Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Bring the mysterious and magical world of Emily Dickinson into your home by making the comforting foods that Emily loved to cook. Whether you are a fan of the hit television series Dickinson or have long been inspired by Emily Dickinson's poems, this enchanting cookbook brings Emily to life as little else could. A distinguished food historian said this about Emily: "She was probably better known as a baker than a poet in her lifetime." Remarkably, that is true! Emily wrote her poetry in the kitchen of her home in Massachusetts and was cooking up a storm much of the time. She wrote poems on the wrappers of packages of chocolate that she had ordered for baking; and she wrote recipes in her notebooks of poems. Food and cooking were central to Emily's identity and were woven into her vocation of writing poetry. The more than 50 recipes in this colorful and lavishly illustrated book include recipes that Emily recorded during her life, other recipes we know she and her family enjoyed, and re

當老師雪麗爾小姐調皮地為她學生的父母設計一個測試IQ難題時，她的學生很高興地發現她的父母能夠迅速解決這個問題。但是，他們是怎麼做到的呢？讓我們一起來找出答案！《我是數學明星！》系列作者群是由新加坡過立教育學院(NIE)教授們所組成，系列書以故事形式呈現具有挑戰性的數學難題，透過引人入勝的故事情節，並使用各種數學啟發式教學技巧，逐步描述並帶領讀者解決難題，這些教學技巧也是新加坡知名的數學教學的一部分。透過插圖和有趣的故事情節，小讀者將在學習數學的路上受到啟發，提升理解力、學習數學表示和解決有趣的數學問題！本書附有知名數學教師Yeap Ban Har 博士所提供的課後習題與解答。When Miss Cheryl the teacher cheekily sets an IQ puzzle for her student's parents, her student is delighted to find that her parents are able to solve it quickly. But, how did they do it? Let's find out!The I'm a Maths Star! series comprises challenging Maths puzzles, presented in story form. Puzzles are described and then solved, step-by-step, through an engaging storyline, and using various Maths heuristic techniques that are also taught as part of the world-renowned Singapore Maths curriculum. Through illustrations and an engaging storyline, children will learn Maths heuristics, and be inspired to persevere in understanding, representing, and solving fun and intriguing Maths problems!Includes a Gu

一個盯著螞蟻看的男孩突然想到一道有趣但又難的數學題。如果螞蟻不斷相互碰撞並改變方向，牠們需要多久的時間才能從棍子上掉下來？這聽起來像是一個不可能解開的謎題嗎？並非如此！讓我們一起繼續讀下去，看看男孩如何找出巧妙解決方案！《我是數學明星！》系列作者群是由新加坡過立教育學院(NIE)教授們所組成，系列書以故事形式呈現具有挑戰性的數學難題，透過引人入勝的故事情節，並使用各種數學啟發式教學技巧，逐步描述並帶領讀者解決難題，這些教學技巧也是新加坡知名的數學教學的一部分。透過插圖和有趣的故事情節，小讀者將在學習數學的路上受到啟發，提升理解力、學習數學表示和解決有趣的數學問題！本書附有知名數學教師Yeap Ban Har 博士所提供的課後習題與解答。A boy staring at ants suddenly thinks of a fun but difficult Maths problem. How long will it take the ants to fall off the stick he's looking at, if they keep bumping into each other and changing directions? Does this sound impossible to solve? It isn't! Read on to find out the boy's ingenious solution!The I'm a Maths Star! series comprises challenging Maths puzzles, presented in story form. Puzzles are described and then solved, step-by-step, through an engaging storyline, and using various Maths heuristic techniques that are also taught as part of the world renowned Singapore Maths curriculum. Through illustrations and an engaging storyline, children will learn Maths

