Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

From a New York Times bestselling author comes this poignant, lyrical tale about nature's great escape artist--now in a board book edition! The octopus is happy in his undersea cave until one day, a diver captures him and takes him to live in an aquarium. The humans give him food and tests that look like toys. But every day is the same, and the octopus soon tires of captive life. And so, under the cover of darkness, he makes his daring escape... Maile Meloy and Felicita Sala bring us a story full of excitement and heart, about the thrill of hard-won freedom and the pull of home.

Dog is ready for bed, but first he wants to say goodnight to all his farm animal friends in this magical bedtime story book.Young children will love to help Dog find his farm animal friends in this interactive novelty book. Insert the included 'magic torch' between the pages to find Dog's friends in each night-time scene and watch children glow with delight!

The Very Hungry Caterpillar is playing hide and seek in the jungle! Follow the finger trails and lift the flaps to discover sleeping sloths, swooping parrots, crawling tigers and many more. A gentle rhyming narrative with a die-cut finger trail, die-cut details and a chunky flap on every page. There is so much for little hands to explore in this fun first introduction to jungle creatures and their habitat.

The original, award-winning Felt Flap series - perfect for babies and toddlers!Each title in this stylish series has five spreads with friendly characters to find behind colourful felt flaps. In Where's Mr King?, you're on the look out for Mrs Tube Driver, Mr Beefeater, Mrs Cyclist and Mr King himself!Lift the final flap and there's a surprise mirror - always a hit with the little ones. Parents adore these books because they are beautiful but tough enough to withstand even the most enthusiastic of young readers.And children love them because they are just so much fun. Other titles in the series include, Felt Flaps Where's Mr Lion?, Felt Flaps Where's Mr Unicorn? and Felt Flaps Where's Mrs Ladybird? Felt Flaps Where's Mr Lion? won Sainsbury's Children's Book of the Year 2017The felt flaps in this sturdy board book are perfect for little ones to turn and tug, which means you can get even the tiniest tot into books and finding the activity fun. Ingela Arrhenius' illustrations are a real b

Join in and help the busy police officer in this playful, interactive flap book!Can you help the busy police officer to find the robber? Join in and use the flaps to investigate the robbery, fly the police helicopter, and follow the trail with the help of Ted the dog. With interactive action-flaps, you can do it, too!Each clever flap provides an action or scene-change to encourage children to actively engage and explore. The playful flaps are perfect for little hands to develop fine motor skills and hand-eye coordination.Original concept and illustration by Dan Green.

Learn all about insects in this buzz-worthy addition to the bestselling Abrams Block Book series In this follow-up to Alphablock, Countablock, Dinoblock, Cityblock, Buildablock, Farmblock, Loveblock, Sharkblock, and Spaceblock, readers will learn about all the things that make bugs incredible--from spider crickets that can jump 60 times their own length to Chinese stick insects that can grow to be over two feet long to caterpillars that transform into stunning butterflies. In keeping with the rest of the series, Bugblock features the charming art of British design team Peski Studio, pages with die-cuts readers can peek through, and special flaps that unfold to reveal hidden details.

You'd better not tickle the gorilla, because it might just grunt if you do! Babies and toddlers will love pressing the touchy-feely patches to hear the animal sounds in this irresistible novelty book. At the end, all of the animals get noisy at the same time in a musical finale guaranteed to get everyone dancing.

There's so much happening in springtime! As the days get warmer, leaves grow and flowers pop up, and all the animals get busy. Peep under blossom, behind the meadow flowers and into the pond to find nests full of chicks, baby bunnies, wiggly tadpoles, and other animals bustling round in spring. This bright interactive book will absorb little children while discovering what goes on in this lovely season.

Explore the big outdoors in these action-packed animal board books with sliders on every page.Published in collaboration with theNational Trust, this brand new series of board books will inspire a love of nature in even the littlest of animal lovers. With vibrant artwork printed on white board, robust easy-to-use mechanisms for tiny hands and a rhyming text with friendly animal facts, these are the perfect books to captivate curious little explorers time and time again.In this first farm book, there are cows hiding in the barn, lambs playing in the field, ducks paddling near the pond and many more farm animals to bring to life with the moving parts.

