商品簡介
"... This book provides the essentials in a simple and easy to understand way, suitable for use as a primer for researchers new to this highly studied microbe, especially if coming to yeast from another organism... very well referenced, providing both classic seminal studies as well as more recent publications, making it a useful text for those starting out in the field..." – Phenotype, 2010
Yeast is one of the oldest domesticated organisms and has both industrial and domestic applications. In addition, it is very widely used as a eukaryotic model organism in biological research and has offered valuable knowledge of genetics and basic cellular processes. In fact, studies in yeast have offered insight in mechanisms underlying ageing and diseases such as Alzheimers, Parkinsons and cancer. Yeast is also widely used in the lab as a tool for many technologies such as two-hybrid analysis, high throughput protein purification and localization and gene expression profiling. The broad range of uses and applications of this organism undoubtedly shows that it is invalubale in research, technology and industry.
This book is an up-to date resource providing a comprehensive account of yeast biology and its use as a tool and model organism for understanding cellular and molecular processes of eukaryotes. Topics covered range from the fundamentals of yeast biology such as cell structure, biochemistry, genetics and signaling, to current approaches and applications such as metabolomics, disease models and uses in biotechnology. Written by a top expert in the field, this book offers an invaluable companion to beginners and experts in yeast research.
作者簡介
Horst Feldmann studied Organic Chemistry in Cologne and did his PhD in this discipline. From 1962 to 1967 he worked at the Institute of Genetics in Cologne. In 1974 he became Professor of Physiological Chemistry at the Medical Faculty in Munich. His pioneering research included sequencing yeast tRNA. He extensively studied tRNA and protein biogenesis, yeast retrotransposons and mitochondrial genome and was a co-ordinator in the EU project "Sequencing and Analysis of the Yeast Genome". From 1971 until 2007 he was one of the organizers of the International "Spetses Summer Schools on Molecular and Cell Biology". Horst Feldmann was a member of the Board of FEBS and served as chairman of the Advanced Courses Committee, Secretary of the Prize "Biochemical Analysis" and the Head of SFB "Mechanisms and Factors in Gene Regulation". He has also served as member of a number of different committees, namely the DFG, IUBMB, DISNAT (German-Israeli cooperation). He is also an Honorary Member of Hellenic Society for Biochemistry and Biophysics. In 1996 he received the FEBS Diplome d'Honneur.
目次
Introduction
The "Early Days" of Nucleic Acids
Genetic Engineering and Reverse Genetics
Cell Structures and Functions
Cellular Dynamics
Anatomy of the Transcription Machinery and Auxiliary Complexes
Chromatin Remodeling
Molecular Signalling Cascades and Gene Regulation
Yeast Organellar Function and Biogenesis
The Yeast Genome and Post-Genomics
Disease Genes in Yeast
Yeast Biotechnology
Epilogue: The Future of Yeast Research