一個富有同情心的女孩主動幫助一位陷入困境的王子！王子想要拯救被邪惡女巫詛咒的公主，而詛咒的形式是一個耐人尋味的數學謎題，最終將需要女孩和王子的智慧來解開，他們能及時做到嗎？《我是數學明星！》系列作者群是由新加坡過立教育學院(NIE)教授們所組成，系列書以故事形式呈現具有挑戰性的數學難題，透過引人入勝的故事情節，並使用各種數學啟發式教學技巧，逐步描述並帶領讀者解決難題，這些教學技巧也是新加坡知名的數學教學的一部分。透過插圖和有趣的故事情節，小讀者將在學習數學的路上受到啟發，提升理解力、學習數學表示和解決有趣的數學問題！本書附有知名數學教師Yeap Ban Har 博士所提供的課後習題與解答。A compassionate girl offers to help a prince in distress! The prince wants to save his princess who is under the curse of a wicked witch. The curse is in the form of an intriguing Maths puzzle that will end up taking the wits of both the girl and the prince to solve. Will they be able to do it in time?The I'm a Math Star! series comprises challenging Maths puzzles, presented in story form. Puzzles are described and then solved, step-by-step, through an engaging storyline, and using various Maths heuristic techniques that are also taught as part of the world-renowned Singapore Maths curriculum. Through illustrations and an engaging storyline, children will learn Maths heuristics, and be inspire

An unconventional vicar must exorcise the dark past of a remote village haunted by death and disappearances in this explosive and unsettling thriller from the acclaimed author of The Chalk Man. "Hypnotic and horrifying . . . Without doubt Tudor's best yet, The Burning Girls left me sleeping with the lights on."--Chris Whitaker, New York Times bestselling author of We Begin at the End A dark history lingers in Chapel Croft. Five hundred years ago, Protestant martyrs were betrayed--then burned. Thirty years ago, two teenage girls disappeared without a trace. And a few weeks ago, the vicar of the local parish hanged himself in the nave of the church. Reverend Jack Brooks, a single parent with a fourteen-year-old daughter and a heavy conscience, arrives in the village hoping for a fresh start. Instead, Jack finds a town rife with conspiracies and secrets, and is greeted with a strange welcome package: an exorcism kit and a note that warns, "But there is nothing covered up that will not be

Benjamin loves chocolate. He also knows a lot about it. But one person knows more - his grandfather Marco, otherwise known as the Chocolate King.Benjamin's family arrive in France at the beginning of the 17th century, having escaped the Spanish Inquisition. They have nothing but the clothes on their backs and as many cocoa beans as they can carry. Back in Spain, Benjamin's grandfather Marco was El Rey de Chocolate, famed for his delicious hot chocolate drink, a recipe he claims he learned from an intrepid Spanish explorer.But now, if the family are to make a living, they must persuade the people of France to fall in love with Marco's strange mud-coloured concoction. Benjamin is desperate to help, dreaming that he might grow up to wear the Chocolate King crown. Then, one day, Benjamin causes chaos in the kitchen.Covered head-to-toe in chocolate, he stumbles into the street and straight into the path of the real King - the King of France. Finally, the family get the breakthrough they nee

NYT Best Children's Books of 2021A young adult graphic novel about three foreign exchange students and the pleasures, and difficulties, of adjusting to living in Japan.Living in a new country is no walk in the park-Nao, Hyejung, and Tina can all attest to that. The three of them became fast friends through living together in the Himawari House in Tokyo and attending the same Japanese cram school. Nao came to Japan to reconnect with her Japanese heritage, while Hyejung and Tina came to find freedom and their own paths. Though each of them has her own motivations and challenges, they all deal with language barriers, being a fish out of water, self discovery, love, and family.

Welcome to the world of Leaflings, the secret guardians of the trees.Among the branches and roots of some of our planet's most important inhabitants, live the leaflings. These tiny creatures protect trees and help manage their interactions, their cycles and tell their stories. In A Field Guide to Leaflings, meet leaflings from all over the world and the trees they live with. Travel from an ancient holly tree in Ireland, to a cherry blossom in Japan, and climb to the highest branches of a giant redwood in California. The leaflings will show you how trees breathe, make food, support many forms of life and what they mean to people all around the world.

In this wonderfully festive picture book, Yuval Zommer imagines the Northern Lights' fleeting journey from space to Earth and how they weave a special magic for the animals and people living in the frozen lands below.