A nature-based title in this prize-winning lift-the-flap series With bold, easy-to-lift card flaps, this stylish first words book is full of objects for children to recognize in nature. Every word is brought to life with charming artwork by home-ware designer Edward Underwood. And with flaps to lift on every page, little ones will enjoy exploring this book over and over.

Help the baby animals find their way home in this fun new sliding counter series!Meet rabbit, fox, bear and owl - four adorable baby animals who are lost in the woods! With easy-to-use moving parts and four unique tracks to develop hand-eye coordination and concentration, babies and toddlers will enjoy taking the baby animals home in this robust, satisfying board book. Scan the Stories Aloud QR code on the back cover to read along with the story!Other titles in the series include: Let's Go Home, Baby Tiger

Help the baby animals find their way home in this fun new sliding counter series!Meet tiger, parrot, elephant and crocodile - four adorable baby animals who are lost in the jungle! With easy-to-use moving parts and four unique tracks to develop hand-eye coordination and concentration, babies and toddlers will enjoy taking the baby animals home in this robust, satisfying board book. Scan the Stories Aloud QR code on the back cover to read along with the story!Other titles in the series include: Let's Go Home, Baby Rabbit

Have you ever wondered what it feels like to be in an earthquake, or close to a volcano with it erupts? With lots of flaps to lift, this book takes you on a tour of shaking cities and rumbling volcanoes to discover why these forces happen, how they shape our planet, and how people live in places where they strike.

Make your own 3D decorations with this brilliant board book of press-out chinese zodiac animals from the British Museum!From tigers to monkeys and horses to dragons, this book features 25 unique, intricately foiled designs that can be slotted together to create 3D ornaments, hung up or threaded together to make an amazing garland. Each page is covered in shiny red foil, with foiled pieces which can be pressed out and coloured in to make a fun collection of personalised animals.Other titles in this fantastic series include:Birds, Easter Eggs, Butterflies, Unicorns, Christmas Decorations, Halloween, Flamingos, Llamas and Other Cool Things, Narwhals and Mermaids, Ancient Egypt, Dinosaurs, and Fantastic Creatures.

A bright and bold novelty format with a different slide and pull tab on every spread.It's a beautiful day in Moominvalley and Moomin is going on an adventure! He is determined to find his best friend Snufkin. Could he be hiding up in the trees, or down by the lake, or inside a very dark cave?Help Moomin explore the great outdoors in this delightful and interactive board book.Discover more Moomin adventures:The Very BIG Moominhouse Lift-the-Flap BookMoomin and the Windy DayMoomin's Pancake Picnic Peep-InsideMoomin's Seek and Find Finger-Trail BookMoomin's Touch and Feel Playbook

Celebrate friendship with your favorite Pixar pals―including Woody and Buzz Lightyear―in the next book in the bestselling Abrams Block Book seriesFeaturing characters from every Pixar franchise―such as Woody and Buzz in Toy Story, Mike and Sully in Monsters, Inc., and Mei and her besties in Turning Red―Pixar Buddy Block shines a light on all the things that make friendship so special! Each spread showcases favorite Pixar moments alongside a bouncy, rhyming text, making this book perfect for the youngest fans as well as seasoned collectors. As with previous Block Book titles, this book will include die-cut pages, gatefolds, and the stylish art of Peski Studio.

Celebrate the World Cup with this lift-the-flap football book. Join in to help the footballer bring the trophy home!Ready, shoot . .. SCORE! Can you help the busy footballer to win the match? Join in and use the flaps to pass the ball, tackle the player, and shoot for the goal. With interactive action-flaps, you can do it, too!Each clever flap provides an action or scene-change to encourage children to actively engage and explore.The playful flaps are perfect for little hands to develop fine motor skills and hand-eye coordination.Original concept and illustration by Dan Green. Recommended for children aged 2+Also available in the Busy Day series: Astronaut Athlete Builder Chef Farmer Firefighter Footballer Train Driver Vet

Look for the major motion picture Lyle, Lyle, Crocodile, inspired by the beloved children’s books by Bernard Waber.When the Primm family moves to New York City and into the house on East 88th Street, they are surprised to find a crocodile living in their attic. But Lyle isn’t a regular crocodile—he’s playful, and friendly, and he can sing! Sing along with Lyle, Lyle, Crocodile in this board book.

