Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Learning to fly at the Unicornia Academy of Magic. A glittery birthday celebration at a magical theme park. A magical baking competition full of sugar and surprises. Practising a dance routine on a sparkling rainbow stage. All of it taking place in a land where unicorns are everywhere! For beginning chapter-book readers who adore a certain mythical beast, this delightful boxed set of four paperback stories is guaranteed to make an enchanting gift.Includes:Unicornia: Learning to FlyUnicornia: A Magical BirthdayUnicornia: The Cupcake ContestUnicornia: The Dance Show

Learn all about fantastic frogs in this new Maisy’s Planet book, with a fun open-out finale!Hop along with Maisy as she finds out about fantastic frogs (and terrific toads too)! Discover their incredible life cycles and how they change from tiny tadpoles to fully grown frogs. Learn what they need, the places they live and the amazing sounds they make (ribbit, ribbit!). Open out the final scene to go pond dipping with Maisy!Maisy’s Planet books are perfect for little nature-lovers aged from 18 months.Each sturdy, toddler-friendly board book celebrates a different feature of the natural world with bright colours, simple language and a fun open-out spread. Love our planet with Maisy!

Learn all about ladybirds in this new Maisy's Planet book, with a fun open-out finale!Join Maisy as she gets to know lovely ladybirds! This cheerful board book introduces little ones to everyone's favourite insect and gives practical ideas about what you can do to help the ladybirds in your garden or local park. Open out the final scene to go ladybird-spotting with Maisy and friends! Maisy's Planet books are perfect for little nature-lovers aged from 18 months. Each sturdy, toddler-friendly board book celebrates a different feature of the natural world with bright colours, simple language and a fun, final open-out spread.Love our planet with Maisy!

Who doesn’t love a butterfly? Set a little one’s heart aflutter with this exploration of the beautiful creatures, led by everyone’s favorite mouse.Join Maisy as she learns all about gorgeous butterflies! This fifth book in the Maisy’s Planet series introduces children to both butterflies and moths, as it investigates everything from caterpillars to cocoons to the insects in flight. Find out about patterns, color, and camouflage, and open out the final scene to marvel at Maisy’s butterfly- and moth-friendly garden!

Learn all about water with Maisy in this new series celebrating our planet!Maisy is finding out about water – from what comes out of her tap, to rain, rivers and all the way to the sea! Why do we need water? Where does it come from? Join Maisy to find the answers to these questions and many more in this colourful board book. Open out the final scene to dive beneath the waves with Maisy!Maisy’s Planet books are perfect for little nature-lovers aged from 18 months. Each sturdy, toddler-friendly board book celebrates a different feature of the natural world with bright colours, simple language and a fun open-out spread.Love our planet with Maisy!

Learn all about beautiful birds in the latest addition to the Maisy's Planet series!Discover the world of birds with Maisy! This bright and cheerful board book introduces little ones to our feathered friends, from starlings, ducks and robins to soaring seabirds and swooping birds of prey – and even birds that don't fly. Follow Maisy as she finds out what birds need, how they build their nests, where they live, and how we can help them. Open out the final scene to join Maisy and her friends bird-watching!Maisy's Planet books are perfect for little nature-lovers aged from 18 months. Each sturdy, toddler-friendly board book celebrates a different feature of the natural world with bright colours, simple language and a fun, final open-out spread.Love our planet with Maisy!

Explore the world of trees with Maisy in this brand-new series celebrating our planet!Maisy is learning all about different kinds of trees. What is a tree and how does it grow? How do leaves vary? How do trees change through the year and why don’t some trees change at all? Little ones will discover the answers to these questions and many more in this colourful board book. Open out the final scene and wonder at amazing trees from around the world!Maisy’s Planet books are perfect for little nature-lovers aged from 18 months. Each sturdy, toddler-friendly board book celebrates a different feature of the natural world with bright colours, simple language and a fun open-out final spread.Love our planet with Maisy!

James and Cordelia must save London — and their marriage — in this thrilling and highly anticipated conclusion to The Last Hours series from the #1 New York Times and USA TODAY bestselling author Cassandra Clare. Chain of Thorns is a Shadowhunters novel.Cordelia Carstairs has lost everything that matters to her.In only a few short weeks, she has seen her father murdered, her plans to become parabatai with her best friend, Lucie, destroyed, and her marriage to James Herondale crumble before her eyes. Even worse, she is now bound to an ancient demon, Lilith, stripping her of her power as a Shadowhunter.After fleeing to Paris with Matthew Fairchild, Cordelia hopes to forget her sorrows in the city’s glittering nightlife. But reality intrudes when shocking news comes from home: Tatiana Blackthorn has escaped the Adamant Citadel, and London is under new threat by the Prince of Hell, Belial.Cordelia returns to a London riven by chaos and dissent. The long-kept secret that Belial is James and

A Maisy First Experiences story, celebrating the wonders of nature and exploring the outdoors. Join Maisy and her friends on an adventure as they look out for birds, bees, minibeasts and more! Now available in paperback.Maisy and her friends are heading to their local park for a nature walk! Join in on this adventure as they have fun looking out for birds, bees, minibeasts and more! There is so much to do: a visit to the pond, a spot of birdwatching, a wander through the wildflower garden and even building a den!The perfect book for little ones who love the outdoors.

