Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

The important thing about being One is that life has just begun. Look inside and discover all the important things about being Six, Five, Four, Three, One, Two, and YOU, in this lively picture book

★ 解開人類DNA密碼，理解「我們是誰」的關鍵之書★ 從23對染色體出發，一場橫跨生命史的科學旅程★ 結合科學 × 歷史 × 哲學，最引人入勝的基因故事★ 百萬暢銷科普經典，帶你看見未來醫學的輪廓本書以23對染色體為主軸，透過基因故事串聯人類演化、疾病、行為與未來醫學，呈現基因科學的全貌。作者以生動敘事解釋複雜概念，同時探討基因技術帶來的倫理與哲學議題。內容兼具知識深度與可讀性，是理解基因與人類本質的重要科普經典。"Ridley leaps from chromosome to chromosome in a handy summation of our ever increasing understanding of the roles that genes play in disease, behavior, sexual differences, and even intelligence. . . . . He addresses not only the ethical quandaries faced by contemporary scientists but the reductionist danger in equating inheritability with inevitability." —The New YorkerThe genome's been mapped. But what does it mean?Matt Ridley’sGenomeis the book that explains it all: what it is, how it works, and what it portends for the futureArguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome—our complete set of DNA—raises almost as many questions as it answers. Questions that will profoundly

This monograph chronicles the life of an eminent pioneer of surgery, K.H. Digby, the important milestones in his professional life and the hardship he faced to fulfill his dreams.Digby was a remarkabl

While being engaged in fun activities, your children will be practicing important age-appropriate skills such as visual discrimination, sequencing, small muscle coordination, following directions, rea

While being engaged in fun activities, your children will be practicing important age-appropriate skills such as visual discrimination, sequencing, small muscle coordination, following directions, rea

This touching story about a young boy coping with his grandfather's disability has long been one of Tomie dePaola's most popular picture books. Now, for the first time, it is available in a larger fo

This volume gives language teachers, software designers, and researchers who wish to use technology in second or foreign language education the information they need to absorb what has been achieved so far and to make sense of it. It is designed to enable the kind of critical reading of a substantial literature that leads to a balanced and detailed knowledge of the field. Chapter by chapter, the book builds, through description, analysis, examples, and discussion, a detailed picture of modern CALL.In this book, the label “CALL” is interpreted broadly to include technology-enhanced language learning, Web-enhanced language learning, and information and communication technologies for language learning. The work is distinguished by its attention to a range of languages rather than just English.The authors first set the scene and introduce major areas of interest and growth in CALL, and then look in depth at seven important dimensions: design, evaluation, computer-mediated communication, th

《Confessio Amantis（戀人的告白）》是十四世紀英國詩人 John Gower 的代表作之一，也是中世紀英語文學的重要經典。本書為三卷本學術版的第一卷，收錄〈序言〉以及第一與第八書，實際上構成全詩的道德與結構核心。作品以一名戀人向愛神維納斯的神父 Genius 懺悔為敘事框架，透過寓言式對話，探討愛情、道德、權力與社會秩序之間的關係。詩中大量引入古典神話、聖經故事與歷史寓例，討論傲慢、虛偽、放縱、婚姻與君權等議題，既反映中世紀晚期的倫理觀，也回應當時英格蘭的政治與社會現實。本版完整收錄中英雙語文本，保留拉丁段落並附現代英語翻譯，並提供詳盡註解、詞彙說明與研究書目，方便研讀與教學。本書適合中世紀文學、英語史、思想史與文化研究領域的學生與研究者，是深入理解 Gower 詩學與中世紀道德想像的重要基礎讀本。English poet Gower (1325-1408) released his fictional confession, rooted in old texts, in 1390-92. This edition presents it in three volumes, this first devoted to the frame: the Prologue, Book One and Book Eight. Extensive marginal glosses and explanatory endnotes are included. The format has been changed for the second edition to make it easier for readers to find their way around. The second volume covers Books 2-4, and the third Books 5-7. Annotation c2006 Book News, Inc., Portland, OR (booknews.com)

Sometimes life just doesn’t seem fair. Have you ever had a day when . . . your favorite pants shrunk in the wash? your best friend was being a beast? you were too short to go on the best ride?

