Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

2015 Pulitzer Prize for Fiction2015 Andrew Carnegie Medal for Excellence in FictionWinner of the Pulitzer Prize, a New York Times Book Review Top Ten Book, National Book Award finalist, more than two and a half years on the New York Times bestseller listFrom the highly acclaimed, multiple award-winning Anthony Doerr, the stunningly beautiful instant New York Times bestseller about a blind French girl and a German boy whose paths collide in occupied France as both try to survive the devastation of World War II.Marie-Laure lives in Paris near the Museum of Natural History, where her father works. When she is twelve, the Nazis occupy Paris and father and daughter flee to the walled citadel of Saint-Malo, where Marie-Laure’s reclusive great uncle lives in a tall house by the sea. With them they carry what might be the museum’s most valuable and dangerous jewel.In a mining town in Germany, Werner Pfennig, an orphan, grows up with his younger sister, enchanted by a crude radio they find that

You may be surprised to learn that microchips are the new oil—the scarce resource on which the modern world depends. Today, military, economic, and geopolitical power are built on a foundation of computer chips. Virtually everything—from missiles to microwaves—runs on chips, including cars, smartphones, the stock market, even the electric grid. Until recently, America designed and built the fastest chips and maintained its lead as the #1 superpower, but America’s edge is in danger of slipping, undermined by players in Taiwan, Korea, and Europe taking over manufacturing. Now, as Chip War reveals, China, which spends more on chips than any other product, is pouring billions into a chip-building initiative to catch up to the US. At stake is America’s military superiority and economic prosperity.Economic historian Chris Miller explains how the technology works and why it’s so important, recounting the fascinating events that led to the United States perfecting the chip design, and to Ameri

In her extraordinary bestseller, Adrian Nicole LeBlanc immerses readers in the intricacies of the ghetto, revealing the true sagas lurking behind the headlines of gangsta glamour, gold-drenched drug

Tracing the development of American cities and city life from early colonial settlements to the familiar downtowns of today, a sweeping cultural history reveals how our urban spaces have been shaped b

In this debut novel, “a crisp, exciting exploration of love, friendship, and everything in between” (Kirkus Reviews), longtime romantic partners Kathryn and Chris experiment with an open r

After Alexander Lawson -- a rising star on Northern Ireland's police force at twenty-four -- is assigned to the corruption-ridden drug squad, he becomes addicted to heroin under unusual circumstances

The restored edition of Hemingway's classic memoir of his early life in Paris.

Ellen Sandbeck is an organic landscaper, worm wrangler, writer, and graphic artist who lives with (and experiments on) her husband and an assortment of younger creatures -- which includes two mostly

When Witold Rybczynski first heard about New Daleville, it was only a developer's idea, attached to ninety acres of cornfield an hour and a half west of Philadelphia. Over the course of five years, R

Early in 2004, two writers and Red Sox fans, Stewart O'Nan and Stephen King, decided to chronicle the upcoming season, one of the most hotly anticipated in baseball history. They would sit together a

First published in 1927, Men Without Women represents some of Hemingway's most important and compelling early writing. In these fourteen stories, Hemingway begins to examine the themes that would occu

The Mind/Body ConnectionMillions of readers are familiar with the work of Dr. Herbert Benson and the Mind/Body Medical Institute from the mega-bestselling book The Relaxation Response. With over thre

From New York Times bestselling author of The Gentle Art of Swedish Death Cleaning, a book of humorous and charming advice for embracing life and aging joyfully.Margareta Magnusson shared with the world her practical Swedish tradition of dstdning, or ';death cleaning'clearing out unnecessary belongings before others must do it for youin her international bestseller The Gentle Art of Swedish Death Cleaning. Now, unburdened by baggage (emotional and actual) she is able to focus on what makes each day worth living, and reveals her discoveries about growing oldersome difficult to accept, many rather wondrous. She reflects on her early days growing up in Sweden and raising her family around the world, offering tips and wisdom on how to age gracefully, such as: don't be afraid to wear stripes, don't resist new technology, let go of what doesn't matter, and much more. As with death-cleaning, it's never too early to begin and The Swedish Art of Aging Well shows us how to prepare for and unders