Jorg Muhle小兔子互動硬頁書。可愛溫馨的睡前晚安故事，簡單圖文卻充滿吸引力，讓小寶貝不經意想要跟著小兔子一起躲進毛毯裡，大玩躲貓貓，不知不覺進入夢鄉。Join in with Little Rabbit, playing all the games that toddlers love in this new board book in the internationally bestselling Tickle My Ears interactive series that will have toddlers, adults and rabbits all playing together.Little Rabbit wants to play. He hides behind a blanket, then peeks out: Peek-a-boo! He splashes in the bath, swings back and forth, and plays with his own little rabbit too—one, two, three, whee, rabbit flies!Young children will love taking part in these familiar sequences and laugh at the cheeky finish, because Little Rabbit has grown up enough to play a joke on his readers.Jorg Muhle’s warm and accessible illustrations encourage children to take on all the roles in the story as they copy Little Rabbit. This new book in the bestselling interactive board book series will have toddlers jumping to play.Follow-on from Tickle My Ears: “A wonderful interactive bedtime book for children and l

Once teeming with plants and animals, our ocean is no longer in good shape. It's warming up and becoming a dumping ground for plastic rubbish. But it doesn't have to be that way! There are all sorts of clever things that we can do to make life in the ocean healthy again.

A series of chunky board books featuring things that go and sliding counters!Discover five different cars in this series of interactive board books with easy-to-use moving parts – a car, a sports car, a racecar, a four-wheel drive and a taxi!Learn vehicle vocabulary with simple first words, clear diagrams and helpful text prompts to encourage discussion. Then trace 5 types of transport around 5 different tracks with a moving counter on every spread and the cover. The perfect book for children who love racecars – and being in the driving seat!Other titles in the series include: Farm, Building Site and Trucks

It's time to snuggle down for a bedtime story with Elmer! In this chunky shaped board book, Elmer helps Baby Elephant find his lost teddy just in time for bed. Everybody needs their own special teddy bear at bedtime... have you got yours?A perfect introduction to the classicElmer and the Lost Teddystory for the very youngest readers, with an abridged text of the best-loved tale.

Explore the big outdoors in these action-packed animal board books with sliders on every page.Published in collaboration with the National Trust, this series of board books will inspire a love of nature in even the littlest of animal lovers. With vibrant artwork printed on white board, robust easy-to-use mechanisms for tiny hands and a rhyming text with friendly animal facts, these are the perfect books to captivate curious little explorers time and time again.In this first woodland book, there are shy deer to find hiding in the trees, a noisy woodpecker pecking on a tree trunk, moles digging holes and many more woodland creatures to bring to life with the moving parts.Other titles in the series include: Countryside, Seaside and River

The original, award-winning Felt Flap series - perfect for babies and toddlers!Each title in this stylish series has five spreads with friendly characters to find behind colourful felt flaps. In Where's Frida Kahlo?, you're on the look out for Pablo Picasso, Yayoi Kusama, Andy Warhol and Frida Kahlo herself!Lift the final flap and there's a surprise mirror - always a hit with the little ones. Parents adore these books because they are beautiful but tough enough to withstand even the most enthusiastic of young readers.And children love them because they are just so much fun. Other titles in the series include, Felt Flaps Where's Mr Lion?, Felt Flaps Where's Mr Unicorn? and Felt Flaps Where's Mrs Ladybird? Felt Flaps Where's Mr Lion? won Sainsbury's Children's Book of the Year 2017The felt flaps in this sturdy board book are perfect for little ones to turn and tug, which means you can get even the tiniest tot into books and finding the activity fun. Ingela Arrhenius' illustrations are a

Learn all about space in this out-of-this-world addition to the bestselling Block Book series!3 . . . 2 . . . 1 . . . Blast off! In this follow-up to Alphablock, Countablock, Dinoblock, Citybloc

Lift the flaps and join in the fun with Badger's Band, a new story in the bestselling Tales from Acorn Wood preschool series by Julia Donaldson and Axel Scheffler, creators of The Gruffalo. Badger wants to start a band and his friends are keen to join in the fun. Tortoise plays the trumpet and Bear can play piano, but who else wants to join the band? Lift the flaps to find out and join Badger and his friends for a special concert.With sturdy flaps on every spread and rhyming stories that are a joy to read aloud, Badger's Band joins the bestselling Tales from Acorn Wood which have been delighting parents and children for over twenty years. More lift-the-flap adventures from Acorn Wood: Cat's Cookbook, Squirrel's Snowman and Mole's Spectacles.

