Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

On an island nation in the Indian Ocean, the explorers venture through a vast underwater world and take part in a friendly robotics competition. But the tides of good fortune change quickly. Suddenly,

Now a limited series on HBO Max starring Kaley Cuoco and Rosie Perez, a powerful story about the ways an entire life can change in one night: a flight attendant wakes up in the wrong hotel, in the wro

Learn how animals around the world show their love in this interactive board bookLove is strong.You have my back and I’ll always have yours.Animals show their love in so many ways! This interactive bo

In this award-winning book inspired by true events, 7th grade turns out to be anything but normal when teachers announce the students' bloodless revolution succeeded and they are now in charge. After

Think metric! A fun illustrated primer on the internationally recognized metric system for kids.Used in almost every country in the world, the metric system is an easy-to-use way of calculating length

The bestselling paranormal action adventure manga series Bleach continues in novel form as an all-new threat arises The Quincies' Thousand Year Blood War is over, but the embers of turmoil still smolder in the Soul Society... Hikone Ubuginu's mysterious origin story, and the secrets behind the very existence of the Soul Reapers and all their allies and adversaries, could be revealed to incite an all-out battle royal. Meanwhile, Urahara and Hisagi face down formidable enemies in Karakura Town as Tokinada Tsunayashiro's fiendish plan unfolds

Discover this gothic tale of outcasts, friendship and Notre-Dame Cathedral in Paris. When French author Victor Hugo wrote Quasimodo’s story in 1831, he wanted to make people think about what it meant

Floating across the sky in her hot air balloon, Cassi watches a little swift dive and swoop through the still air. In the rising sun the world seems to be holding its breath. Then a small breeze stirs

Animals inspire their little ones to chase their dreams and reach for the stars in this modern classic-in-the-making from New York Times-bestselling author Beth Ferry and Caldecott honoree Molly Idle.

A group of clever animals find an unusual but warm and furry home during Alaska's long winter in Jan Brett's newest snowy adventure.Cozy is the softest musk ox in Alaska, with the warmest fur you ever

A timely and timeless picture book about immigration, refugees, acceptance, and tolerance from a NYT bestselling author. A young Parsi girl in modern times comes from India to live in America with her

Celebrating science and the poetry of existence, this is a true story about time and chance, genetics and gender, love and death—all made more accessible to the young imagination in the concrete, finite life of one tiny snail named Jeremy.★ A Kirkus Best Book of 2021: A Best Informational Picture Book★ A Marginalian (formerly Brain Pickings) Best Children’s Book of 2021★ A Spirituality & Practice Best Spiritual Book of 2021Based on a real scientific event and inspired by a beloved real human in the author’s life, this is a story about science and the poetry of existence...The Snail with the Right Heart is a story about time and chance, genetics and gender, love and death, evolution and infinity—concepts often too abstract for the human mind to fathom, often more accessible to the young imagination; concepts made fathomable in the concrete, finite life of one tiny, unusual creature dwelling in a pile of compost amid an English garden. Emerging from this singular life is a lyrical un

Watch six breathtaking landscapes from around the world transform in front of your eyes, in this beautifully illustrated book. With simple facts about the wildlife and plants that change through every

A star-scattered night, a brand new baby boy, and all the potential in the world… This is a poetic introduction to what it means to be a boy in the challenging times we live in, and all of the dazzlin

In Small Worlds Earth, explore nature up close. Look at what happens under the leaf litter in a forest, find out what lives in a single desert oasis, examine the top of a Brazil nut tree in the Amazon and much more. What will you find when you explore these small worlds? Prepare to be surprised by the variety of life on each page of this gorgeous lift-the-flap book.A fascinating exploration of the life and cycles in nature's small worlds.

This book, written by an internationally acknowledged pioneer in endocrine surgery, is intended as advice for aspiring medical professionals, in particular for young people from around the world who a

In a small back alley in Tokyo, there is a café which has been serving carefully brewed coffee for more than one hundred years. But this coffee shop offers its customers a unique experience: the chanc

A young meerkat travels the world looking for Christmas in this witty and festive picture book full of cards that readers can flip open to read!Sunny Meerkat isn't quite sure if Christmas in the Kalahari Desert with his meerkat family is the right sort of Christmas. After all, there's no snow, no Christmas trees, and certainly no holiday treats! Sunny sets off on a journey around the world visiting robins, penguins, and reindeer in search of the picture-perfect Christmas...before realizing he might have left it at home after all.

