Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

A dead girl, a wealthy family, and indications of drug use. It's a toxic mix that leads Philadelphia detective Matt Payne deep into an unexpected maelstrom of deceit and madness in the latest entry in

Embarking on her freshman year at Harvard in the early tech days of the 1990s, a young artist and daughter of Turkish immigrants begins a correspondence with an older mathematics student from Hungary

Few authors have understood the tender intricacies of relationships better than the incomparable Belva Plain. For three decades her deeply moving epics have captivated the hearts and imaginations of r

"Just because the men have gone to war, why do we have to close the choir? And precisely when we need it most!" As England enters World War II's dark early days, spirited music professor Primrose T

At once wildly original and stuffed with irresistible nostalgia, READY PLAYER ONE is a spectacularly genre-busting, ambitious, and charming debut—part quest novel, part love story, and part virtual space opera set in a universe where spell-slinging mages battle giant Japanese robots, entire planets are inspired by Blade Runner, and flying DeLoreans achieve light speed.It’s the year 2044, and the real world is an ugly place. Like most of humanity, Wade Watts escapes his grim surroundings by spending his waking hours jacked into the OASIS, a sprawling virtual utopia that lets you be anything you want to be, a place where you can live and play and fall in love on any of ten thousand planets. And like most of humanity, Wade dreams of being the one to discover the ultimate lottery ticket that lies concealed within this virtual world.For somewhere inside this giant networked playground, OASIS creator James Halliday has hidden a series of fiendish puzzles that will yield massive fortune—and r

"A gripping and poignant ode to a messy, loving family in all its glory."--Madeline MillerA dazzling, multigenerational novel in which the four adult daughters of a Chicago couple--still madly in love

The final wish of a dying friend leads Jack Ryan, Jr. to the jungles of South America where an unexpected confrontation will have shocking international repercussions in this latest entry in the New Y

From the bestselling and award-winning master of suspense, the first novel in a thrilling new series, introducing Colter Shaw."You have been abandoned."A young woman has gone missing in Silicon Valley

In the new edge-of-your-seat adventure from national bestselling author Nick Petrie, Peter Ash pursues one case--and stumbles into another--in the City of the Blues.Iraq war veteran Peter Ash is restl

Stephanie Plum faces the toughest puzzle of her career in the twenty-fifth entry in Janet Evanovich's #1 New York Times-bestselling series. There's nothing like a good deli, and the Red River Deli in

A brilliant new work of suspense from "the most important crime novelist to emerge in the past 10 years." (Washington Post)From the writer who "inspires cultic devotion in readers" (The New Yorker) and has been called "incandescent" by Stephen King, "absolutely mesmerizing" by Gillian Flynn, and "unputdownable" (People), comes a gripping new novel that turns a crime story inside out.Toby is a happy-go-lucky charmer who's dodged a scrape at work and is celebrating with friends when the night takes a turn that will change his life - he surprises two burglars who beat him and leave him for dead. Struggling to recover from his injuries, beginning to understand that he might never be the same man again, he takes refuge at his family's ancestral home to care for his dying uncle Hugo. Then a skull is found in the trunk of an elm tree in the garden - and as detectives close in, Toby is forced to face the possibility that his past may not be what he has always believed.A spellbinding standalone

A weekend retreat at a cozy mountain lodge is supposed to be the perfect getaway . . . but when the storm hits, no one is getting awayIt's winter in the Catskills and Mitchell's Inn, nestled deep in t

The overlooked middle sister in Jane Austen’s Pride and Prejudice casts off her prim exterior and takes center stage in this fresh retelling of the classic novel. I will tell you the stor

A shocking discovery on a honeymoon in paradise changes the lives of a picture-perfect couple in this taut psychological thriller debut—for readers of Ruth Ware, Paula Hawkins, and Shari Lapena.