After her excitement spins out of control in slapstick comedic scenes kids will love, an energetic young girl discovers how to calm down and be present in the moment.Meena is excited to visit Dada and

When Jinwoo gets his rank reevaluated, the results are even better than hecould have dreamed of...but more importantly, a chance to heal his motherfrom her strange illness falls into his lap. In order to find the cure, hemust make his way further into the Demon’s Castle―and now thatthere’s finally hope at the end of the tunnel, nothing can get in hisway.

Soon to be a major Amazon Prime TV series The final novel in the Wheel of Time series - one of the most influential and popular fantasy epics ever published. 'And it came to pass in those days, as it

In the ninth and latest addition to the New York Times bestselling Spy School series, Ben Ripley faces his nemesis, Murray Hill, on the high seas.Thanks to the evidence Ben uncovered in his investigat

*Features animals that live in the polar regions, in the Arctic Circle and Antarctica*Includes movable parts on every spread*Each spread focuses on a different aspect of living in the polar regions*Co

Who are you when you're alone Starry Night, Blurry Dreams is a collection of graphic poetry about loneliness, love and existing in our world. you are not weakjust becauseyour heart feels so heavyWhen words aren't enough to describe our emotions, this book will offer comfort, joy and a friend in the dark. we all have our own beautiful universe.

Everyone knows that little sisters can be an-noy-ing! So when Ravi gets annoyed with Ruby and breaks her toy car in a rage, everyone goes to bed upset. Ravi wakes up the next morning with a bright red grumpy hat stuck fast on his head! And he can’t get rid of it, no matter how hard he tries... Ravi learns how to swap his grumpy hat for happy socks in this uplifting story about siblings, family life and controlling bad moods.Reviews"Perfectly pitched, gorgeously illustrated and told simply but with sophistication, this is a must-have picture book… a superb exploration of feelings, articulated in a way that even the very young will understand; a book to evoke the strongest feelings of recognition in child and adult reader, and full of humour too"LoveReading, Best Children's Books of 2021"This engaging picture book, with delightful canine characters, explores difficult emotions with young children, helping them to develop empathy and emotional awareness... Colourful illustrations will hel

Save your kingdom in this interactive role-playing adventure, which reads like a graphic novel but also plays like a game It's perfect for fans of all ages who are interested in the exciting world of

Moonimal and Boy are ALWAYS together until, one terrible day, Moonimal gets lost in the woods.How will he survive all alone in the wild? And will he ever find Boy again?Journey through dense forests,

Explore the quirky chaos of Custard Manor as you help Penelope Strudel hunt down her birthday surprise from her Uncle Derek Custard.But watch out - there are puffins about! Penelope Strudel and the Birthday Treasure Hunt is a fun, eccentric search-and-find book perfect for children 5+. Explore every larger-than-life room in Custard Manor with two-page spreads filled with funny details, then crack the codes that lead you to the next room. With a host of wacky wildlife running amok throughout the Manor, children are sure to discover something new with every read.From T-Rex skeletons in the Museum Room to a giraffe in the Orangery, there's a surprise around every corner in Custard Manor. But those naughty puffins have trashed the place! Spot 11 in every room, alongside Crumble the dog, Lawrence the cat and an array of hidden details waiting to be discovered. Get busy spotting each item on the checklist in every room, then put your noggin to use solving a number of puzzles to help Penelope

Over 1,000 Tips for Gardening, Country Cooking, Saving Money, DIY Cleaning Solutions, Home Remedies, and More This comprehensive collection of practical tips covers all aspects of keeping a country home, from painting a wall to removing wine stains, making perfect pastry to making your own window cleaner. In addition, find advice for cleaning carpets, making jam, wallpapering, knitting, sewing, and more Woven throughout are poems and proverbs, legends and lore, making this an enjoyable read and a perfect housewarming gift. "Crisp limp lettuce and celery by placing in a pan of cold water for an hour with slices of raw potato.""If an aluminum pan has become discolored, boil some apple peel in it for a few minutes, then rinse and dry.""Tighten up sagging cane seats of chairs by scrubbing both the top and underside with hot soapy water. Rinse in cold salt water.""Sprinkle salt on paths and brickwork crevices to get rid of weeds and grass.""A needle can be threaded more easily if a little h