Winner of the Blue Peter Book Award 2021Short listed for Sainsbury's Children's Book Awards 2021If you've ever wanted to know what a panda does all day long, how your heart manages to shift all that blood around your body or what makes a rainbow shine, you've come to the right book. A Day in the Life of a Poo, a Gnu and You features the answers to all of these questions and many more, all told in a super-fun comic book format in three awesome sections: Human Body, Animal Kingdom and Earth and Science. A Day in the Life... is packed with facts, laughs and amazing illustrations you can dive into all day long. Meet your grumpy liver that has to do practically EVERYTHING; your trusty hands that are very, well, handy; the spiky porcupines ready to charge; lonely Mars rovers abandoned on the Red Planet; raging tornadoes ready to rip through the pages of the book and bubbly volcanoes ready to blow. All entries are told in the fun, friendly and informative style of Mike Barfield, and are broug

You probably remember the story of the bear who found the piano in the woods and grew up to become a huge star. He played his music in front of millions of adoring fans and all of his wildest dreams c

Meet a big, friendly dog looking for a home in this warm and reassuring story by award-winning Marta Altes.This dog may be alone and without a home, but he’s excited and ready to embrace a new life in

Two leaders in the field offer a compelling analysis of the current state of the art and reveal the steps we must take to achieve a robust artificial intelligence that can make our lives better.“Finally, a book that tells us what AI is, what AI is not, and what AI could become if only we are ambitious and creative enough.” —Garry Kasparov, former world chess champion and author ofDeep ThinkingDespite the hype surrounding AI, creating an intelligence that rivals or exceeds human levels is far more complicated than we have been led to believe. Professors Gary Marcus and Ernest Davis have spent their careers at the forefront of AI research and have witnessed some of the greatest milestones in the field, but they argue that a computer beating a human in Jeopardy! does not signal that we are on the doorstep of fully autonomous cars or superintelligent machines. The achievements in the field thus far have occurred in closed systems with fixed sets of rules, and these approaches are too narro

'Carter is now in the Jeffery Deaver class' Daily Mail FROM THE AUTHOR OF THE SUNDAY TIMES NUMBER ONE BESTSELLER HUNTING EVIL COMES THE NEXT COMPULSIVE THRILLER IN THE ROBERT HUNTER SERIES A serial k

The essential guide to sowing, growing, and preparing herbs for homesteadersGrowing herbs means growing your own food, home remedies, beauty products, and more. This homesteader’s handbook is packed with expert information on planting, caring for, and using herbs to nourish and nurture yourself, your family, your pets, and even your livestock.Learn about the countless perks of cultivating herbs on your homestead, find tons of info on foraging and growing, and get a step-by-step guide to creating your own herbal teas, tinctures, salves, and more. Who knew your own soil had so much potential?This standout among homesteader books includes:Garden planning—Discover a helpful guide to planning an herb garden, from selecting plants to deciding the size and location of your growing area.An herb encyclopedia—Explore an informational index of common household herbs, including the parts used, plant properties, safety considerations, preservation methods, and much more.A range of recipes—Try dozen

In the 30th Berenstain Bears Level 1 I Can Read adventure, Brother, Sister, and Honey see something spooky at the old theater in town.When Brother, Sister, and Honey need a summer job, they see that t

The true, behind-the-scenes history of the people who built Silicon Valley and shaped Big Tech in America Long before Margaret O'Mara became one of our most consequential historians of the American-led digital revolution, she worked in the White House of Bill Clinton and Al Gore in the earliest days of the commercial Internet. There she saw firsthand how deeply intertwined Silicon Valley was with the federal government--and always had been--and how shallow the common understanding of the secrets of the Valley's success actually was. Now, after almost five years of pioneering research, O'Mara has produced the definitive history of Silicon Valley for our time, the story of mavericks and visionaries, but also of powerful institutions creating the framework for innovation, from the Pentagon to Stanford University.It is also a story of a community that started off remarkably homogeneous and tight-knit and stayed that way, and whose belief in its own mythology has deepened into a collective

A heart-wrenching true story about life in a Kenyan refugee camp that will restore your faith in real-life happy endings.Omar and his brother Hassan, two Somali boys, have spent a long time in the Dadaab refugee camp. Separated from their mother, they are looked after by a friendly stranger. Life in the camp isn't always easy. The hunger is constant . . . but there's football to look forward to, and now there's a chance Omar will get to go to school . . .With a heart-wrenching fairytale ending, this incredible true story is brought to life by Victoria's stunning illustrations. This book perfectly depicts life in a refugee camp for 8-12 year olds.'Does everything one can ask of a book, and then some.' Kirkus'Fantastic graphic novel.' The New York Times Book Review'Sensitive and poignant.' School Library Journal'Not to be missed.' Booklist

The warrior cats leap off the page in their first-ever original full-color adventure-a stand-alone graphic novel set in the wild world of Erin Hunter's #1 bestselling Warriors series. When RiverC

"Two families flee extreme weather in India and come together on a mountaintop"--