In this pithy board book series, an overenthusiastic, impulsive lion tests his daily routines to their limit—in Lionel Eats All By Himself, Lionel does just that, cheekily enjoying the remarkable mess that results.Lionel is in his highchair and insists on eating all by himself. His veggies—well done, Lionel! His soup—nice one, Lionel! But each bite leaves more and more mess in the room, and on Lionel. Watch out for the big burp to finish off before Dad helps Lionel down from the table.Cheeky toddler lion Lionel learns about looking after his own body. His mischievous grin puts the reader instantly on his side, and the tolerant voice of his father provides an amused commentary—and incidentally a lovely model for how to parent.

The original, award-winning Felt Flap series - perfect for babies and toddlers!Each title in this stylish series has five spreads with friendly characters to find behind colourful felt flaps. In Where's Mr Digger?, you're on the look out for Mrs Bulldozer, Mr Mixer, Mrs Tipper and Mr Digger himself!Lift the final flap and there's a surprise mirror - always a hit with the little ones. Parents adore these books because they are beautiful but tough enough to withstand even the most enthusiastic of young readers.And children love them because they are just so much fun. Other titles in the series include, Felt Flaps Where's Mr Lion?, Felt Flaps Where's Mr Unicorn? and Felt Flaps Where's Mrs Ladybird? Felt Flaps Where's Mr Lion? won Sainsbury's Children's Book of the Year 2017The felt flaps in this sturdy board book are perfect for little ones to turn and tug, which means you can get even the tiniest tot into books and finding the activity fun. Ingela Arrhenius' illustrations are a real bonu

Priddy Learning: My First ABC is an engaging novelty book with wheels to turn, specially designed to teach preschoolers the alphabet and first words.Preschoolers can learn the letters of this alphabet with this innovative wheel book. With two wheels to turn on every page, this sturdy board book has been designed to encourage children to interact with the activities as they learn their abc. Children can turn the wheels to find the correct picture that matches with the starting letter. The bright pictures and simple labels build early vocabulary, while the wheels help to develop hand-eye coordination.Part of the Priddy Learning series which also includes; Priddy Learning: Let's Spell; Priddy Learning: My First Animals; Priddy Learning: My First Ready for School; Priddy Learning: My First Clock Book, Priddy Learning: My First Wipe Clean ABC, Priddy Learning: My First Wipe Clean Pen Control, Priddy Learning: My First Wipe Clean Words, Priddy Learning: My First Wipe Clean Starting School, P

Join Bee on a trip through the meadow in search of the hive in this interactive adventure, filled with touch-and-feel textures, lift-the-flaps, and peek-through holes! Little ones will love to join Bee on an adventure through the meadow in search of the beehive. Bee sees some flowers, and children can lift the flap on each to see what's underneath. Bee then meets Caterpillar on a branch, where there are leaves to lift and peek under each. The next friend that Bee meets is Ladybug, who blends in with the mushrooms that children can peek under. Bee then sees Worm and finally Firefly, right before it's time for bed. With die-cut, touch-and-feel textures, peek-through holes, and lift-the-flaps throughout, this book is an interactive, tactile adventure!

Push, pull and slide the tabs to learn about looking after Busy Pets! Feed the dog some treats, watch the hamster turn in its wheel and visit the bunny in the garden. Young children will love playing with this bright and colourful board book with a gentle rhyme and wonderful illustrations by Louise Forshaw, which is part of the Busy Book series. Busy Pets has been endorsed and recommended by Dr Amanda Gummer's Good Toy Guide.Discover more in the Busy Book series: Busy Farm, Busy Party and Busy Zoo.

Discover a world of insight and mindfulness in this playful board book introduction to Tarot!Help the littlest Tarot readers discover their inner world! As one baby journeys through the day, facing down the many challenges of being a tot, readers will get to know the Tarot deck and the insight and strength that can be drawn from each card. Tarot can be used as a form of meditation--filled with mindful moments and self-reflection, each of the 22 cards in the Major Arcane provide a chance to ground your little one in the moment.