In the tradition of Silent Spring and The Sixth Extinction, an urgent, "disturbing, empowering, and essential" (Kirkus Reviews, starred review) book about the ways in which chemicals in the modern environment are changing--and endangering--human sexuality and fertility on the grandest scale, from renowned epidemiologist Shanna Swan. In 2017, author Shanna Swan and her team of researchers completed a major study. They found that over the past four decades, sperm levels among men in Western countries have dropped by more than 50 percent. They came to this conclusion after examining 185 studies involving close to 45,000 healthy men. The result sent shockwaves around the globe--but the story didn't end there. It turns out our sexual development is changing in broader ways, for both men and women and even other species, and that the modern world is on pace to become an infertile one. How and why could this happen? What is hijacking our fertility and our health? Count Down unpacks these ques

Like Henry Ford, Sam Walton, or Steve Jobs in the early years of Ford, Walmart, and Apple, Jeff Bezos is the business story of the decade. Bezos, the richest man on the planet, has built one of the mo

The tragic and fascinating history of the first epic struggle between white settlers and Native Americans in the early seventeenth century: “a riveting historical validation of emancipatory impu

From Harold Bloom, one of the greatest Shakespeare scholars of our time comes “a timely reminder of the power and possibility of words [and] the last love letter to the shaping spirit of Bloom&r

With an epilogue on recent Russian spying, a “page-turner of a memoir” (Publishers Weekly) about an American civilian with a dream, who worked as a double agent with the FBI in the early 2

The debut novel from award-winning author Lori Ostlund—“smart, resonant, and imbued with beauty” (Publishers Weekly) that “provides considerable pleasure and emotional power” (TheNew York Times Book R

Fresh from his recent acclaim as a Good Morning America Bookclub choice, Philip R. Craig casts his observant eye on the fine line between tragedy and comedy on Martha's Vineyard.Just look at the Viney

ONE OF THE ECONOMIST'S BEST BOOKS OF THE YEAR AND A WINNER OF THE WASHINGTON MONTHLY'S ANNUAL POLITICAL BOOK AWARDPolitical experts John B. Judis and Ruy Teixeira convincingly use hard data -- demogr

Set at a boys' school in New England during the early years of World War II, A Separate Peace is a harrowing and luminous parable of the dark side of adolescence. Gene is a lonely, introverted intell

Until that fateful moment when she was shot and left for dead, Regina Harris was living la vida loca with pimps and hustlers and using whatever money she had to get high and forget that she was livin

It is Ireland in the early 1990s. Helen, her mother, Lily, and her grandmother, Dora have come together to tend to Helen's brother, Declan, who is dying of AIDS. With Declan's two friends, the six of

This lyrical debut novel is at once a passionate coming-of-age story, a meditation on illness and death, and a kaleidoscopic journey through one woman's lifetold in part by the malevolent voice of her disease.Lia, her husband Harry, and their beloved daughter, Iris, are a precisely balanced family of three. With Iris struggling to navigate the social tightrope of early adolescence, their tender home is a much-needed refuge. But when a sudden diagnosis threatens to derail each of their lives, the secrets of Lia's past come rushing into the present, and the world around them begins to transform. Deftly guided through time, we discover the people who shaped Lia's youth; from her deeply religious mother to her troubled first love. In turn, each will take their place in the shifting landscape of Lia's body; at the center of which dances a gleeful narrator, learning her life from the inside, growing more emboldened by the day. Pivoting between the domestic and the epic, the comic and the hea

During the early years of her career, while struggling to "keep body and soul apart" (as she ruefully put it later), Dorothy Parker wrote more than three hundred poems and verses for a variety of pop

In the trenches of a typical day, every parent encounters a child afflicted with ingratitude and entitlement. In a world where material abundance abounds, parents want so badly to raise self-discipli

To a small child, the world is an exciting but sometimes frightening and unstable place. In The Magic Years, Selma Fraiberg takes the reader into the mind of the child, showing how he confronts the w

Here, in his own words, are the fascinating first thirty years in the life of one of the most provocative and compelling leaders of the twentieth centuryWinston ChurchillAs a visionary, statesman, an