《The 7 Habits of Highly Effective People》自出版以來，影響無數領導者、教育者與家庭，被譽為二十世紀最具影響力的商業書之一。本書以七項核心習慣為指引，從「積極主動」到「不斷更新」，帶領讀者建立以原則為中心的人生與工作模式。Stephen R. Covey 的觀點清晰、具啟發性，結合理論與生活實例，提出一條兼顧誠信、責任與人際理解的成長之路。三十週年新版由 Sean Covey 加入當代觀點，使經典智慧在新時代延續。・暢銷超過四千萬冊的領導學經典・以七大習慣構築個人與團隊的高效思維・融合實踐方法與自我省思，跨越時代仍具啟發力*New York Times bestseller―over 40 million copies sold**The #1 Most Influential Business Book of the Twentieth Century*One of the most inspiring and impactful books ever written, The 7 Habits of Highly Effective People has captivated readers for nearly three decades. It has transformed the lives of presidents and CEOs, educators and parents―millions of people of all ages and occupations. Now, this 30th anniversary edition of the timeless classic commemorates the wisdom of the 7 Habits with modern additions from Sean Covey.The 7 Habits have become famous and are integrated into everyday thinking by millions and millions of people. Why? Because they work!With Sean Covey’s added takeaways on how the habits can

It's time to fight back in this second novel in a thrilling, subversive near future series from New York Times bestselling author Suzanne Young about a girls-only private high school that is far more

An elephant firefighter? A traffic cop sloth?A paramedic chimpanzee? What a catastrophe! In case of emergency, you’d do best to avoid ALL of these creatures. Find out why in this hilarious picture boo

Where Are You, Agnes is a stunning imagining of abstract artist Agnes Martin’s childhood and the ways in which it may have shaped her work as an adult.Agnes Martin was born on the Canadian prairies in

The fifth official Minecraft novel from Mojang and Del Rey.Stax Stonecutter has lived a peaceful—if unremarkable—life in his small town in the Overworld. He prefers leisure to work, choosing to tend t

The prince imagines the fort in the woods as his castle, but the pirate imagines it as her ship—who will win their creative tug of war?In the fort in the woods, a prince is preparing his castle for a

A Paperback Original—Also Available as a Hardcover Library EditionIn this sharply observed novel set in and around London, three college friends, now in their thirties, must come to terms with the gap between the lives they imagined for themselves and reality in the face of marriage, fertility struggles, and loss.In her first year of motherhood after an unplanned pregnancy, Cate is constantly exhausted, spiraling into self-doubt and postpartum anxiety. Her husband Sam seems oblivious, but maybe she’d prefer he remain in the dark. How can she admit the unthinkable—that she misses her freedom?In contrast, Hannah continues to endure round after round of unsuccessful IVF treatments. The process is taking its toll on her physically and emotionally—and, she worries, creating distance between her and her husband Nathan. She is godmother to Cate’s son, but every time they get together, it’s a trigger.Beautiful and unattached, Lissa is re-evaluating what it means to be an actress in her thirtie

Two mommies spend a sunny day with their toddler in this cozy, rhyming picture book that is a loving celebration of family.This cheerful book follows a family from morning to night in lively rhyme tha

In this book from the critically acclaimed Little People, BIG DREAMS series, discover the inspiring story of this iconic singer-songwriter, poet, and artist.Bob Dylan was born in Duluth, Minnesota. As

From Ashima Shiraishi, one of the world's youngest and most skilled climbers, comes a true story of strength and perseverance--in rock climbing and in life.To a rock climber, a boulder is called a problem, and you solve it by climbing to the top. There are twists and turns, falls and scrapes, and obstacles that seem insurmountable until you learn to see the possibilities within them. And then there is the moment of triumph, when there's nothing above you but sky and nothing below but a goal achieved.Ashima Shiraishi draws on her experience as a world-class climber in this story that challenges readers to tackle the problems in their own lives and rise to greater heights than they would have ever thought possible.

Translated by Alison L. StrayerWinner of the Nobel Prize in Literature 2022 | Co-funded by the Creative Europe Programme of the European Union‘I too wanted to forget that girl. Really forget her, that is, stop yearning to write about her. Stop thinking that I have to write about this girl and her desire and madness, her idiocy and pride, her hunger and her blood that ceased to flow. I have never managed to do so.’ In A Girl’s Story, her latest book, Annie Ernaux revisits the summer of 1958, spent working as a holiday camp instructor in Normandy, and recounts the first night she spent with a man. When he moves on, she realizes she has submitted her will to his and finds that she is a slave without a master. Now, sixty years later, she finds she can obliterate the intervening years and return to consider this young woman whom she wanted to forget completely. In writing A Girl’s Story, which brings to life her indelible memories of that summer, Ernaux discovers that here was the vital, vi