Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Press the soft patches to hear the skeleton and its friends come to life in this hilarious Halloween treat.You'd better not tickle the skeleton... because it might just rattle if you do!Babies and toddlers just won't be able to resist tickling the touchy-feely patches to hear each creature make a sound in this hilarious novelty book. At the end, readers will find all the characters gathered together for a spooktastic Halloween dance. An exciting series for babies and toddlers, from the creators of That's not my...Withover 20 books to discover in this award-winning series, there is a book to excite every baby and toddler; including dinosaurs, bears, tigers, unicorns and lots more - giggles are guaranteed!Every DON'T TICKLE book supports sensory development with:- Engaging characters to encourage playfulness- Furry patches for developing motor skills- Playful music to inspire movement- Holes to peep through, sparking curiosity- Rhythmic text for developing language

Get ready for bed in this big board format with three games to play on every page!Pip and Posy are going to bed. They need to have a snack, brush their teeth and have a wash before it's time to read a bedtime story. This chunky board book is the perfect way to make the bedtime routine fun, with 36 sliders and three games to play but none of the mess of a card game!Designed to aid a chil'd's memory and language development, with simple labels to build vocabulary and lots of things to spot.Other titles to collect: The Super Seasons

This is the way we brush our teeth.Do you know what to do?First open up the cupboard.Now which brush belongs to you?Get ready to brush your teeth in this adorable slider book, full of gentle messages to help little ones with their daily routines.This rhyming story is perfect for reading aloud together with toddlers, building familiarity and confidence about tooth-brushing, and introducing some fun ideas for all the family to try. Little ones will love to slide the toothbrush from side to side, turn the wheel to make water come out of the tap and lift a flap to see teddy brush his teeth.For parents and carers, each page features short practical tips to help you and your child, consulted by Early Years expert Lizzie Noble.

You'd better not tickle the dolphin... because it might just squeak if you do!Babies and toddlers just won't be able to resist tickling the touchy-feely patches to hear each sea animal make a sound in this hilarious novelty book. At the end, readers will find all the sea creatures being noisy at once in a musical finale guaranteed to get little ones dancing along.An exciting new series for babies and toddlers, from the creators of That's not my... With over 20 books to discover in this award-winning series, there is a book to excite every baby and toddler; including dinosaurs, bears, tigers, unicorns and lots more - giggles are guaranteed! Every DON'T TICKLE book supports sensory development with:- Engaging characters to encourage playfulness - Furry patches for developing motor skills- Playful music to inspire movement- Holes to peep through, sparking curiosity - Rhythmic text for developing language

A BIG book for sharing with a little person, introducing things that go, first words, colours, numbers and more – with felt flaps and a mirror!With bright, stylish artwork from Ingela P Arrhenius, illustrator of the internationally bestselling Felt Flaps and Peekaboo series, this BIG vehicle-themed playbook is perfect for sharing with older babies and toddlers. How many cars can you count? What colour is the fire engine? What noise does the train make? And finally, where are you?A brilliant large-format board book introducing early-learning first concepts and encouraging interactive play, with 10 soft felt flaps, tactile die-cuts on every page and a surprise mirror ending.Other titles available in the series:My BIG PlaybookMy BIG Playbook: FarmMy BIG Playbook: Nature

Follow Little Robin on a flight from the city to the jungle, visiting ten different kinds of birds from around the world.Little Robin wakes up early and flies away from the nest on an adventure, meeting over ten species of birds from all over the world, from garden sparrows to city magpies, soaring bald eagles to flightless kiwis. Little Robin’s Book of Birds is a delightful, colorful treat, ending with a quiet nighttime scene perfect for winding down at bedtime.This reimagining of the author’s bestselling The Big Book of Birds is designed to instill an early love and curiosity for the natural world and its wonderous wildlife. Packed with sound effects and simple phrases to engage babies with Yuval Zommer’s gorgeous illustrations, this chunky board book is perfect for Zommer fans and any child who loves the sound of birdsong.

