Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Talk-About-Books feature a simple text and engaging photographs intended to encourage discussion and the development of literacy.

Packed with first words and colourful illustrations, this little board book is perfect for encouraging early readers.For readers aged: 0+

I have a tiny reindeer. He says his name is Bob. The winsome tale of Bob opens this book of seven Boynton Christmas stories. Using the colorful picture tabs, little children can choose the story they

In this simple adaptation of Michael Frith's classic Bright & Early Book?, I'll Teach My Dog 100 Words, a pet owner doesn't just teach basics like beg and bark, but also such unlikely canine comma

A classic silly song that toddlers know and love, Down by the Bay has been a favorite and best-selling Raffi Songs to Read/reg/ since it was first published in 1988. In this friendly board book edition, irresistible art by Nadine Bernard Westcott depicts wonderfully amusing creatures such as a bear combing his hair, a goose kissing a moose, and a whale with a polka-dot tail. Very young children will find this book both entertaining and instructive in early language skills such as rhyme, rhythm, and repetition, and will delight in hearing it read or sung aloud to them.

An age-appropriate board book, adapted from Curious George's original adventures, finds the clever monkey using his newfound language skills to get an abundance of doughnuts.

Talk-About-Books feature a simple text and engaging photographs intended to encourage discussion and the development of literacy.

Share these animals and their babies with your baby. It is never to early to look and talk together!

Talk-About-Books feature a simple text and engaging photographs intended to encourage discussion and the development of literacy.

Talk-About-Books feature a simple text and engaging photographs intended to encourage discussion and the development of literacy.

What happens when a car meets an obstacle it can't cross? Engineering, of course! This book of block building fun will encourage readers to build early STEAM skills.

Join Bluey and Bingo in this interactive Keepy Uppy push-and-pull book!Bluey, Bingo and Mum play Keepy Uppy around the house but when Dad joins the game, it gets very competitive. Can Bluey and Bingo keep their last balloon from touching the ground? Join in the fun and push and pull the tabs to join their game of Keepy Uppy!“You have to keep the balloon in the air, and you can’t let it touch the ground.”Join Bluey and Bingo in this interactive Keepy Uppy push-and-pull book!Don’t miss these other awesome Bluey books:Bluey: Bluey and Bingo’s Book of Bugs: A Push-and-Pull Board BookBluey: Outdoor Games: A Lift-the-Flap BookBluey: A Big Pop-Up BookBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Jo

When you add water to the black and white pictures in this book using the brush included, the world below the waves fills with beautiful colours. Once the water dries, the colour magically vanishes... so you can keep painting it and bringing the colours back. From clownfish and squid to sharks and whales, the sturdy board pages are always waiting for you to fill them with colour again.- Chunky board book with6 reusable double-page spreads-Just add waterto bring the black and white pictures magically to life- Let it dry and the colours disappear to enjoy itall over again- Idealmess-free, on the go activity- Suitable for age3 years and up

A shapes adventure you WON'T want to miss from Mo Willems Workshop.The Pigeon won't play with shapes, and here's why:Circles. They're pointless.Triangles. Too pointy.Squares? Boring.Rectangle? Long and boring.Do YOU think The Pigeon will play with shapes?From Mo Willems Workshop comes this funny and engaging early-learning concept board book all about shapes, with touch-and-trace features throughout. The Pigeon WON'T Play With Shapes! is part of a collection of original board books featuring The Pigeon, ideal for babies, toddlers, and fans of the picture book series.

A shapes adventure you WON’T want to miss from Mo Willems Workshop. The Pigeon won't play with shapes, and here’s why: Circles. They're pointless. Triangles. Too pointy. Squares? Boring. Rectangle? Long and boring. Do YOU think The Pigeon will play with shapes?From Mo Willems Workshop comes this funny and engaging early-learning concept board book all about shapes, with touch-and-trace features throughout. The Pigeon WON'T Play With Shapes! is part of a collection of original board books featuring The Pigeon, ideal for babies, toddlers, and fans of the picture book series.

