Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Ranking alongside George R. R. Martin as a groundbreaking master of fantasy,New York Times bestselling author Robin Hobb delivers the second book in her long-awaited Fitz and the Fool trilogy.The harr

GAME OF THRONES: A NEW ORIGINAL SERIES, NOW ON HBO.Few books have captivated the imagination and won the devotion and praise of readers and critics everywhere as has George R. R. Martin’s monumental e

"California, Labor Day weekend . . . early, with ocean fog still in the streets, outlaw motorcyclists wearing chains, shades and greasy Levis roll out from damp garages, all-night diners and cast-off

From the creators of National Geographic Kids’ wildly successfulGreeking Outpodcast, thisNew York Timesbest-selling tie-in book delivers a clever tongue-in-cheek retelling of 20 classic Greek myths.Greeking Out #1-3 (共3本)

本書是 Geisel 獎得主 Greg Pizzoli 的全新橋樑書系列，以輕快幽默的節奏，描寫兩位性格南轅北轍的鄰居──樂天的鳥兒 Earl 和喜歡安靜閱讀的 Worm。他們的友誼一開始並不順利：一方熱愛清晨的音樂，另一方則嚮往寧靜。但透過一杯檸檬水、一面牆的顏色、一首尚未寫完的詩，以及願意分享彼此的小故事，他們慢慢建立起難得的情誼。全書收錄三個短篇故事，節奏輕快，文字簡潔，特別適合剛從《Elephant and Piggie》畢業的初階讀者，笑聲與溫度兼具，是閱讀橋接期的理想選擇This giggle-inducing early reader kicks off a brand-new series featuring two unlikely friends, for fans of Frog and Toad, from beloved Geisel Award-winning author of The Watermelon Seed.Earl and Worm have been friends for a very, very long time, but their friendship had a rocky start. Earl is a happy go-lucky bird who plays saxophone to his plants because they love music in the morning. His neighbor Worm, on the other hand...well, Worm is the exact opposite. She would rather read in silence.How will these very different neighbors become the very best of friends? With some sweet lemonade, the right shade of paint, and an unfinished poem, and most of all, sharing a little bit about themselves.Award-winning creator Greg Pizzoli delivers three funny

For fans of The Hunger Games, Divergent, and Red Rising comes a gripping sci-fi adventure in which a group of teenagers wake up in a mysterious corridor with no knowledge of who they are or how they g

"The newest installment in the beloved and best-selling series. In this delightful fifteenth installment, Mma Ramotswe has her hands full both at home and in the office. To add to her current challeng

A sophisticated vegetarian cookbook with all the tools you need to be at home in your kitchen, cooking in the most nourishing and delicious ways--from the foundations of stocking a pantry and under

In his international blockbusters The Da Vinci Code, Angels & Demons, and The Lost Symbol, Dan Brown masterfully fused history, art, codes, and symbols. In this riveting new thriller, Brown return

Truman Capote’s masterpiece, In Cold Blood, created a sensation when it was first published, serially, in The New Yorker in 1965. The intensively researched, atmospheric narrative of the lives of the

From the Modern Library’s new set of beautifully repackaged hardcover classics by Truman Capote—also available are In Cold Blood, Portraits and Observations, and The Complete StoriesTogether in one vo

NATIONAL BESTSELLER • Most fairytales end with a wedding and a happily-ever-after—but this is no fairytale. The updated and official translation ofUnder the Oak Tree, the #1 webnovel on MANTA, continues in this second volume.The gorgeous first edition hardcover ofUnder the Oak Tree: Volume 2 (The Novel)will feature designed sprayed page edges, full-color patterned endpapers, foil stamping on the cover, and a ribbon bookmark!As her first winter in Anatol turns to spring, Lady Maximilian finds herself confronting an unfamiliar feeling: hope. Her voice and her magic strengthen every day; the only parts of Calypse Castle left to refurbish are its gardens, which she plans to fill with blooming flowers; and the way her husband, the recalcitrant war hero Sir Riftan, looks at her from across their bedroom makes her feel, for the first time in her life, that she might be worthy of love and affection.However, Maxi's life is never that easy. Just as she begins to feel at home with Riftan, Maxi re

本書由 National Geographic Kids 系列 Greeking Out 團隊打造，以輕鬆幽默的筆調，帶來20則來自世界各地的冥界故事。從希臘冥后被綁架的傳說，到埃及死神衡量心靈重量的試煉，再到北歐曲折的死亡之路，讀者能在驚悚與趣味之間，窺見古文明如何理解生死。插畫俏皮，搭配「Wi-Fi神諭者」的旁白，使艱深的神話變得易於親近。本書不僅提供神話奇談，更展現跨文化對死亡的想像，孩子與大人都適讀。Hold on tight as Greeking Out goes to the dark side, bringing you scary (and surprisingly funny) tales of life, death, and everything in between! Get ready for 20 bone-chilling stories of the Underworld--from ancient Greece and around the world--as told by the team behind the smash-hit podcast and New York Times best-selling book series. Venture to the edge of life itself from the safety of your living room! In these stories, you'll encounter a very ill-advised bid to kidnap the queen of the Underworld, an Egyptian god of death who weighs your heart against a feather, the treacherous and winding road to the Norse afterlife, and much more. Tales of fearsome gods, fantastical monsters, and literally death-defying heroes of the spirit world are told in the hilarious, kid-friendly voice

