Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Infiltrate. Befriend. Sabotage.World War II is raging. Michael O'Shaunessey, originally from Ireland, now lives in Nazi Germany with his parents. Like the other boys in his school, Michael is a member

A follow-up to the best-selling The Storm Whale, winner of the 2014 inaugural Oscar's First Book Prize in association with the Evening Standard. It’s winter time and Noi’s island is covered in a blank

In this vivid and compelling novel, Tim Murphy follows a diverse set of characters whose fates intertwine in an iconic building in Manhattan s East Village, the Christodora. The Christodora is home to

In 1960, Joy Adamson first introduced to the world the story of her life alongside Elsa - the lioness she had rescued as an orphaned cub and raised to adulthood at her home in Kenya. But, as Elsa had

A novel of social and moral themes, Hard Times is the archetypal Dickens novel, filled with family difficulties, estrangement, rotten values and unhappiness. Published in 1854, it is set in the imagin

Set in the South of France in the decade after the First World War, Tender is the Night explores the new world of moneyed leisure found by the first generation of idle-rich Americans to take refuge in

Chart an unforgettable journey in your trusty canoe down the Amazon river with this beautifully illustrated 16-panel concertina pull-out wall frieze. Learn just how unique and important this fascinating place is as you wind past colourful communities, busy jungle cities, and incredible rainforest creatures and wacky wildlife, from high up in the Andes of Peru, to the bustling city of Belem in Brazil. Then turn the frieze over to discover loads of fascinating facts about each point of interest encountered along the journey, from pink river dolphins to a disappearing tribal village.Each title in our Unfolding Journeys series has its own distinct artwork style. Unfolding Journeys - Amazon Adventure's contemporary illustrated icons are etched in black and white against the bright greens, blues and pinks that encapsulate the Amazon's history and landscape. Part of our Unfolding Journeys range Also available: Unfolding Journeys: Rocky Mountain Explorer.Collect them all! About Lonely Planet K

Challenges young readers to find named objects in busy fold-out scenes set in the city, the country, at the sea, in the mountains, and in the air.

Little children can listen to a baby bird tweeting, frogs croaking in the pond and owls hooting when they press the pages of this delightful book. Colourful pages show the garden and pond in the sun a

All legends begin somewhere, and the two novels here are where one of the world's best-loved legends began. In A Study in Scarlet, Sherlock Holmes and Dr Watson first meet and investigate a seemingly

An exciting book for all middle schoolers (6th-8th grade) who wish they had taken better notes in american history class or just want to jump to the head of the class. Each Big Fat Notebook is like getting to borrow the notebook of the best student in American history class, the one who not only writes down the important points the teacher makes—noting those crucial “you will get tested on these” facts—but also meticulously transcribes key points from the chalkboard and pastes teacher handouts into her notebook. Part “CliffsNotes,” part workbook, this study hack will help kids focus on the things they need to remember in order to rock their middle school exams and ace american history.Each notebook was written by a graduate of a prestigious university, and all the writers graduated with honors in their respective subjects.Everything You Need to Ace American History in One Big Fat Notebook is based on state standards and has been vetted by a middle school American history teacher

In the spirit of Mindy Kaling’s bestseller Is Everyone Hanging Out Without Me?or Judd Apatow’s Sick in the Head, a collection of humorous, autobiographical essays from Kunal Nayyar, best known as Raj

A picture hides a thousand words ...On a hot July day in 1967, Odelle Bastien climbs the stone steps of the Skelton gallery in London, knowing that her life is about to change forever. Having struggle

Frederic Henry is an American Lieutenant serving in the ambulance corps of the Italian army during the First World War. While stationed in northern Italy, he falls in love with Catherine Barkley, an E

Serafina's defeat of the Man in the Black Cloak has made it impossible for her to keep hiding in the basement of Biltmore estate. No longer the secret resident and rat catcher extraordinaire who explo

**2016 Man Booker Prize Longlist In Canada in 1991, ten-year-old Marie and her mother invite a guest into their home: a young woman who has fled China in the aftermath of the Tiananmen Square protests

The final chapter in Sergei Lukyanenko's internationally bestselling Night Watch series—a revelatory urban fantasy set in contemporary Moscow.They live among us. They fight among us. They’re the Other

In the winter of 1954, in a construction camp in the remote Tasmanian highlands, when Sonja Buloh was three years old and her father was drinking too much, her mother disappeared into a blizzard never

Animals eat animals in this informative exposé of three animal food chains Three of the longest food chains of the animal kingdom are depicted in three accordion-foldout volumes, complete with stunnin