和小貓一起出發環遊世界，猜猜牠會去哪裡旅行呢？這本可重複使用的魔法水畫書，操作簡單，只要加水就能讓隱藏的圖案和色彩一一浮現。書中有七幅生動場景，畫面乾了還能再玩，適合孩子透過輕鬆的塗畫體驗，發現旅行的驚喜與樂趣。Help Cat get ready for a holiday adventure in this 100% reusable and 100% fun magic water painting book!Join Cat on a holiday adventure around the world. But which countries does Cat visit? Simply pick up the brush pen, paint the magical pages with water, and find out!To bring the seven adorable pictures to life, just add water to the magic painting pen and paint over the white spaces on each right-hand page. You'll gaze with wonder as colour magically appears with each brush of the pen and hidden pictures are revealed.With pictures to discover in every scene, children can colour in the pictures with the magic painting pen included in this book. Using the book is super-simple. Just unscrew the pen tip, add water, then screw back on, and your pen is ready to use! The book is 100% reusable too, with specially designed pages that can be used again and again.Once the water dries on eac

A funny flip-the-flap book from the classic world of Dr. Seuss, perfect for babies and young children!An introduction to a variety of shapes and the world of Dr. Seuss, perfect for babies and toddlers!Flip the flap – what can you see? Full of Dr. Seuss’s craziest characters and wittiest rhymes, this brilliant board book explores a variety of shapes.Bright, vibrant and with interactive flaps throughout, the Flip-the-Flap books are brilliantly designed for introducing early concepts to babies and toddlers and offer a perfect first step into the wonderfully wacky world of Dr. Seuss.

A funny flip-the-flap book from the classic world of Dr. Seuss, perfect for babies and young children!An introduction to crazy colours and the world of Dr. Seuss, perfect for babies and toddlers!Flip the flap – what can you see? Full of Dr. Seuss’s craziest characters and wittiest rhymes, this brilliant board book explores a range of colours.Bright, vibrant and with interactive flaps throughout, the Flip-the-Flap books are brilliantly designed for introducing early concepts to babies and toddlers and offer a perfect first step into the wonderfully wacky world of Dr. Seuss.

A funny flip-the-flap book from the classic world of Dr. Seuss, perfect for babies and young children!An introduction to numbers and the world of Dr. Seuss, perfect for babies and toddlers!Flip the flap – what can you see? Full of Dr. Seuss’s craziest characters and wittiest rhymes, this brilliant board book explores numbers from 1 to 10!Bright, vibrant and with interactive flaps throughout, the Flip-the-Flap books are brilliantly designed for introducing early concepts to babies and toddlers and offer a perfect first step into the wonderfully wacky world of Dr. Seuss.

A funny flip-the-flap book for babies and young children, from the world of classic Dr. Seuss!An introduction to a variety of senses and the world of Dr. Seuss, perfect for babies and toddlers!Flip the flap – what can you see? Full of Dr. Seuss’s craziest characters and wittiest rhymes, this brilliant board book explores the world of the senses.Bright, vibrant and with interactive flaps throughout, the Flip-the-Flap books are brilliantly designed for introducing early concepts to babies and toddlers and offer a perfect first step into the wonderfully wacky world of Dr. Seuss.

A BIG nature book for sharing with a little person, introducing first words, colours, numbers, shapes, opposites and more - with felt flaps and a mirror!With bright, stylish artwork from Ingela P Arrhenius, illustrator of the internationally bestselling Felt Flaps and Peekaboo series, this BIG nature-themed playbook is perfect for sharing with older babies and toddlers. How many acorns can you count? What colour is the ladybird? What noise do the birds make? And finally, where are you?A brilliant large-format board book introducing early-learning first concepts and encouraging interactive play, with 10 soft felt flaps, tactile die-cuts on every page and a surprise mirror ending. Other titles available in the series: My BIG Playbook, My BIG Playbook: Farm

A BIG book for sharing with a little person, introducing first words, colours, numbers, farm animals and more - with felt flaps and a mirror!With bright, stylish artwork from Ingela P Arrhenius, illustrator of the internationally bestselling Felt Flaps and Peekaboo series, this BIG farm-themed playbook is perfect for sharing with older babies and toddlers. How many sheep can you count? What colour are the tomatoes? What noise do the farm animals make? And finally, where are you?A brilliant large-format board book introducing early-learning first concepts and encouraging interactive play, with 10 soft felt flaps, tactile die-cuts on every page and a surprise mirror ending. Other titles available in the series: My BIG Playbook

A beautifully illustrated series that grows with your baby.Baby's First Stories presents a unique blend of read-aloud stories and high-contrast visuals, featuring an adorable elephant, panda, whale and bunny. Each story has been created in consultation with Early Years Expert Lizzie Noble, to perfectly suit your baby's needs at every stage in their first year.9-12 months prompts older babies to interact with the book, tickling panda's tummy and looking for details in the artwork to reflect your baby's ability to spot fine details and respond to basic questions. Jane Foster's black-and-white artwork features bold pops of blue, red and yellow, including hidden details - reflecting your baby's sharpening eyesight.Neither too long, nor too short, each story will easily fit into baby's day, to make reading together a regular activity. Beautifully illustrated by award-winning textile designer Jane Foster, and written by picture book rising-star, Lily Murray.