A BIG book for sharing with a little person, introducing animals, first words, colours, numbers and more - with felt flaps and a mirror!With bright, stylish artwork from Ingela P Arrhenius, illustrator of the internationally bestselling Felt Flaps and Peekaboo series, this BIG animal-themed playbook is perfect for sharing with older babies and toddlers. How many zebras can you count? What colour is the crocodile? What noise does a frog make? And finally, where are you?Includes a FREE Nosy Crow Stories Aloud® audiobook! Scan the code, hear the story.A brilliant large-format board book introducing early-learning first concepts and encouraging interactive play, with 10 soft felt flaps, tactile die-cuts on every page and a surprise mirror ending.Other titles available in the series:*My BIG Playbook*My BIG Playbook: Farm*My BIG Playbook: Nature*My BIG Playbook: Things That Go*My BIG Playbook: Christmas

Celebrate the 250th anniversary of American Independence with this very special ABC book that's perfect for toddlers and preschoolers!Each letter of this illustrated alphabet has been paired with something from American culture or geography, featuring everything from apple pie to the White House.Beautifully illustrated by the bestselling Ingela P Arrhenius, each letter is clearly labelled to encourage early learning and to help preschoolers grasp the very first foundations of reading.Includes a FREE Nosy Crow Stories Aloud® audiobook! Scan the code, hear the story.This book will help young children to learn about the unique sights and symbols that make the United States such a special place!

Visit Grandad with Bluey and Bingo!Bluey and Bingo are visiting Grandad but instead of resting like he’s supposed to, he takes them on adventure into the bush. They run, hide and even canoe to escape a worried Mum. Can Mum catch them?“Aren’t you meant to be resting, Grandad?”“You have to catch me first!”Join the chase in this brilliant board book!Don’t miss these other awesome Bluey books:Bluey: The WeekendBluey: Hide and SeekBluey: Granny MobileBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

You'd better not tickle that duck... because it might just quack if you do!Each time you tickle one of the soft patches in this book, you'll hear a sound effect. As well as the duck, there's a goose, a swan and an owl to tickle... until all the bird friends get together for a big dance to some toe-tapping music at the end!With over 30 books to discover in this award-winning series, there is a book to excite every baby and toddler; including dinosaurs, bears, tigers, unicorns and lots more - giggles are guaranteed!Every DON'T TICKLE book supports sensory development with:- Engaging characters to encourage playfulness- Furry patches for developing motor skills- Playful music to inspire movement- Holes to peek through, sparking curiosity- Rhythmic text for developing language

Where is Bear? Is he hiding behind the fridge? Is he hiding under the sofa? Is he in the bathtub? Search for Bear and learn new words as children explore familiar spots around the house in this gorgeous lift-the-flap book.Bear loves to play hide-and-seek! Can you find him? Lift each flap to discover where Bear is hiding around the house. Is he behind the kitchen door, under the sofa or in the bathtub? What other animals will you meet along the way?With adorable artwork and a clever cat who knows Bear's secrets, Where is Bear? is the perfect first book of prepositions for little ones. The playful text encourages early learning of prepositions and first words, while the interactive flaps spark curiosity and joy.From the celebrated author of Our Love comes an adorable new pre-school range exploring first concepts.

An alphabet adventure you WON’T want to miss, from Mo Willems Workshop!From Mo Willems Workshop, the team behind the #1 bestselling Don't Let the Pigeon Drive the Bus!, comes this hilarious and engaging alphabet early-learning concept board book with touch-and-trace features throughout.The Pigeon won't say the ABCs! He has at least 26 reasons and excuses why not! From absolutely no way to zero chance!The Pigeon WON'T Say the ABCs! is part of a collection of original board books featuring the beloved character: The Pigeon.Ideal for babies, toddlers, and fans of the picture book series.