Tiny Gardening! is a fun kit that caters to ANY age, for curious minds that are interested in botany, gardening, plants and flowers, all in a cute, approachable format.Enjoy gardening at your fingerti

Mehar, a young bride in rural 1929 Punjab, is trying to discover the identity of her new husband. She and her sisters-in-law, married to three brothers in a single ceremony, spend their days hard at work in the family's 'china room', sequestered from contact with the men. When Mehar develops a theory as to which of them is hers, a passion is ignited that will put more than one life at risk.Spiralling around Mehar's story is that of a young man who in 1999 travels from England to the now-deserted farm, its 'china room' locked and barred.In enforced flight from the traumas of his adolescence - his experiences of addiction, racism, and estrangement from the culture of his birth - he spends a summer in painful contemplation and recovery, before finally finding the strength to return 'home'.

Explore the connections found in nature in this simply stunning picture book that explores the idea of change, both big and small. This sky isthe same sky that was blue, and now isspilling down in dri

The third adventure in this much-loved classic series is re-published for a new audience. 'There was once ONE Happy Lion who lived in the zoo of a little French town. Then there were TWO Happy Lions,

TheBig Fat Notebooks' big step up to high school continues! Announcing Biology,the third in the high schoolseries. With over 5 million copies in print since 2016, and sales escalating every year, theB

From the Emmy-nominated TV writer and New Yorker contributor, a totally new, virtuosic form of memoir: a reconstruction of a beloved grandmother's words and wisdom to tell her family's story with equal parts poignancy and hilarity Bess Kalb saved every voicemail her grandmother Bobby Bell ever left her. Bobby was a force--irrepressible, glamorous, unapologetically opinionated. Bobby doted on Bess; Bess adored Bobby. Then, at ninety, Bobby died. But in this debut memoir, Bobby is speaking to Bess once more, in a voice as passionate as it ever was in life. Recounting both family lore and family secrets, Bobby brings us four generations of indomitable women and the men who loved them. There's Bobby's mother, who traveled solo from Belarus to America in the 1880s to escape the pogroms, and Bess's mother, a 1970s rebel who always fought against convention. But it was Bobby and Bess who always had the fiercest bond: Bobby her granddaughter's fiercest supporter, giving Bess unequivocal love,

Inspired by the true World War II history of the few bookshops to survive the Blitz, The Last Bookshop in London is a timeless story of wartime loss, love and the enduring power of literature. August 1939: London is dismal under the weight of impending war with Germany as Hitler's forces continue to sweep across Europe. Into this uncertain maelstrom steps Grace Bennett, young and ready for a fresh start in the bustling city streets she's always dreamed of--and miles away from her troubled past in the countryside. With aspirations of working at a department store, Grace never imagined she'd wind up employed at Primrose Hill, an offbeat bookshop nestled in the heart of the city--after all, she's never been much of a reader. Overwhelmed with organizing the cluttered store, she doesn't have time to read the books she sells. But when one is gifted to her, what starts as an obligation becomes a passion that draws her into the incredible world of literature. As the Blitz rains down bombs on t

Orangutans are swinging in trees, tigers are prowling stealthily amonst the foliage, Elephants are walking across the savannah, a green turtle is gliding through the coral and pandas are eating and sleeping. Watch them all come to life in this beautiful Pop-up book by Usborne.

A boy who accidentally bonds with a magical Beast must set off on an adventure in the mysterious Woods in this whimsical and cheeky middle grade fantasy debutperfect for fans of Nevermoor and How to T

The bestselling paranormal action adventure manga series Bleach continues in novel form as an all-new threat arises!The Quincies' Thousand Year Blood War is over, but the embers of turmoil still smolder in the Soul Society.... Hikone Ubugino and Tokinada Tsunayashiro's combined powers make a mockery of the strongest of the Soul Reapers, Arrancars, Quincies, and Fullbringers in this epic conclusion to the Can't Fear Your Own World arc! As the Soul Society's secrets are brought to light, the full terror of Tokinada's plan is revealed. In the midst of this, Shuhei Hisagi discovers the true ability of his zanpaku-to and the meaning of its name.Can a blade that controls death also sever the consequences of death? A host of powerful characters-including Kenpachi Zaraki and Grimmjow Zaraki Jeagerjaques-make an appearance in the decisive battle, and the volume is complemented by a generous selection of Tite Kubo illustrations!