Learn over 250 simple first words and discover amazing objects from the British Museum's collection with this stunning board book. Build your child's vocabulary with this unique board of first words. The sturdy tabbed pages make page turns easy, while the gorgeous images and objects will capture the imagination of curious toddlers.Equally curious adults can find out more about every object featured online using a handy QR code. This Nosy Crow book comes with a free 'Stories Aloud' audio recording - just scan the QR code and listen along!

A BIG book for sharing with a little person, introducing first words, colours, numbers, shapes and more - with felt flaps and a mirror!With bright, stylish artwork from Ingela P Arrhenius, illustrator of the internationally bestselling Felt Flaps and Peekaboo series, this BIG playbook is perfect for sharing with older babies and toddlers. How many ladybirds can you count? What colour are the strawberries? Where is the cat hiding? And finally, where are you?A brilliant large-format board book introducing early-learning first concepts and encouraging interactive play, with 10 soft felt flaps, tactile die-cuts on every page and a surprise mirror ending.

Baby Faces: Little Lamb, Where Are You? (附音檔QRCode)Baby Faces: Little Bear, Where Are You? (附音檔QRcode)Baby Faces: Little Dog, Where Are You? (附音檔QRcode)Find your baby’s face in this delightful new lift-the-flap book with a mirror on every page!One thing is for sure – babies love mirrors! This brand new series of board books aims to enhance early mirror play as very young children will enjoy finding their own face on every page. Featuring large card flaps with friendly animals which are easy for even the littlest hands to grab, babies will enjoy reaching for these books again and again.Scan the QR code on the back cover to join in with the playful rhyming song based on the classic ‘Finger Family’ rhyme!

描寫小獅子Lionel一心想成為像爸爸一樣的大人。他的每一個舉動都充滿模仿的童趣，也引發一連串既真實又逗趣的小混亂。書中以簡潔對話與溫柔情節，呈現孩子在成長過程中的探索與父親的包容回應。A warm father and son story in which an irresistible lion cub proudly tries to be just like Dad. Lionel can do everything Dad does: Dad combs his hair. So does Lionel. Dad scratches his arm. So does Lionel. Dad sings very, very loud. So does Lionel. But when Lionel throws all the toys in the air and they come down THUNK on Dad’s head … Dad yells! Ow! So does Lionel! Dad takes a break and has a think. Then comes rushing back for a big hug—Dad is very, very happy, and so is Lionel! Boundary-pushing Lionel has a mischievous grin that instantly wins us over, and his tolerant father incidentally provides a great model for parenting. This small and sturdy board book is just right for toddlers’ and preschoolers’ hands making it ideal to read alongside a child. Lionel Is Just Like Dad is the third book in this pithy board book series, designed to be read as standalone stories that introduce development

Turn the pages to discover the fire engines with their bumpy doors, squashy wheels and sparkly lights as they speed through the pages of this sturdy board book. Babies and toddlers will delight in the bold illustrations and touching the fuzzy, furry, smooth and soft fabric patches on each page. That's not my...books are designed to be shared and support sensory and language development. Don't forget to spot the familiar little white mouse on every page of this sturdy board book, perfect for little hands. DID YOU KNOW...? One That's not my...book is sold every minute in the UK! With over 60 titles to choose from, there's a That's not my... book for everyone.

Join best friends Bear and Mouse as they have a farmyard adventure! From a friendly farmer in his tractor and a hungry horse to a mummy pig and her babies, there are so many exciting things to see!Clever slider mechanisms and lift-the-flaps encourage your little one to interact with the book and learn about the animals which they might find on the farm. A gentle and engaging introduction to a popular early-learning concept. Also available: Bear and Mouse Start the Day, Bear and Mouse Go to Bed, Bear and Mouse Birthday Party, Bear and Mouse NurseryComing soon: Bear and Mouse at the Park