A series of board books to help toddlers develop from first words to first phrases by introducing simple word combinations and first experiences.Let's go down to the Muddy Farm! with four toddlers and their families and spend the day with the animals. Arrive at the farm ("so exciting!"), see the animals ("fluffy chicks"), have a snack ("crunchy apple"), then take a ride on a tractor ("so bumpy!").With text written in consultation with Priya Desai, a children's speech and language therapist, Toddler Talk features familiar scenes of everyday life with lots of busy toddlers to look at (including a mirror on the final page so they can see themselves). Read along with your toddler to build the next step in their language development - putting single words together to create everyday phrases.Also available in the series:Toddler Talk: Let's Go!Toddler Talk: All Gone!Toddler Talk: My Potty!

Join Brown Bear and Friends as they celebrate love and the power of hugs!Hugs when you're happy.Hugs when you're sad.Hugs when you're scared.Hugs when you're mad!Join Brown Bear and Friends as they celebrate love and the power of hugs!This charming, sweet rhyming book is the perfect gift for Valentine's Day - or any day of the year.Fans of Eric Carle will love this special hug in a book as it’s the perfect way to say I love you. Using a range of images from the World of Eric Carle, and featuring Brown Bear, Polar Bear, Panda Bear, Baby Bear and more, this special gift book celebrates the affirming power of a hug.Want to read more from Brown Bear and friends, check out:Brown Bear, Brown Bear, What Do You See?Baby Bear's Busy DayBrown Bear: 123Brown Bear: Colours

Celebrate all things lucky with The Very Hungry Caterpillar!Using a range of colorful images from the World of Eric Carle and featuring The Very Hungry Caterpillar, this charming board book showcases different examples of luck, from four-leaf clovers to rainbows and more. The perfect gift to celebrate St. Patrick’s Day!

Join Bluey and Bingo as they play games at the weekend.It’s the weekend! What games will Bluey and Bingo play? Join them and discover what happens when Dad buys a statue that is definitely not a magic statue and meet Bingo’s new bug friend!“You sold me a magic statue!”“Give me back my dollar-ee-doos!”This board book will keep little ones entertained at the weekend!Don’t miss these other awesome Bluey books:Bluey: Granny MobileBluey: BBQBluey: Daddy RobotBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

A hilarious new Bluey story that comes with a soft and cuddly puppet built into the book!Follow the story and play along with the Unicorse puppet to bring this Bluey story to life. Unicorse is a grub but he wants to marry Mum. Can Bluey and Bingo help clean him up?Use your puppet to act out cleaning Unicorse's teeth, taking a shower, and brushing his hair.This interactive hand puppet book is perfect for a fun and lively story time. “OK, let’s do this!”Don’t miss these other awesome Bluey books:Bluey: Bluey’s Pop-Up BookBluey: Toys: A Touch-and-Feel PlaybookBluey: A Jigsaw Puzzle BookBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK.Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty

跟著Bluey一家高唱他們獨特的聖誕歌！從「Bandit smells」到「Bluey ran away」，熟悉的旋律變成滿滿笑料。這本小巧厚紙板書色彩明亮、節奏輕快，是孩子聖誕襪裡最可愛的驚喜。Bluey以她的想像力和幽默感，把家庭日常化為歡樂冒險，讓節慶時光更加熱鬧。Sing Jingle Bells with the Heeler family in this hilarious Bluey version of a Christmas classic!“Jingle bells, Bandit smells, Bluey ran away!”This Bluey board book is the perfect stocking filler for little ones and will get everyone in the festive mood this Christmas. Don’t miss these other awesome Bluey books:Bluey: Let’s Play Verandah Santa: A Lift-the-Flap Book Bluey: Christmas SwimBluey: Bluey’s Night Before ChristmasBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK.Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun?collection of story, activity and novelty books that celebrate play.