Oh, Muses! Get ready for 20 brand-new, tongue-in-cheek tales from Greek mythology, as told by the team behind the smash hit podcast and New York Times best-selling book Greeking Out.Want to know the greatest feats and the funniest secrets of the gods and heroes of Greek mythology? You’re in the right place. Told in the hilarious, kid-friendly voice that’s sent the Greeking Out podcast to the top of the charts, these stories of heroic victories, perilous adventures, and plain old mischief are sure to delight kids and adults alike. Plus, fans of the Percy Jackson series will love discovering the real myths behind their favorite (and least favorite) characters.In this book, you’ll encounter a god kidnapped by pirates, sheep used as camouflage, a super-shiny fleece, some dangerous metalworking, the world’s most perfect animal, a really heavy boulder, and much more.Dynamic, playful illustrations coupled with laugh-out-loud storytelling and real information about ancient Greece—delivered by

"Milo Andret, the genius who solved the Malosz Conjecture and won the Fields Medal for mathematics, had an unusual, even eerie mind from birth, but not until he moves to Berkeley in the 1970s to pursu

The highly anticipated new standalone full-color graphic novel from Bryan Lee O’Malley, author and artist of the hugely bestselling Scott Pilgrim graphic novel series.Advance praise for Seconds “In S

Expanded and updated exclusively for graduates just entering the workforce, this extraordinary edition of Lean In includes a letter to graduates from Sheryl Sandberg and six additional chapters from e

An intimate, voyeuristic exploration into the private landscape of the unconscious from the Muybridge of sleep. In 1975, Ted Spagna began his voyeuristic venture into "inner space," exposing the se

An instant American icon--the first Hispanic on the U.S. Supreme Court--tells the story of her life before becoming a judge in an inspiring, surprisingly personal memoir.With startling candor and inti

The newest Oprah's Book Club 2.0 selection. The arrival of a major new voice in contemporary fiction. A debut of extraordinary distinction: Ayana Mathis tells the story of the children of the Great

Pilgrimage took Annie Leibovitz to places that she could explore with no agenda. She wasn’t on assignment. She chose the subjects simply because they meant something to her. The first place was Emily Dickinson’s house in Amherst, Massachusetts, which Leibovitz visited with a small digital camera. A few months later, she went with her three young children to Niagara Falls. “That’s when I started making lists,” she says. She added the houses of Virginia Woolf and Charles Darwin in the English countryside and Sigmund Freud’s final home, in London, but most of the places on the lists were American. The work became more ambitious as Leibovitz discovered that she wanted to photograph objects as well as rooms and landscapes. She began to use more sophisticated cameras and a tripod and to travel with an assistant, but the project remained personal. Leibovitz went to Concord to photograph the site of Thoreau’s cabin at Walden Pond. Once she got there, she was drawn into the wider world of the C

The smell of a pie baking in the kitchen immediately conjures up feelings of comfort, nostalgia, and love. Michele Stuart vividly remembers standing at her grandmother’s apron hem as a child, as she f

Most readers know Truman Capote as the author of Breakfast at Tiffany’s and In Cold Blood; or they remember his notorious social life and wild and witty public appearances. But he was also the author

This successor volume to The Hidden Origins of Islam (edited by Karl-Heinz Ohlig and Gerd-R. Puin) continues the pioneering research begun in the first volume into the earliest development of Islam. U

This graphic novel adaptation contains more than fifty pages of exclusive content not available in the original comic books, including‧ a new Preface by George R. R. Martin‧ early renderings of key sc

In a handful of years between the development of electrical recording in 1925 and the outset of the Great Depression in the early 1930s, the soundscape of modern music unfolded in a series of relative

A hands-on science book packed with fun experiments from rockstar science educator Carmelo the Science Fellow! Designed to encourage kids' natural love of science from an early age, this book promotes

A unique approach to the history of science using do-it-yourself experiments along with brief historical profiles to demonstrate how the ancient alchemists stumbled upon the science of chemistry.Be th

A stand-alone entry in the Shannara series finds Paxon Leah attempting to rescue his kidnapped sister using a seemingly insignificant family sword only to uncover a plot to overthrow the Druids, who r

What happens when two cartoonists for The New Yorker fall in love and marry? Lots of witty wordplay, skewering drawings, and a healthy dose of illustrative competition. For twenty years, veteran carto

Using both canonical and noncanonical primary texts, Ludemann (history and literature of early Christianity, U. of Gottingen) presents evidence that the resurrection was not a historical event and arg

The early fiction of one of the nation’s most celebrated writers, Truman Capote, as he takes his first bold steps into the canon of American literatureRecently discovered as manuscript pages in the ar

In the grand tradition of George R. R. Martin, Terry Brooks, David Eddings, and Robert Jordan, New York Times bestselling author Peter V. Brett continues his critically acclaimed Demon Cycle, which la

"Richard McGuire's Here is the story of a corner of a room and the events that happened in that space while moving forward and backward in time. The book experiments with formal properties of comics,

A penultimate entry in the series that includes the best-selling Hitler's War builds on the events of the previous four novels to reimagine a desperate Nazi response to a war on two fronts from the pe

Long before A Game of Thrones became an international phenomenon, #1 New York Times bestselling author George R. R. Martin had taken his loyal readers across the cosmos. Now back in print after almost

Drug dealers, hustlers, brothels, dirty politics, corrupt cops . . . and sorcery. Welcome to Low Town. In the forgotten back alleys and flophouses that lie in the shadows of Rigus, the finest city of

Drawing on both their own fieldwork from 1991 to 1999 and older written sources, Stewart and Strathern explore how the Duna have remade their rituals and associated myths in response to the outside in

The incredible true story of the decade-long quest to bring down Paul Le Roux—the creator of a frighteningly powerful Internet-enabled cartel who merged the ruthlessness of a drug lord with the techno

Reminiscent of the early work of Jhumpa Lahiri, Ayelet Tsabari’s award-winning debut collection of stories is global in scope yet intimate in feel, beautifully written, and emotionally powerful. From