A brilliantly witty introduction to comparisons and opposites, illustrated by the winner of the Sainsbury’s Children’s Book Award.These children and animals are all very different to each other. Some are big, some are small. Some are gentle, some are rough. Everyone is playful, but who’s the best at hiding? One thing’s certain: they all love a good bedtime story!Shortlisted for the Sainsbury’s Children’s Picture Book Award, this is the perfect book for little ones who are just beginning to make sense of their place in the world. Karl Newson has created a simple, funny and heart-warming text, which is perfectly matched by Kate Hindley’s charming, brilliantly witty artwork, filled with detail.Every Nosy Crow paperback picture book comes with a free “Stories Aloud” audio recording. Just scan the QR code and listen along!Related activity sheets available on the Nosy Crow website."Newson and Hindley celebrate differences using simple but wonderfully effective opposites and comparisons, with

Discover the celebration of Christmas with this bright, interactive lift-the-flap book. Lift the flaps to reveal the Christmas tree, greet the carol singers and open presents!Featuring simple text, gorgeous illustrations and satisfying lift-the-flaps, this book explores common Christmas traditions and helps young children understand the importance of this special holiday. The First Festivals series invites children to explore the world's culture from the comfort of their home, encourages the development of hand-eye coordination and is recommended for children aged 2 and over.

《忙碌小熊》挑戰新職業！進入動物醫院，用簡單重複的文句，認識獸醫的工作。連結QR-Code音檔，動動小手操作機關，化身獸醫幫助忙碌小熊一起照顧動物們吧！ Five easy-to-use sliders, a rhyming story and lots to spot and say in this series of bright, interactive board books for toddlers!Join Bizzy Bear as he looks after the animals at the vet’s clinic! Little ones will love using the chunky sliders to help Bizzy Bear X-ray the dog’s paw and wrap a bandage around it, then see who else is in the waiting room today! Another exciting title in this best-selling series which encourages preschoolers to get involved in the storytelling.This story needs YOU! By pushing, pulling and turning the mechanisms, little hands can move the story onto the next scene and bring the rhyming text to life! The high level of interaction builds confidence and engagement with books, which is a key stepping-stone to reading for toddlers.Illustrated by multi-award-winning Benji Davies, illustrator of The Storm Whale, and Grandad’s IslandCollect the whole series; other title available include:

Find out about all kinds of weird, wonderful and utterly fascinating dinosaurs, with this set of four jigsaws and an early-years book. The simple four-piece puzzles are ideal for infants and toddlers making for a fun and engaging learning experience. Elisa Ferro's delightful illustrations and an accompanying picture book make this perfect for play or quiet reading time.

A bright and adorable tabbed board book featuring first words all to do with a day in town, from a trip to the library, to shopping, to the park, to lunch at a cafe and more! Join Maisy for a day trip to her local town. Each spread is themed around different shops and locations: the library, the post office, the garden centre, the supermarket, a cafe and more! With bright, colourful, clearly labelled pictures to help broaden vocabulary and understanding, and bold, easy-to-use tabs which are perfect for helping little ones to locate their favourite pages again and again. Early learning is so much fun!

A bright, fun first concepts book featuring sweet mice characters and simple, yet clever die-cuts, Little Mouse Learns: SHAPES explains the concept of shapes to young children.A bright, fun first concepts book featuring sweet mice characters and simple, yet clever die-cuts to explain the concept of shapes. In this innovative die-cut title, children will learn the concept of shapes through bright, fun illustrations featuring Little Mouse and other friendly animal characters.The peep-through holes help children engage with the title and encourage sensory development and exploration, and bold colours bring these books to life.This is the first title in a series of first concept books in the Little Mouse Learns series:Book 1: OPPOSITESBook 2: COLOURSBook 3: SHAPESBook 4: NUMBERS​These board books are great for young children as they introduce them to these basic but important concepts in a friendly, fun, and accesible way!

疫情肆虐，勤洗手成為建立良好衛生習慣的第一步。Big Steps幼兒生活教育操作書，以外出回家後要洗手等情境帶領孩子邊玩邊學習清潔的重要性，也提供家長教學小要點。The Big Steps series is designed to help little ones cope with everyday experiences in their lives. In Let's Wash Our Hands, meet two adorable toddlers who learn all about washing their hands and bath time!Follow the ups and downs of their journey, brought to life with fun flaps and mechanisms. Each page has really helpful tips for parents and carers that are endorsed by The Good Toy Guide and leading Early Years Consultant, Dr Amanda Gummer. With delightful illustrations from Marie Kyprianou, Let's Wash Our Hands is a brilliant way to introduce cleanliness in a fun and relatable way.For more toddler tips read No More Nappies, No More Dummies and I'm Starting Nursery.The Big Steps series has been endorsed and recommended by Dr Amanda Gummer's Good Toy Guide.