Dear Friends, In most fish families, after the mother has laid the eggs and the father has fertilized them, the eggs are left on their own. But there are exceptions, such as the seahorse, stickleback, tilapia, Kurtus nurseryfish, pipefish, bullhead catfish and some others. Not only are the eggs cared for by a parent but – surprise – that parent is the father. This may sound strange but it is the truth. And this is my story about them. I hope you enjoy my story.

Forget everything you've read about the age of dumbed-down, instant-gratification culture. In this provocative, intelligent, and convincing endorsement of today's mass entertainment, national bestselling author Steven Johnson argues that the pop culture we soak in every day-from The Lord of the Rings to Grand Theft Auto to The Simpsons-has been growing more and more sophisticated and, far from rotting our brains, is actually posing new cognitive challenges that are making our minds measurably sharper. You will never regard the glow of the video game or television screen the same way again.

Let the overseas snogfest begin! Georgia and Jas are off to Hamburger-a-gogo land! Georgia plans to track down Masimo, the Italian-American dreamboat, but after a long week in America, she only suc

What is sand? How is it formed? Where does sand come from? How does it get to the beach? Why is it different colors? Let the sandpiper sleuth show you the answers to these questions in this lively, co

Amazing Gorillas! is the third paperback title in an exciting series of non–fiction I Can Read Books that features kids' favorite animals and spectacular photographs from the Wildlife Conser

She wished something would happen. Something good. To her. Looking at the bright, fuzzy picture in the magazine, she thought, Something like that. Checking her wish for loopholes, she found one. Ho

Three new and original stories about Cordelia, Florinda and Ella and the delightful world of dolls. Beautifully illustrated throughout with colourful and appealing illustrations. Part of Young Reading Series 1 for children just starting to read alone.Developed in conjunction with reading experts from Roehampton University.

Bob Books Set 1: Beginning ReadersTeach a child letter sounds with Bob Books Set 1! With four letters in the first story, children can read a whole book. Consistent new sounds are added gradually, unt

The HMMWV, better known as the Humvee or Hummer, has set the world standard for army tactical vehicles since its introduction into the US Army in the 1980s. Designed to be the successor to the jeep of

Angie Cruz has established herself as a dazzling new voice in Latin American fiction, her writing compared to Gabriel García Márquez's by The Boston Globe. Now, with humor, passion, and int

Graduation day is here! But a special guest almost ruins the event. Luckily, Mrs. Connor's class uses all the skills they have learned in the first grade to save the day!

Runny Babbit lent to wunch And heard the saitress way, "We have some lovely stabbit rew -- Our Special for today." From the legendary creator of Where the Sidewalk Ends, A Light in the Attic, Falling

When you are afraidI will take your handand not let go--In this delightful and lyrical text by renowned children's author Eileen Spinelli, a young girl finds reassurance from all of her family members

Sammy’s never been what you might call lucky. But finding a dead cat on her birthday? That ranks up there in her top-10 unluckiest moments. And not just because it was the ugliest dead thing she’d eve

Geza Ottlik had a remarkable talent for discovering and analyzing strange and fascinating aspects of card play in bridge. This brilliant book is the result of his collaboration with Hugh Kelsey—whose skill at high-level analysis of bridge problems was equalled only by his ability as an instructive writer. Adventures in Card Play is universally regarded as one of the all-time great classics of bridge.