Use the 'magic torch' to help Spot find lots of hidden animals on his bedtime walk!Spot and his family are camping in the garden, and it's nearly time for bed - but he's not tired! Join him on his bedtime walk and see how many animals you can discover along the way. Insert the ' magic torch' between the pages to bring each night-time scene to life and reveal the animals hidden behind clever windows on each spread. Eric Hill's Where's Spot? was the first ever lift-the-flap book - and his ground-breaking innovation continues to delight and surprise readers with interactive fun.Spot has now been a trusted character in early learning for over 40 years, selling over 65 million books worldwide. Loved this? Try these other Spot stories:Where's Spot?Spot Says GoodnightSpot's Goodnight StarsFind Spot at the NurserySpot's Slide and Seek: FarmSpot's Nature Fun

Find Rosie Reindeer and her cuddly friends hiding behind flaps and popping up from the pages in this delightful book for little ones. Rosie Reindeer wants to go outside to play in the snow. But who can she find to join her and where is her sledge? Babies and toddlers will love lifting the big flaps to play peekaboo with Parker Polar Bear, Peter Penguin, Harry Husky, and Sophie Seal as they get ready to have fun in the snow. Rosie Reindeer finds each of her friends, she wraps up warm, puts on her favorite red wellies, and goes outside. Now it's time for Rosie Reindeer's friends to find her! The lively, read-aloud rhymes in this book encourage literacy and early learning, while the surprise pop-up characters will delight curious preschoolers. With the help of parents or caregivers, toddlers will have fun turning the sturdy board book pages and lifting the flaps to find Rosie Reindeer and her cuddly winter friends. Ideal for interactive preschool play, Pop-up Peekaboo! Reindeer will appea

Bluey, Bingo and Muffin are playing Granny Mobile at Doreen’s garage sale. Muffin is a grouchy granny and ordering Dad to push her on an old mobility scooter. But will Muffin budge when a real grouchy granny tries to buy her scooter?“I think you should mind your own business!”That is one grouchy granny .. . Don’t miss these other awesome Bluey books:Bluey: BBQBluey: The DoctorBluey: Road TripBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family.It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

Delight your little one with five pop-up surprises featuring Toy Story characters in this delightful board book!It?s playtime with the Toy Story pals! Join Woody, Bo Peep, Buzz Lightyear, Jessie, and their friends in this pop-up and flaps board book for curious little ones who love Toy Story and Disney and Pixar movies. Little hands can lift big flaps and see five peekaboo surprises pop up from the pages, and explore themes of friendship, teamwork and bravery. This interactive pop-up book for 0-3 year olds includes:Hands-on play elements that build all-round learning skills.Lift the 5 flaps throughout the book to find the pop-ups, helping to develop fine motor skills. Rhythmic, read-aloud text that aids language development. Rounded edges and chunky board book pages rigorously tested (and chewed) by toddlers.Ideal for interactive preschool play, Pop-Up Peekaboo! Disney and Pixar Toy Story will appeal to both parents and children and is certain to keep little ones entertained time and t

Miffy’s world is so colorful! Come along to explore blue things that go, green things at the pond, yummy orange things, and more! Which color is miffy’s favorite? All of them, of course! Your little one will love wiggling the sweet, plush Miffy finger puppet as they follow along on her color adventure. Featuring the beloved original artwork of miffy creator, Dick Bruna.Look for other miffy books from Cottage Door Press, including good night, miffy, flowers for mother bunny, and a surprise for father bunny!*The adorable built-in finger-puppet encourages interactive finger play, which helps develop little muscles and build finger strength, improving coordination and fine motor skills. *Soft plush provides tactile learning opportunities for babies and toddlers.*Thick board pages perfect for little hands to actively participate in storytime. *Charming illustrations by Dick Bruna will capture the attention of early readers with simple shapes and bold, primary colors.*Littles learn best when

This fun baby book allows young children to practise their foundational literacy and hand-eye coordination skills while being introduced to the different types of landscape on planet Earth, from deserts filled with cacti to count to cities with bright windows. With warm, inviting illustrations and text encouraging them to spot and find different features on the page, this book will soothe and focus the attention of young children. Talking about the pictures helps to familiarise babies with patterns of speech.Talking and listening go together and help lay the foundations for language development.