“Hoffman certainly knows how to enchant” (The New York Times Book Review) in this breathtaking conclusion to the Practical Magic series―a spellbinding and bewitching novel that asks how far will you go to change your fate?For over three-hundred years a curse has kept the Owens family from love―but all of that is about to change. The novel begins in a library, the best place for a story to be conjured, when beloved aunt Jet Owens hears the deathwatch beetle and knows she has only seven days to live. Jet is not the only one in danger―the curse is already at work.A frantic attempt to save a young man’s life spurs three generations of the Owens women, and one long-lost brother, to use their unusual gifts to break the curse as they travel from Paris to London to the English countryside where their ancestor Maria Owens first practiced the Unnamed Art. The younger generation discovers secrets that have been hidden from them in matters of both magic and love by Sally, their fiercely protective

A New York Times bestseller, this extraordinary memoir from Huma Abedin―Hillary Clinton’s famously private top aide and longtime advisor―offers “a gripping testament to the power of a woman finding her voice, owning her ambition, and sharing her truth” (Glennon Doyle).Abedin’s stunning memoir garnered an extraordinary amount of media coverage, with appearances on CBS Sunday Morning, the Today show, The Late Show with Stephen Colbert, The View, Late Night with Seth Meyers, Christiane Amanpour, and coverage in many other outlets, including The Washington Post, The New York Times, and NPR.The daughter of Indian and Pakistani intellectuals and advocates, Abedin grew up in the United States and Saudi Arabia and traveled widely. Both/And grapples with family, legacy, identity, faith, marriage, motherhood―and work―with wisdom, sophistication, grace, and clarity.Abedin launched full steam into a college internship in the office of the First Lady in 1996, never imagining that her work at the Wh

A New York Times Notable Book, Critic’s Top Pick, and Top Ten Book of Historical FictionNamed a Best Book of the Year by The Washington Post, NPR, Vogue, The Wall Street Journal, and Bloomberg Businessweek​From one of today’s most brilliant and beloved novelists, a dazzling, epic family saga set across a half-century spanning World War I, the rise of Hitler, World War II, and the Cold War that is “a feat of literary sorcery in its own right” (Oprah Daily).The Magician opens in a provincial German city at the turn of the twentieth century, where the boy, Thomas Mann, grows up with a conservative father, bound by propriety, and a Brazilian mother, alluring and unpredictable. Young Mann hides his artistic aspirations from his father and his homosexual desires from everyone. He is infatuated with one of the richest, most cultured Jewish families in Munich, and marries the daughter Katia. They have six children. On a holiday in Italy, he longs for a boy he sees on a beach and writes the sto

From a brilliant Brookings Institute writer, a vivid, timely, and insightful examination of the critical role that oceans currently play in the struggle for global power, in the bestselling tradition

Named a Best Book of the Year by The New York Times Nominated for the 2021 Edgar Allan Poe Award From a Pulitzer Prizewinning investigative reporter at the Charleston Gazette-Mail, a ';powerful,' (The

In the tradition of Barbara Ehrenreich’s classic Nickel and Dimed, a talented young journalist goes undercover as a casino labor-union organizer in this rare inside look at the ongoing struggle of hou

In the tradition of In Cold Blood and The Executioner’s Song, this haunting, insightful, and surprisingly intimate portrait of Saddam Hussein provides “a brief, but powerful, meditation on

Set in the fictional town of Castle Rock, MaineFrom #1 New York Times bestselling author Stephen King, a powerful tale of grief, of love's enduring bonds, and the haunting secrets of the past.Set in t

In this “riveting read, meshing memoir with scientific explication” (Nature), a world-renowned neuroscientist reveals how he learned to communicate with patients in vegetative or “gr

The New York Times bestselling author of In Harm’s Way and Horse Soldiers shares the powerful account of an American army platoon fighting for survival during the Vietnam War in “an import

When bombs explode at the Islamic Cooperation Council’s headquarters in Oslo, detective Hanne Wilhelmsen is on the case in the ninth installment of the award-winning series from Norway’s bestselling c