故事的主角，是一隻頑皮的鴿子，在Don't Let the Pigeon Drive the Bus (別讓鴿子開巴士)中，一心夢想自己能開公車的鴿子，千方百計，苦苦哀求，希望能開公車。從畫面的安排與對話，滿滿的互動元素，若與小孩一起共讀，邊讀邊演，想必非常有趣。而在The Pigeon Needs a Bath! (鴿子需要洗澡)中，鴿子就是不愛洗澡的小朋友的化身，各種耍賴的招數，最後鴿子卻愛上洗澡，家長應該更想知道莫威樂是怎麼說服鴿子的吧！美國的出版社今年更推出這本書的洗澡書，讓閱讀延伸至浴室！本套書共有以下七本平裝書1. Don't Let the Pigeon Drive the Bus! 9781844285136When the driver leaves the bus temporarily, he gives the reader just one instruction: "Don't let the pigeon drive the bus!" But, boy, that pigeon tries every trick in the book to get in that driving seat: he whines, wheedles, fibs and flatters. Will you let him drive? Told entirely in speech bubbles, this is a brilliantly original book.2. Don't Let the Pigeon Stay Up Late! 9781406308129It's getting late and the bus driver is going to brush his teeth and get ready for bed. Will you do him a favour while he is gone – don't let the pigeon stay up late! But this pigeon is wide awake: he isn't even tired – in fact he's in the mood for a hot-dog party! So will YOU let him sta

Maisy is fixing Cyril's car, and she needs your help! With easy-to-use pull, slide and play tabs on every spread, little ones will love this interactive garage experience. Uh oh - Cyril's car has broken down! Luckily Maisy and her friends know just what to do. Pull, slide and play with the tabs to jack up the car, lower in a new engine, check the lights and wipers, and finally drive out of the garage.A delightful story about teamwork with exciting, interactive spreads, ideal for imaginative play!

David Wiesner Picture Books Collection (5 本平裝本)9781849394475 Tuesday (Winner of the Caldecott Medal)The unpredictable events of a particular Tuesday unroll before the reader with the precision and clarity of a silent movie . . . In this ingenious and imaginative – nearly wordless – picture book, frogs in a pond lift off on their lily pads and fly to a nearby town where they zoom through a woman’s living room, encounter a dog playing in his yard, and distract a bathrobe-clad citizen from his midnight snack. Who knows what will happen next Tuesday?9781849394499 Flotsam (Winner of the Caldecott Medal) A bright, science-minded boy goes to the beach equipped to collect and examine flotsam-anything floating that has been washed ashore. Bottles, lost toys, small objects of every description are among his usual finds. But there’s no way he could have prepared for one particular discovery: a barnacle-encrusted underwater camera, with its own secrets to share . . . and to keep.9781783

Meet monsters from around the world in this stunning pop-up book. From Owen Davey, the award-winning illustrator of My First Pop-Up Dinosaurs, comes a second striking pop-up treasury. Discover a world

A fun lift-the-flap introduction to first concepts from Ingela P Arrhenius. Lift the flaps in this engaging introduction to colours, numbers, shapes, opposites and the body for the very youngest reade

這是一本關於城市、孩子與思念的繪本。故事從一名小孩對「你」說話開始，引導讀者一步步感受到城市的冷與大，也感受到孩子心中的柔軟與堅定。Sydney Smith 以細膩構圖與簡潔語言，鋪陳一段未說明對象的尋找，直到最後才悄悄揭示思念的真相。畫面詩意，情感深刻，是一本值得反覆閱讀與細看的作品。It can be a little scary to be small in a big city, but this child has some good advice for a very special friend in need.Winner of the Ezra Jack Keats AwardA New York Times/New York Public Library Best Illustrated Book of the YearWinner of the CILIP Kate Greenaway MedalIt can be a little scary to be small in a big city, but it helps to know you're not alone.When you're small in the city, people don't see you, and loud sounds can scare you, and knowing what to do is sometimes hard. But this little kid knows what it's like, and knows the neighborhood. And a little friendly advice can go a long way.Alleys can be good shortcuts, but some are too dark.Or, there are lots of good hiding places in the city, like under a mulberry bush or up a walnut tree.And, if the city gets to be too much, you're always welcome home, where it's safe and quiet.Award-w