Bluey and Bingo are playing with their favourite toys. Join them and play along! Stroke Polly Puppy’s soft fur, feel Sticky Gecko’s sticky skin and admire Unicorse’s shiny horn. This touch and feel book is perfect for Bluey fans who love to play!Don’t miss these other awesome Bluey books:Bluey: Meet Bluey’s Family: Tabbed bookBluey: A Jigsaw Puzzle BookBluey: Big Box of Little BooksBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family.It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

Jump-start your preschooler's exposure to vocabulary and sports using this adorable book featuring 100+ foundational words from your favorite sports! Designed by a professional watercolor artist and licensed speech therapist, Our Big Book of Sports includes charming watercolor illustrations and foundational first words that will help you build your child's vocabulary. The durable materials and small book size also make them perfect for your baby's little hands. Our Big Book of Sports features 100+ foundational words for the following sports: BaseballBasketball American FootballSoccer Hockey Tennis Pickleball Bowling Swimming Track & FieldThe back of this first words book also includes a "seek and find" activity to help parents encourage their little ones to learn to identify the pictures on the page. Created by speech therapist Tabitha Paige, MS, CCC-SLP, author of the best-selling series Our Little Adventures, this first words book features functional language and a timeless desig

Gorgeous illustrated board book about all the amazing things a toddler can do!The Wow! board books are a series of modern first concept books for today's children. The books put little ones in the centre of the action with relatable experiences that will help foster discussion, inclusivity, and empathy. Illustrated by Alberta Torres, illustrator of This Little picture book series.Wow! Look at Me! celebrates all the amazing things a three-year-old can do, such as learning to ride a tricycle, discovering how to be a good friend, counting to ten and back again, and using the loo for the first time, among other mini wins. Centred around a group of four friends and their daily routines and experiences, toddlers will love seeing how their own lives relate and differ. This fun, vibrantly illustrated book comes with fun sounds to repeat in each scene.

Miffy wants to surprise her father with a gift. What will she give him? Read how miffy and her dad spend time together — and see what gift she decides to make for him. Featuring the original artwork of miffy creator, Dick Bruna, with sturdy, shaped pages, perfect for children to read and play with over and over again.Look for other miffy books from Cottage Door Press, including good night, miffy, colors with miffy, and flowers for mother bunny!*Charming illustrations by Dick Bruna will capture the attention of early readers with simple shapes and bold, primary colors. *Shaped board book with sturdy, thick pages that are perfectly sized for little hands and fingers to turn the pages and read along.*Collect all the fun shaped board books in this series from Cottage Door Press and strengthen a love for books & reading at the earliest ages.*Perfect book for your Father’s Day collection!

Miffy and mother bunny are taking a walk together. Learn about beautiful flowers and other things that grow with Miffy -- and see what lovely surprise she gives her mom. Featuring the original artwork of Miffy creator, Dick Bruna, look for other Miffy books from Cottage Door Press, including Good Night, Miffy, Colors with Miffy, and A Surprise for Father Bunny!Charming illustrations by Dick Bruna will capture the attention of early readers with simple shapes and bold, primary colors. Shaped board book with sturdy, thick pages that are perfectly sized for little hands and fingers to turn the pages and read along.Collect all the fun shaped board books in this series from Cottage Door Press and strengthen a love for books & reading at the earliest ages.Perfect book for your Mother's Day collection!

An interactive board book all about the farm! Packed with flaps and early-learning concepts including colours, numbers, opposites and more. Little farm enthusiasts will love the search-and-find games with lots to spot. The only farm book you'll ever need!

Learn amazing animal facts, and have fun spotting all of Elmer the patchwork elephant's friends in his colourful world!In this big and busy search and find board book adventure, learn amazing animal facts. Did you know that giraffes' tongues are black? Or that baby rabbits are called kittens? And crocodile mums carry their babies in their mouths? Jam-packed fun facts spotting activities, questions to answer and details to discover, all from Elmer’s colourful world. Featuring a maze with quiz questions to test their new knowledge at the end of the scenes, this book will help young children learn more about the natural world while developing their powers of observation, visual acuity, and their early numeracy and language skills as they go.Also in the Elmer Search and Find series:Elmer Search and FindElmer Search and Find ColoursElmer Search and Find Numbers