Why we must reject the illusory consolations of technology and choose revolution over fascism.We are living in apocalyptic times. In Capital Hates Everyone, famed sociologist Maurice Lazzarato points

莫內喜歡畫光，特別是清晨河面的光。他不跟從傳統的畫法，而是用自己的方式，捕捉眼前轉變的景色。一開始沒有人懂他的畫，但他不氣餒，持續創作，最後讓大家看見畫裡的光和感覺。這本繪本帶我們認識這位愛畫光的畫家，也鼓勵我們用自己的眼睛看世界。A new picture book about the iconic artist Claude Monet, from the Caldecott-Award winning team that created The Noisy Paint Box.Claude Monet is one of the world's most beloved artists--and he became famous during his own lifetime. He rejected a traditional life laid out clean and smooth before him. Instead he chose a life of art. But not just any art: a new way of seeing that came to be called impressionism.Monet loved to paint what he saw around him, particularly the Seine River. He was initially rejected for using bright colors, tangled brushstrokes--condemned for his impressions. But soon art dealers and collectors were lining up each morning to see as Monet saw. Monet, however, waited only for the light. The changing light...each morning he had a dozen canvases on hand to paint a dozen different moments. His brush moved back and forth, chasing sunlight--putting in the

The Shadowhunters must catch a killer in Edwardian London in this dangerous and romantic sequel to the #1 New York Times bestselling novel Chain of Gold, from New York Times and USA TODAY bestselling

Art imitates life in this hilarious, absurdist picture book—one of Jon Agee’s most beloved titles, now back in print.“Outrageous!” the judges cried. “Ridiculous!” Who would dare enter a portrait of a

Bestselling author Jacky Davis and award-winning illustrator Fiona Woodcock celebrate family, love, and imagination in this vibrant and expressive picture book. Father-daughter time shines in this irr

Discover the amazing true story of P-22, the wild cougar living in Los Angeles, in this inspiring picture book.P-22, the famed ';Hollywood Cougar,' was born in a national park near Los Angeles, Califo

A Finalist for the 2022 Jane Addams Children's Book AwardAn NPR Best Book of 2021A New York Times Best Children's Book of 2021A Washington Post Best Book of 2021A Kirkus Reviews Best Children's Book of 2021A Horn Book Fanfare Best Book of 2021In 1938, twenty-nine-year-old Nicholas Winton saved the lives of almost 700 children trapped in Nazi-occupied Czechoslovakia--a story he never told and that remained unknown until an unforgettable TV appearance in the 1980s reunited him with some of the children he saved.Czech-American artist, MacArthur Fellow, and Andersen Award winner Peter S s dramatizes Winton's story in this distinctive and deeply personal picture book. He intertwines Nicky's efforts with the story of one of the children he saved--a young girl named Vera, whose family enlisted Nicky's aid when the Germans occupied their country. As the war passes and Vera grows up, she must find balance in her dual identities--one her birthright, the other her choice.Nicky & Vera is a mas

Go on a snowy, sandy shore walk in a story where every single word starts with the letter S!Explore the beach in winter in this story told through clever language. During a sunset beach saunter, a girl stumbles and drops her doll into a tidal pool. Soaked! Celebrating the natural silence of an off-season location, the surf and sand are brought to life through this engaging story.

In Burmese Days, George Orwell, one of the most famous writers in the English language, draws on his own experience of living and working in Burma to write an unflinching novel about the dark side of

In La Vita Nuova, Italy's greatest poet recounts the famous story of his passionate love for Beatrice. The drama of their relationship unravels through stunning poetry and prose in this, one of the mo