Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

They're the windows to your soul and the tools you use to perceive light and colors. When your dog stares at you with them in a particularly sad way, you can't help but toss him a treat. What

The most merciful thing in the world, I believe is humanity’s failure to fully conceive the cosmical horrors we’ve yet to reveal, and which up until now I have tried to conceal.The iconic H.P. Lovecra

From the author of If I Could Keep You Little comes Be Brave Little One, which honors and celebrates the power of courage in every child. Perfect for cheering someone on, this story affirms how braver

The second arc of Providence is unveiled in this special hardcover-only edition.Robert Black came looking for a story but what he found is a world of misery and woe.He's becoming a broken man, only be

If you're like most kids who love the outdoors, you want to do more than go on picnics or hike a nature trail. You don't want to go home at the end of the day. You want to stay out in the woods, mount

Discourses of degeneration (social, political, medical) peaked in the 1890s, and posited the decline, even sterility of white European races.

In The Case for Impeachment, Distinguished Professor of History at American University Allan J. Lichtman illuminates exactly how the impeachment of President Trump might work by showing how his action

The International Who’s Who in Classical Music 2017 is a vast source of biographical and contact information for singers, instrumentalists, composers, conductors, managers and more. Each entrant has

Jean Nouvel speaks of the similarities between film and architecture, Robert Venturi finds ideas in `gas stations as well as Borromini and Chartres', James Stirling believed that the best architecture

For courses in quantitative reasoning, quantitative literacy, numeracy, or liberal arts mathematics for non-STEM students. Empowerment through Numbers Thinking Quantitatively: Communicatin

This book explores the meaning of thankfulness by asking the central character, a young boy, to think about the people in his life he'd like to thank, from his Mom and Dad, to his babysitter and sport

There’s a fine line between real life and video games in this engrossing novel that’s part Kathryn Erskine’sMockingbird, part Patrick Ness’s A Monster Calls. Severkin is an elf who slinks through

One of the most beautiful ways to know God better is to learn from those who served Him in other times and cultures. The poets and saints of Christian history were imperfect, yet they offer wisdom acr

The maestro storyteller and reporter provocatively argues that what we think we know about speech and human evolution is wrong.Tom Wolfe, whose legend began in journalism, takes us on an eye-opening j

A funny, fantastically entertaining debut novel, in the spirit of Wodehouse and Monty Python, about a famous poet who inadvertently sells his wife to the devil--then recruits a band of adventurers to

Here is the eighth—and final—title in Edgar Award Winner Dori Hillestad Butler's not-too-scary chapter book mystery series, The Haunted Library.Kaz are Claire are called on for another case!

This imaginative new fantasy will charm fans of the Ranger’s Apprentice and Rick Riordan.Denizen Hardwick is an orphan, and his life is, well, normal. Sure, in storybooks orphans are rescued from drud

For readers of Station Eleven and The Martian, Lily Brooks-Dalton’s haunting debut is the unforgettable story of two outsiders—a lonely scientist in the Arctic and an astronaut trying to return to Ear

A novel, spanning several generations, which draws us into the complicated world of a family in California after the sudden death of the father.Beginning with forty-three-year-old Michael Gannon's fat

With a Foreword by Bill O’Reilly, here is the incredible memoir of a former Marine who returns to combat in Iraq and Afghanistan three decades after leaving the Corps.Terry McGowan had been a beat cop

From the author of Ophelia and the Marvelous Boy comes the story of a friendship between two girls set in Victorian England, with magical machines, wizards, witches, a mysterious underworld, and a rac

The definitive guide to the art and science of lens design—fully updated to reflect the latest advancesThis benchmark optical engineering resource offers an encyclopedic overview of all forms of lenses and optical systems. Revised from start to finish, this new edition brings all existing content up to date and adds new sections on design advances from the last 10 years. With this book in hand, there's no lens that you can't design.Modern Lens Design, Third Edition, leads you through the fundamentals and hands-on practices of optical engineering, covering time-tested methods for designing top-quality lenses. Long a paragon of design instruction, the book provides clear explanations, examples, and hands-on instruction and fully covers the latest software and optimization techniques.Features new coverage of cell phone cameras, panoramic and 360-degree lenses, and large-format focal planesClarifies and consolidates a wide range of crucial lens design informationTwo industry-recognized exp

In Victoria Laurie’s new Psychic Eye mystery, Abby Cooper learns that following the money often leads to murder . . . Professional psychics learn to deal with skeptics, but Abby has to prepare he

Bill is a young Teddycat, which means he’s one of the most special--and mysterious--animals in the jungle. Teddycats can climb higher than any other mammal around. And because the Teddycats can climb

A new case of unsolvable murders brings Hell to Heaven in the explosive sequel toThe Devil's Detective. Hell is burning out of control. Thomas Fool, Hell's first Information Man tasked with investigat

The author describes her experience hidden away by her wealthy Chicago parents in a dreary government facility for impoverished pregnant teens after she discovered she was accidentally expecting at ag

The funny follow-up to Kindergarten, Here I Come!First grade—it's the big time! After all, it's a real honest to goodness grade. In verses that are both funny and full of heart, D.J. Steinberg celebra

In the tradition of Black Dog's best-selling Child's Introduction books, which include The Story of the Orchestra and A Child's Introduction to the Night Sky, A Child's Introduction to Natural History

As the controversies surrounding President Obama’s immigration enforcement policies demonstrate, we tend to examine the immigration dilemma from the top down. Reflecting their backgrounds in law and s

In the vein of Alice Sebold’s Lucky, comes a compelling, real-life crime mystery and gripping memoir of the cold case prosecution of a serial rapist, told by one of his victims.On the morning of Septe

In an age when almost anything can be somehow quantified and then measured, Sally Engle Merry’s latest book shows how quantification can hide or even distort as much as it reveals. She is particularly

Complete Atlas of the World, Third Edition is now fully revised and updated to reflect the latest changes in world geography, including the annexation of Crimea and the new nation of South Sudan. Brin

Everything that is great about the American automobile is presented in this full color, beautifully depicted guide. It includes all of your favorite American models; Chevrolet, Chrysler, Dodge, Ford,

A gift-worthy playbook of common and unexpected words and phrases that have their roots in sports and games. The language of sports resonates beyond the grass and dirt of the local ball field bec

Originally paved in the 1920s, Route 66 has been a staple of the American Road Trip through the Great Depression and was a major method of the bootlegging operation. Spanning a total of 8 states and s

"Sally tries to tell her family that a hippo, a tiger, zebras and koalas are in their yard, but no one pays attention until they hear that the zoo animals have escaped; now everyone panics except for

Both comparative criticism and translation cross borders, yet borders that have been crossed still exist. Even a border that has been dismantled is likely to reappear in a different place, or as a les

In this 2014 Notable New York Times Book Review Children Books, Hall and Tolstikova celebrate a child's love for her favorite book.

"Unwrap" the mystery of mummies with this fun and educational toy.Embalm your own mummy! Discover ancient burial rituals! Freak out your family members! This exploration kit combines lessons in scienc

NOTE: This edition features the same content as the traditional text in a convenient, three-hole-punched, loose-leaf version. Books a la Carte also offer a great value—this format costs significantly