A magical story about finding your identity from one of the most acclaimed storytellers of his generation, richly illustrated in full colour by an internationally renowned artist.My mother says that all things can be turned to tales. I thought she meant tales like fish tails, but I was wrong. She meant tales like this, tales that are stories. But this tale of mine is very like a fish tail too...Annie has never been like the other girls. Her mam tried sending her to school when she was small, but Annie couldn’t seem to make words or numbers stick. She prefers instead to be swimming in the sea, or sunbathing on the shore at Stupor Beach, her head full of tales. She should have been a fish, her mam always tells her, and Annie knows the truth of it. Then a stranger who comes to town is struck by the beauty and the wonder of her, and Annie Lumsden realizes that perhaps she really is half a creature from the sea.

Everyone's favourite princess returns for her smelliest battle yet. A foul cloud is plaguing the goat pasture, but every time the Princess in Black and her friend the Goat Avenger manage to get rid of

From the creators of the award-winning When's My Birthday? comes an inspirational book that will comfort and support through any challenge.just in case you want to flyhere's some wind and here's the s

From the dynamic, dream team of Jon Klassen and Mac Barnett comes the final instalment in the hilarious shape trilogy."Simple shapes and succinct story express big ideas. Makes us consider fear of str

Maisy is throwing a Christmas party, and all her friends are invited. Open the envelopes to join in the festive fun with cards, an advent calendar, a gingerbread recipe and more! Maisy is throwing a Christmas party! When her friends R.S.V.P., they send other Christmas surprises including an advent calendar, decorations, a gingerbread recipe and more. Happy Christmas, everyone! This story includes six real envelopes containing Christmas cards, gifts, decorations and a special letter from Maisy to personalise.

1. Maisy's NurseryIt’s time for school! Maisy and her friends play with building blocks, practice their counting, and sit down for storytime. A pop-up classroom scene waits at the end of the book with paper press-outs of Maisy and her pals. Kids will relish the chance to play teacher and decide the lessons, all the while putting their imaginations to the test and learning about the routines that make up a day at school.2. Maisy's FarmWhat’s more fun than a day on the farm? A day on the farm with Maisy! Maisy’s Farm is an amazing three-dimensional pop-up farm full of things to do and animals to love. The sturdy stand-up Maisy figure has arms that move and a tractor to ride in. Children will love to help Maisy milk the cow, collect the eggs, tend to the vegetable patch, and more! With twenty-six full-color press-out pieces and loads of flaps to lift and tabs to pull, there’s no end to the fun on Maisy’s farm.3. Maisy's HouseMaisy’s fans are invited to join the friendly mouse as she goes

The complete Chaos Walking trilogy is now available in this striking boxed set. Soon to be a major motion picture starting Tom Holland and Daisy Ridley - read it before you watch the film!Prentisstown isn’t like other towns. Everyone can hear everyone else’s thoughts in a constant, overwhelming Noise.There is no privacy. There are no secrets. Then Todd Hewitt unexpectedly stumbles on a spot of complete silence.Which is impossible. And now he’s going to have to run… Patrick Ness’s award-winning modern classic makes essential, gripping reading and is soon to be a major motion picture starring Tom Holland and Daisy Ridley. This boxed set includes paperback editions of The Knife of Never Letting Go, The Ask and the Answer and Monsters of Men.

An action-packed storytelling adventure that flips the traditional fairy tale on its head.When it’s time for Jamie’s bedtime story, his dad begins to tell an age-old fairy tale about a prince in a far

A billy can't be posted, delivered on a bike, or sent in a car, truck or train. It has to be loaded on a ship with all those other Anzac billies for other soldier dads...During World War I, Australian

Sainsbury's Children's Book Awards 2019This terrific, travel-sized Where's Wally? book is full of searches, games and creative activities. Solve perplexing puzzles, personalise your travel checklist, design your own time machine and more. Plus, keep track of your own journeys with fun prompts, facts and challenges. And don’t forget to search for Wally – he's hiding in every scene! This search-and-find book also comes with a bonus sensational story card game!Fourth in a series of travel-sized Wally titles – look out for The Totally Essential Travel Collection, The Colouring Collection and Games on the Go! on your adventures!