After their parents are lost in an accident, thirteen-year old twins Grace and Marty are whisked away to live with their Uncle Wolfe-an uncle that they didn't even know they had! The intimidating Uncl

In a changing employment climate and with the growth of demand for careers guidance at all stages of life, careers guidance practice has moved from its positivist world view, with the counsellor as ex

Hola! Bonjour! Ciao! The beauty of multiple languages and ethnic music is presented in this incredible collection of children’s songs from around the world. Children and adults from various countri

STAEDTLER─Made in Germany 施德樓─對品質的堅持座落於Nuremberg 的企業總部，我們很驕傲的說，我們仍堅持在德國製造，那種對品質堅守承諾的傳統。相較於全世界各大品牌，紛紛以成本考量，寧願犧牲品質的現實考量，作為德國紐倫堡施德樓基金會的公司─"Made in Germany"是一種象徵著品質的使命與榮耀，我們有75％的產品，仍堅持著由這裡生產來發送全世界。施德樓 防乾白

STAEDTLER─Made in Germany 施德樓─對品質的堅持座落於Nuremberg 的企業總部，我們很驕傲的說，我們仍堅持在德國製造，那種對品質堅守承諾的傳統。相較於全世界各大品牌，紛紛以成本考量，寧願犧牲品質的現實考量，作為德國紐倫堡施德樓基金會的公司─"Made in Germany"是一種象徵著品質的使命與榮耀，我們有75％的產品，仍堅持著由這裡生產來發送全世界。施德樓 防乾白

This is the first modern calculus book to be organized axiomatically and to survey the subject's applicability to science and engineering. A challenging exposition of calculus in the European style, i

Why is Bernard the Bear baffled? Well, for one thing, he has lost his whistle and he can't figure out where it is. For another thing, he has just met Jack Jones–one of the High–Rise Private Eyes and a very fine detective in his own right–and Jack won't stop talking about . . . pretzels! Luckily for the baffled bear (and for kids who are ready to read on their own), Jack takes the mystery (and the bear) back to the high–rise to meet Bunny Brown. Bunny is the brains of the operation, and she quickly determines that it's high time for the High–Rise Private Eyes to open case file #7: The Case of the Baffled Bear.

Fly Guy loves the school lunchroom. He loves the dirty dishes, the smelly mop, and the garbage cans. But when the lunch ladies discover there's a fly in the cafeteria, chaos ensues! Though Fly Guy mak

Johanna Spyri’s Heidi is beautifully retold, following the exploits of the orphaned girl sent to live in the Alps with her grumpy grandfather. Clear, engaging text, accompanied by stunning origina

A New Translation From The French By Marion Wiesel Night is Elie Wiesel masterpiece, a candid, horrific, and deeply poignant autobiographical account of his survival as a teenager in the Nazi death

Covers everything you are likely to need – 15,000 encyclopaedic entries covering people, places, history, geography, the arts and popular culture Get in-depth understanding on topics such as festi

Description風靡全球的迪士尼卡通人物要陪你一起學英語囉！English Land is a six-level course for children learning English in primary school. It uses a range of classroom strategies and materials proven to be effective with y

An abandoned Southwark warehouse burns next door to a women's shelter for victims of spousal abuse. Within it lies the charred corpse of a female body burned beyond all recognition. At the same time, workers at Guy's Hospital anxiously discuss the disappearance of a hospital administrator -- a beautiful, emotionally fragile young woman who's vanished without a trace. And in an old, dark, rambling London house, nine-year-oldHarriet's awful fears won't be silenced -- as she worries about her feuding parents, her schoolwork . . . and the strange woman who is her only companion in this scary, unfamiliar place. Gemma James and Duncan Kincaid -- lovers and former partners -- have their own pressing concerns. But they must put aside private matters to investigate these disturbing cases. Yet neither Gemma nor Duncan realize how closely the cases are connected -- or how important their resolutions will be for an abducted young child who is frightened, alone . . . and in serious peril.

The Powerful Newbery Award-winning classicA landmark in children's literature, winner of the 1970 Newbery Medal, and the basis of an acclaimed film, Sounder traces the keen sorrow and the abiding fait

After 12 years, spanning two county governors and five culture center directors, teh Taipei County Yingge Ceramics Museum, the first one of its kind in Taiwan, was finally opened to the public on Nove

A captivating retelling of Anna Sewell’s classic novel beautifully illustrated by Alan Marks.Perfect for encouraging independent reading.Part of Young Reading Series 2 for readers growing in confidenc