earth. In the fourth book, Demon must heal Ares’s smelly dragon in time for battle. Can he heal this sick beast before Olympus chokes on the stink?

The exhilarating fourth installment in this thrilling epic for middle graders!The kingdom of Lyssia remains ravaged by war. Drew, the rightful heir to the werelord throne, is locked in battle against

Fun in the sun with Llama Llama! Read along with Llama Llama as he splashes in the waves and plays in the sand in this brand-new touch-and-feel board book! This book is an incredible buy at only $12.

With one bite of his magic bone, Sparky lands in the Amazon Rain Forest in Brazil among biting bugs and dogs with . . . webbed feet!? The Bush Dogs declare him their new leader when he saves their hom

Kaz and Claire are back for a timely mystery in this adorable series by Edgar Award winner Dori Hillestad Butler!Kaz and Claire are called in for another ghostly mystery, and this ghost is always righ

In this funny historical picture book, a family of misbehaving children get George Washington to finally smile—just in time for his portrait!Charlotte, James, and baby John have promised to be on thei

A final entry in the celebrated series that includes In a Glass Grimmly combines eerie landscapes and fear-inducing characters in a latest adventure featuring an irreverent narrator who provides dark

"A hilarious pictorial parody of a clueless father and his adorable daughter. In an attempt to create an image that his new daughter would one day appreciate, Dave Engledow took a photo in which he's

Theodore Boone is back in action! As all of Strattenburg sits divided over a hot political and environmental issue, Theo finds himself right in the thick of it. The county commission is fighting hard

Hoping to escape the cold in his backyard, Sparky chomps on his magic bone--only to find himself in snowy Zermatt, Switzerland. He befriends Lena, a Saint Bernard rescue dog with a terrible sense of d

The brilliant and acclaimed New York Times bestseller from the author of The Women and When the Killing’s Done Just off the coast of Southern California, two families—one in the 1880s and one in the

Now that he's won the chocolate factory, what's next for Charlie?Last seen flying through the sky in a giant elevator in Charlie and the Chocolate Factory, Charlie Bucket's back for another adventure.

When a tornado hits her farmhouse in Kansas, Dorothy is caught up in a whirlwind of adventure, complete with flying monkeys, talking lions, and silver slippers. Advanced readers will join Dorothy, Tot

The Caldecott Honor book and modern classic now in boardbook format. Finally!Nearly twenty years ago, Ed Young translated the ancient parable of the seven blind men and the elephant into a modern children's classic, one as simple as it is profound. A lesson in colors, numbers, the days of the week and most important, knowledge, this beautifully illustrated book has stood the test of time and continues to entertain and teach. Now in board book format, even the youngest children can experience the beauty and wisdom.

Bright, primary colors and big cookie shapes make this beloved book about a baker perfect for the very youngest. In twelve scrumptious spreads, Mr. Cookie Baker shows all the steps in preparing his fa

"Since it was first published in 1981 Getting to Yes has become a central book in the Business Canon: the key text on the psychology of negotiation. Its message of "principled negotiations"--finding a