In this twisty psychological thriller from the New York Times bestselling author of The Girl Before, an actress plays both sides of a murder investigation. A struggling actor, a Brit in America

Isabel becomes involved in a delicate paternity case in the twelfth installment of the beloved Isabel Dalhousie Series.Isabel finds herself befriended by Patricia, a single mother whose son, Basil, go

In a new novel from New York Times bestselling author Bryan Reardon, a suburban family is rocked in the wake of a terrorist attack on American soil.On a typical late summer day, Julia Swann is on the

Jack Ryan Jr. finds that the scars of war can last a lifetime in the latest entry in Tom Clancy's #1 New York Times bestselling series.Twenty years ago, Dr. Kathy Ryan restored the eyesight of a young

Charts the largely unexplored realities of being a 40-something in today's world, in a latest collection of laugh-out-loud essays that examines the decade as a milestone less associated with midlife t

A hypnotic domestic noir novel in which a house swap becomes the eerie backdrop to a crumbling marriage and tantalizing affair, and the fatal consequences that unfoldBe careful who you let in...When C

The compulsively readable, behind-the-scenes memoir that takes listeners inside the Obama White House, through the eyes of a young staffer learning the ropes, falling in love, and finding her place in

Pulitzer Prize–winning author Jon Meacham helps us understand the present moment in American politics and life by looking back at critical times in our history when hope overcame division and fe

From the author of the Pulitzer Prize-winning bestseller DEVIL IN THE GROVE, a gripping story of sex, race, class, corruption, and the arc of justice twisted and bent straight again in the Florida cit

Lucas Davenport confronts an old nemesis, now more powerful than ever as a U.S. senator, in the thrilling new novel in the #1 New York Times-bestselling Prey seriesLucas Davenport had crossed paths wi

A HEART-POUNDING NEW THRILLER FROM THE AUTHOR OF THE SNOWMAN AND THE THIRST Set in the 1970s in a run-down, rainy industrial town, Jo Nesbo's Macbeth centers around a police force struggling to s

From two visionary thinkers and practitioners comes a big idea about how power works differently in our hyperconnected age.Why do some leap ahead while others fall behind in today's chaotic, connected

The tensions in a tight-knit neighborhood—and a seemingly happy marriage—are exposed by an unexpected act of violence in this provocative new novel from the #1 New York Times bestselling a

From the New York Times bestselling author of The Guest Room, a powerful story about the ways an entire life can change in one night: a flight attendant wakes up in the wrong hotel, in the wrong bed,

In 1789, Alexander Mackenzie traveled the 1125 miles of the immense river in Canada that now bears his name, in search of the fabled Northwest Passage, only to confront impassable pack ice. In 2016, t

Murder, sunken treasure, and pirates both ancient and modern send Doc Ford on a nightmare quest in the thrilling new novel in the New York Times-bestselling series.Marine biologist Doc Ford has been k

The Gray Man is back in another nonstop international thriller from #1 New York Times bestselling coauthor of Tom Clancy's Jack Ryan novelsCourt Gentry is back in action. This time he's working on beh

A disturbing murder with shocking consequences sets in motion the new book in the #1 bestselling suspense series starring psychologist Alex Delaware and Detective Milo Sturgis.An affluent family retur

In #1 New York Times bestselling author Lisa Gardner's latest twisty thrill ride, Detective D.D. Warren and Find Her's Flora Dane return in a race against the clock to either save a young girl's life

In the spirit of Lilac Girls, the heartbreaking history of Korea is brought to life in this deeply moving and redemptive debut that follows two sisters separated by World War II. Korea, 1943. Han

From #1 New York Times bestselling author Danielle Steel, Past Perfect is a spellbinding story of two families living a hundred years apart who come together in time in a startling moment, opening the

As seen in the new movie The Post, here is the captivating, inside story of the woman who helmed the Washington Post during one of the most turbulent periods in the history of American media

A warm, wry, sharply observed debut novel about what happens when a family is forced to spend a week together in quarantine over the holidays...It’s Christmas, and for the first time in years th

Class reunions: a time for memories--good, bad, and, as Virgil Flowers is about to find out, deadly--in the thrilling new novel in the #1 New York Times-bestselling series Virgil knows the town of Tri

Camille Lammenais has grown up in the beauty of the Napa Valley, surrounded by acres of her family’s vineyards. Her parents, Christophe and Joy, still deeply in love after two decades of ma

From the author of the #1 international best seller The Girl in the Spider's Web: the new book in the Millennium series, which began with Stieg Larsson's The Girl with the Dragon Tattoo Lisbeth Saland