Explore the big outdoors in these action-packed animal board books with sliders on every page. Published in collaboration with the National Trust, this brand new series of board books will inspire a love of nature in even the littlest of animal lovers. With vibrant artwork printed on white board, robust easy-to-use mechanisms for tiny hands and a rhyming text with friendly animal facts, these are the perfect books to captivate curious little explorers time and time again.In this first seaside book, there are crabs to find in rock pools, dolphins playing in the sea, turtles paddling underwater and many more sea creatures to bring to life with the moving parts. Other titles in the series include: Countryside

The original, award-winning Felt Flap series – perfect for babies and toddlers!Each title in this stylish series has five spreads with friendly characters to find behind colourful felt flaps.In Where’s Mr Puffin?, you’re on the look out for Mrs Kingfisher, Mr Blackbird, Mrs Swan and Mr Puffin himself!Lift the final flap and there’s a surprise mirror – always a hit with the little ones.Parents adore these books because they are beautiful but tough enough to withstand even the most enthusiastic of young readers. And children love them because they are just so much fun.Published in collaboration with the National TrustOther titles in the series include Felt Flaps Where’s Mr Lion?, Felt Flaps Where’s Mr Unicorn? and Felt Flaps Where’s Mrs Ladybird?Felt Flaps Where’s Mr Lion? won Sainsbury’s Children’s Book of the Year 2017The felt flaps in this sturdy board book are perfect for little ones to turn and tug, which means you can get even the tiniest tot into books and finding the activity fun

Push, pull and slide the moving mechanisms to bring the story to life in this brilliant board book based on the classic picture book The Smartest Giant in Town by the creators of The Gruffalo, Julia Donaldson and Axel Scheffler. Meet George, a very helpful giant with a new, smart outfit! But what happens when he bumps into some animals who desperately need his help - and his clothes? Move the clever push, pull and slide mechanisms on every spread to join in the fun and find out. With a short, simple rhyming text based on the original story, The Smartest Giant: A Push, Pull and Slide Book is the perfect introduction for preschoolers to The Smartest Giant by Julia Donaldson and Axel Scheffler.Celebrate twenty years of this much-loved classic story with this fun novelty book - a great gift for fans of the original picture book. Enjoy more books in the Julia Donaldson and Axel Scheffler push, pull and slide range with titles based on all your favourite picture books including The Gruffalo,

A sturdy board book edition of this bestselling story - perfect for the youngest readers to sink their teeth into! Timothy Pope, Timothy Pope, what can you see through your telescope?Is there really a shark in the park? Go on, be brave, open the book and see!Timothy Pope has a brand new telescope and he's testing it out in the park. Peep through the die-cut holes in this book to see if you can spy a shark. Is that really a shark? Turn the page and find out .. . A delightful, entertaining story - with its rhyming story and ingenious die-cut pages, this is a book children will want to read again and again.

Find out what it takes to be a doctor in this exciting board book with press-out models!Look after patients and discover what it takes to be a doctor. Follow the story of a doctor's day in the hospita

Join Father Christmas on his busiest night of the year in this playful, interactive flap book!Ho, ho, ho! Can you help Father Christmas to deliver all the presents? Join in and use the flaps to wrap t

The perfect gift for the youngest of readers!With five tuggable felt flaps to lift, friendly characters and a surprise mirror ending, there's so much to discover in a Felt Flaps book!Stylish, fun and incredibly durable, the Where's Mr/s? books have earned their reputation as the must-have lift-the-flap series for babies and toddlers. In the super-festive Where's Mr Polar Bear?, little ones are on the look out for Mrs Walrus, Mr Hare, Mrs Reindeer and Mr Polar Bear. Other titles in the series include, Where's Mrs Doctor?, Where's Mrs T Rex? and Where's Mr Fire Engine?Where's Mr Lion? won Sainsbury's Children's Book of the Year 2017"The felt flaps in this sturdy board board are perfect for little ones to turn and tug, which means you can get even the tiniest tot into books and finding the activity fun.Ingela Arrhenius' illustrations are a real bonus. They are bright and retro and sure to capture your baby's attention. A perfect book to share with very little ones." BookTrust

Cleverly disguised by the shape of the letters children can find which animals are hiding under each letter in this fun lift-the-flap book.An alphabet of animals is hiding under each letter in this fu