本書描寫一位小女孩親手打造自己的娃娃屋，從外牆的磚紋、室內的壁紙，到替娃娃縫製的衣服，甚至用紙杯做成的小小電梯，每個細節都來自她的想像與雙手。她對這座獨一無二的家感到驕傲，也在其中玩得不亦樂乎。直到有一天，她看見朋友 Sophie 那棟「完美」的現成娃娃屋——所有配件一應俱全，連馬桶蓋都能掀起。兩人一番比較之後，逐漸發現，真正好玩的並不是什麼都齊備，而是能自由改造、反覆想像的空間。A girl makes her own dollhouse in this picture book that celebrates creativity and imagination!A little girl proudly walks the reader through her handmade dollhouse, pointing out the bricks she painted on the outside, the wallpaper she drew on the inside, the fancy clothes she made for her dolls, and the little elevator she made out of a paper cup. She’s proud of her house and has lots of fun using her imagination to play with it—until she discovers her friend Sophie’s “perfect” storebought house. Sophie thinks her house, with everything matching and even a toilet seat that goes up and down, is pretty perfect too, until both girls discover that the narrator’s handmade dollhouse is really a lot more fun."Celebrates the best of free play, capturing what it's like to be fully engaged and inspired." —

"Shortly after her college graduation, Frances flees a painful breakup and her claustrophobic childhood home in Manhattan, which has become more airless in the aftermath of two family announcements: h

An outrageously stylish, wickedly funny novel of fashion in the digital age,The Knockoff is the story of Imogen Tate, editor in chief of Glossy magazine, who finds her twentysomething former assistant

Reading takes many forms. Some of us read novels, while others read cookbooks, sheet music, tarot cards, or even the stars in the sky. We read clocks, train schedules, and facial expressions. In this

Now you can color DC Comics and all of its most popular characters your way with DC COMICS COLORING BOOK: BATMAN ADVENTURES: MAD LOVE! DC Comics presents classic adventures in a whole new way: in blac

Two couples. Friendship, suspicion, deceit. And the truth. Florian Zeller's The Truth, in the English translation by Christopher Hampton, premiered at The Chocolate Factory, London, in association wit

Have you ever sped past in such a hurry that everything you passed was soft and blurry? And did you ever squeeze your eyes so tight that you saw lots of dots of coloured light? In Did You Ever See? Jo

A runaway bestseller in the UK—Matt Haig’s accessible and life-affirming memoir of his struggle with depression, and how his triumph over the illness taught him to liveLike nearly one in five people,

The Famous Five celebrated 70 years in print in 2012 - but the celebrations are still continuing! Everyone loves reading the adventures of Dick, Anne, Julian, George and, of course, Timmy!

Evelyn has no interest in marriage and even the dashing Mr. Kent can't make her want to live up to society's expectations. She'd much rather assist her beloved sister Rose in becoming the world's firs

It’s a rainy day in the month of May and Sam spots a rainbow, and then a puddle. A perfect spring puddle. His mother warns, No! No jumping in puddles! You must keep clean today!” but Sam can’t stop hi

An audacious jewel heist. A murdered actress. A killer case for NYPD Red. In a city where crime never sleeps, NYPD Red is the elite task force called in only when a case involves the rich, famous, an

Stina, who lives in Iceland, does not like the cold. In fact, she will go to any length to avoid it. Even in summer she never goes out without tights and socks. When winter comes, she hides inside, kn

Into the Snow is an immediate depiction of a child playing, experiencing the sensory joys of winter and independence.Into the Snow is an exuberant story told in the child's own voice. Celebrating immediacy and exploration, along with the tender bond between mother and child, this is a story that feels good, the way all real things do.Masamitsu Saito was born in 1958 in Japan. He studied graphic design at Tama Art University. His work can be found in magazines, on chocolate packages, and inside wonderful books.Yuki Kaneko is an artist, naturalist, translator, and author. She grew up in Japan, and now lives in Brooklyn with her husband and daughter.

根據國際知名諮詢公司麥肯錫的報告顯示：在大數據應用綜合價值潛力方面，資訊技術、金融保險、政府及批發貿易四大行業潛力最高。具體到行業內每家公司的數據量來看，資訊、金融保險、計算機及電子設備、公用事業四類的數據量最大。而以中國為例，金融業大數據的投資規模為第三名，占據了17.5%，由此可看出，無論企業的規模大小及歷史長短，大數據已全面性地走入了各行各業。而根據研究機構國際數據資訊（Internatio

DescriptionThe Workplace Success series prepares students for working in an English-speaking job environment. All four English skills-reading, listening, speaking and writing-are included in each unit

The global expansion of judicial powers makes no exception to Asia. Most noticeable is the judicial expansion in tandem with unprecedented political and legal reforms that have occurred in the two Asi

Bill Bryson’s first travel book opened with the immortal line, ‘I come from Des Moines. Somebody had to.’ In this deeply funny and personal memoir, he travels back in time to explore the ordinary kid

Mr. and Mrs. Eiffel are a happy couple enjoying living in the most romantic city in the world, Paris. Until one day, Mrs. Eiffel begins to feel desperately unwell. The experts are unanimous: the only

In 1996, poet Leah Lakshmi Piepzna-Samarasinha ran away from America with two backpacks and ended up in Canada, where she discovered queer anarchopunk love and revolution, yet remained haunted by the

A vibrant and playful seek-and-find picture book by the acclaimed Swedish artist and designer Laura Ljungkvist, in which the reader uncovers animals hidden in a dazzling array of patterns and colors.