Cat has no idea what he wants to eat ... until it’s right in front of him, that is. From the acclaimed creator of Everyone comes a book for picky eaters – and the patient souls that feed them! Cat is

The heart-warming story of a little boy who misses his mum from award-winning author–illustrator Simon James. The day that Stanley’s mum had to go away, he decided to go to Mars. In his place, a not-v

本套 Listen and Join In CD Collection 精選十個經典幼兒故事，由知名配音演員如 Brian Blessed、Imelda Staunton 等人生動演繹，總長超過六小時。從 Guess How Much I Love You、We’re Going on a Bear Hunt 到 Owl Babies，每一則故事都伴隨節奏與互動，引導孩子在聆聽中跟唱、律動、想像。這套合集以堅固外盒收納十片有聲 CD，無論在家、車上或派對時光，都能隨時陪伴孩子沉浸故事的樂趣。音色溫暖，語調鮮明，是初學英語與啟發聽覺想像的理想入門選擇。亮點：收錄十部經典幼兒繪本故事超過六小時的互動有聲內容名演員溫柔演繹，聲情並茂適合家庭共聽與英語啟蒙Young children aged 2 and above will love listening to their favourite stories as they dance and sing along with the Listen and Join In CD Collection. Featuring over six hours of classic children's stories and activities that little ones can join in with in the car, at home or at a birthday party, their favourite characters can be enjoyed anywhere, anytime! With classic stories including Michael Rosen's wonderful We're Going on a Bear Hunt, Martin Waddell's charming Owl Babies and much, much more - and read aloud by lively characters such as the brilliant Brian Blessed and Imelda Staunton - this slipcase collection of 10 audio CDs is a great addition to any child'

Little Beaver s search for a friend he thinks he hears across a pond is perfect for every child who's ever felt lonely. "Children old enough to long for friends of their own will nestle right into this appealing story....Ideal for reading aloud at the beginning of the school year of during camp sessions, when there's a little bit of Little Beaver in every kid." -- Booklist "Perfect for little ones at quiet-time or bedtime." -- Publishers Weekly "Enchanting." -- The New York Times Book Review商品除瑕疵品外，恕不接受退換貨因拍攝略有色差，圖片僅供參考，顏色請以實際收到商品為準

A picture book favourite, this is the dramatic and moving Cornish tale of a cat and a fisherman who brave the stormy seas to save their village.This is the stunningly illustrated story of the seaside village of Mousehole Cornwall, where Mowzer the cat lives happily with old fisherman Tom – Tom who rocks the rocking chair just right, and catches fresh fish for dinner every night. Their life is a happy one – until one terrible winter, the Great Storm-Cat comes clawing and snarling and leaping at the harbour walls, so that no boat can go out to sea to fish. Soon, with Christmas coming, there is no food left in Mousehole. It is then that Mowzer and Tom set out to brave the fury of the waves together, and discover that it might just need a cat’s perspective to understand – and tame – the ferocious ways of the Great Storm-Cat sea… Gently yet powerfully told, this incredibly moving story of bravery, sacrifice and companionship inspired by Cornish legend is sure to connect with readers of all

Bear had never had a real Christmas... Clearly, the most important thing was pickles. Get ready for Christmas and the best kind of surprises as grumpy Bear and eager Mouse return in a funny tale full

What happens when a boy is brave enough to stand up for what he feels is right?Greedy Greenbackboy's got an idea for a game. He wants Snowboy to help him cut down all the trees in the forest and catch

"I don't like the dark," said Little Bear. "What dark?" said Big Bear. "The dark all around us," said Little Bear.In this tender account of a sleepless night in the bear cave, Big Bear sets out with all his patience and understanding to show Little Bear that the dark is nothing to be afraid of. When all the lanterns in the cave aren't enough to quell Little Bear's troubled emotions, Big Bear offers—in a final loving gesture—nothing less than the bright yellow moon and the twinkling stars! More comforting than even the best of lullabies, this bedtime story is destined to become a classic.商品除瑕疵品外，恕不接受退換貨因拍攝略有色差，圖片僅供參考，顏色請以實際收到商品為準

Celebrate 25 years of Big Bear, Little Bear and their cosy cave in this gorgeous anniversary edition of a classic bedtime favourite.Described as 'the most perfect children's book ever written', this i

Come along on a bear hunt in this award-winning classic from Michael Rosen and Helen Oxenbury.We’re going on a bear hunt. We’re going to catch a big one.Will you come too? For more than twenty-five ye

Little Chicken has learnt what every good story should have ... an ELEPHANT of surprise! SURPRISE! The little red chicken is back in David Ezra Stein’s follow-up to the Caldecott Honor Book Interrupti

A fiery story about friendship and asking for help from award-winning author-illustrator Emma Yarlett.One day Alex finds a dragon living in the cupboard under the stairs. Luckily he knows just what to

The multiple award-winning and bestselling Jon Klassen presents the final tale in his acclaimed and bestselling hat trilogy, giving his deadpan finale a surprising new twist... Hold on to your hats! F

A colourful first pop-up book of things that go, perfect for tiny hands.Things that fly, things that zoom and things that float - find all the things that go in this colourful pop-up book. With 15 pop

"Picture book lovers will find much to like in Triangle" GuardianFrom the award-winning team behind Sam and Dave Dig a Hole, and illustrated by Jon Klassen, the Kate Greenaway-winning creator of This