Biomechatronic Design In Biotechnology: A Methodology For Development Of Biotechnological Products

From the perspective of mechanical design engineering, but for readers with backgrounds in biotechnology and mechanics and electronics, Mandenius and Bjorkman (engineering biology and assembly technology, Linkoping U., Sweden) introduce the design principles and methodology of biomechatronics. They explain its fundamentals and theory, and how it integrates biological technology with mechanical and electric engineering. They detail research methods such as schemes and matrices for analyzing the functionality of the products, ranking methods for screening and scoring the best design solutions, and structuring graphical tools for an investigation of the subsystems and sub-functions of products, and give examples of applications for blood glucose sensors, surface plasmon resonance biosensor devices, a diagnostic device for Heliobacter pylori infection, microarray devices, microbial and cellular bioreactors, chromatographic protein purification, stem cell manufacturing, bioartificial organ-stimulating devices, and process analytical technology and quality by design. Annotation c2011 Book News, Inc., Portland, OR (booknews.com)

Professor Carl-Fredrik Mandenius is head of the Division of Biotechnology at Linkoping University in Sweden. His main research interests include biochemical and bio-production engineering, bioprocess monitoring and control, stem cell technology, and biosensor technology. He was a director for process R&D at Pharmacia AB and has coordinated several EU networks on hESC-derived models for drug testing.

Professor Mats Bjorkman is head of the Division of Assembly Technology at Linkoping University in Sweden. His main research interests include design and operation of flexible manufacturing systems and equipment. He has also been involved in research that has developed from traditional mechanical industries to include areas such as electronic manufacturing and manufacturing of biotech equipment, as well as pharmaceutical products.

Preface.

1.Introduction.

I. Fundamentals

2. Conceptual Design Theory.

3. Biotechnology and Mechatronic Design.

4. Methodology for Utilization of Mechatronic Design Tools.

II. Applications.

5. Blood Glucose Sensors.

6. Surface Plasmon Resonance Biosensor Devices.

7. A Diagnostic Device for Helicobacter pylori Infection.

8. Microarray Devices.

9. Microbial and Cellular Bioreactors.

10. Chromatographic Protein Purification.

11. Stem Cell Manufacturing.

12. Bio-artificial Organ-simulating Devices.

13. Applications to Process Analytical Technology and Quality-by-Design.

14. Glossary.

15. Index.