Celebrate forty years with this special edition of Rod Campbell's classic lift-the-flap book, Dear Zoo, with a host of favourite zoo animals and flaps to lift on every page. 'I wrote to the zoo to send me a pet . ..'Young children will love lifting the flaps to discover the animals the zoo has sent - a monkey, a lion and even an elephant! But will they ever manage to send the perfect pet?Rod Campbell, the creator of preschool favourites including Oh Dear! and Noisy Farm, has been a trusted name in early learning for over forty years, and the perennial classic, Dear Zoo has been a firm favourite with toddlers and parents alike since its first publication in 1982. With bright, bold artwork, a catchy refrain and a whole host of favourite animals, Dear Zoo: 40th Anniversary Edition is a must for every child's bookshelf, and the thick card pages, chunky cased cover and sturdy flaps make it perfect for small hands. Look out for Rod Campbell's Look After Us, a lift-the-flap animal book for to

Learn all the super-important skills you need to keep healthy with this new series of books all about early life skills.No matter what grown-ups tell you, being little is hard work; there’s so much to

《忙碌小熊》冬季新書，推一推幫小熊登上纜車，滑雪去！幼兒也能輕鬆操作的推拉機關，伴隨QR-Code音檔中清晰的英國腔念出重複的韻律，讓忙碌小熊躍於紙上，拉近孩子與書的距離。Five easy-to-use sliders, a rhyming story and lots to spot and say in this series of bright, interactive board books for toddlers!Join Bizzy Bear and friends as they take a winter trip into the mountains! Little ones will love using the chunky sliders to help Bizzy go up in the ski lift, then zoom down the mountain again – and end the day with a spin around the ice-skating rink! Another exciting title in this best-selling series which encourages preschoolers to get involved in the storytelling.This story needs YOU! By pushing, pulling and turning the mechanisms, little hands can move the story onto the next scene and bring the rhyming text to life! The high level of interaction builds confidence and engagement with books, which is a key stepping-stone to reading for toddlers.Illustrated by multi-award-winning Benji Davies, illustrator of The Storm Whale, and Grandad’s IslandCollect the whole series; o

This innovative board book uses fingertrails with sliding discs to introduce young children to early learning concepts and the world around them. Young readers can look at the bold scenes, listen to t

A charming series filled with clever paper engineering techniques. These bright pictures move and change with the turn of every page, engaging young readers and bringing early learning concepts to lif

A charming series filled with clever paper engineering techniques. These bright pictures move and change with the turn of every page, engaging young readers and bringing early learning concepts to lif

A charming series filled with clever paper engineering techniques. These bright pictures move and change with the turn of every page, engaging young readers and bringing early learning concepts to lif

Scholastic Early Learners: Learn your ABCs with this interactive book, which guides readers through the alphabet with interactive sliders. Includes a QR link to the alphabet song!Learn to sing your AB

A sturdy, stylish board book, designed as a companion to Mindful Tots: Tummy Ride, introduces the smallest children to a mindfulness practice designed to manage early emotions and nurture compassion t

「去看醫生了喔！」這句話不再讓孩子焦慮。跟著Billy和Nell一起檢查身體、打預防針，透過小機關翻頁認識醫院。書中設計充滿巧思，每一頁都有互動樂趣與實用小叮嚀，幫助家長在故事中和孩子建立安全感。The Big Steps series is designed to help young children deal with new experiences in their lives. In We're Going to the Doctor, Billy and Nell go for a check-up and have an injection. This novelty book with a sweet story has fun flaps to lift and mechanisms to move as well as practical tips for parents and carers on each page, endorsed by leading Early Years Consultant, Dr Amanda Gummer.With delightful illustrations by Marion Cocklico, We're Going to the Doctor is the perfect book for sharing and reassuring little people.For more toddler tips, read We're Having A Baby, I'm Not Sleepy, No More Nappies, I'm Starting Nursery and Can You Say Please?

If you can see it, you can be it! Introduce your child to your role models with this series of inspirational board books.It's never too early to introduce your child to the people you admire! This boa

A new novelty board book series aimed at children from birth, the series uses moving tabs or flpas on all 5 spreads as well as the cover to introduce children to early learning concepts (sea

BabyLit® Storybooks give classics new life for the next generation of early readers.In Pride & Prejudice, children are invited into the Regency period to meet the Bennet sisters, Mr. Darcy, Mr. Bingle