Catalytic Methods In Asymmetric Synthesis: Advanced Materials, Techniques, And Applications

This book covers advances in the methods of catalytic asymmetric synthesis and their applications. Coverage moves from new materials and technologies to homogeneous metal-free catalysts and homogeneous metal catalysts. The applications of several methodologies for the synthesis of biologically active molecules are discussed. Part I addresses recent advances in new materials and technologies such as supported catalysts, supports, self-supported catalysts, chiral ionic liquids, supercritical fluids, flow reactors and microwaves related to asymmetric catalysis. Part II covers advances and milestones in organocatalytic, enzymatic and metal-based mediated asymmetric synthesis, including applications for the synthesis of biologically active molecules. Written by leading international experts, this book consists of 16 chapters with 2000 References and illustrations of 560 schemes and figures.

MICHELANGELO GRUTTADAURIA is Full Professor of Organic Chemistry at the University of Palermo. His fields of interest have previously included heterocycle synthesis, physical organic chemistry, and stereoselective synthesis using organoselenium chemistry. His current interests include organocatalysis and new supported recyclable catalysts. Dr. Gruttadauria is the author of over eighty papers and reviews.

FRANCESCO GIACALONE, PhD, is a Researcher in the Organic Chemistry Department at the University of Palermo. He is author or coauthor of about forty scientific papers, including four reviews in peer-reviewed journals, as well as fifteen book chapters and forty congress presentations. His current research interests focus on the preparation of recyclable materials in heterogeneous catalysis for organic synthesis. In addition, Dr. Giacalone coedited the book Fullerene-Polymers: Synthesis, Properties and Applications, published by Wiley.

Part I. New materials and technologies: supported catalysts, supports, self-supported catalysts, chiral ionic liquid, supercritical fluids, flow reactors and microwaves.

1.Recyclable stereoselective catalysts (Carlos M. Monteiro, Alexandre F. Trindale, Pedro M. P. Gois and Carlos A. M. Afonso).

2. Recyclable organocatalysts in asymmetric reactions (Michelangelo Gruttadauria, Francesco Giacalone and Renato Noto).

3. Synthesis and characterization of supported chiral catalysts (Carmela Aprile, Hermenegildo Garcia and Paolo Pescarmona).

4. Synthesis of chiral catalysts supported on organic polymers (Tor Erik Kristensen and Tore Hansen).

5. Self-supported chiral catalysts (Hongchao Guo and Kuiling Ding).

6. Catalysis with chirally modified metal surfaces: scope and mechanisms (Angelo Vargas, Cecilia Mondelli and Alfons Baiker).

7. Chiral ionic liquids for asymmetric reactions (Annie-Claude Gaumont, Yves Génisson, Frédéric Guillen, JC Plaquevent and Vacheslav Zgonnik).

8. Asymmetric reactions in flow reactors (Munawwer Rasheed, Simon C. Elmore and Thomas Wirth).

9. Asymmetric catalytic synthesis in supercritical fluids (Tomoko Matsuda).

10. Microwave-assisted transition metal-catalyzed asymmetric synthesis (Luke R. Odell and Mats Larhed).

Part II. Recent advances in organocatalytic, enzymatic and metal-based mediated asymmetric synthesis.

11. Recent advances on stereoselective organocatalytic reactions. Organocatalytic synthesis of natural products and drugs (Monika Ray and Vinod K. Singh).

12. Recent advances in biocatalysis applied to organic synthesis (Gonzalo de Gonzalo, Iván Lavandera and Vicente Gotor).

13. Peptides for asymmetric catalysis (Matthias Freund and Svetlana Tsogoeva).

14. Siliciate-mediated steroselective reactions catalyzed by chiral Lewis bases (Maurizio Benaglia, Stefania Guizzetti and Sergio Rossi).

15. Recent advances in the metal-ctalyzed steroselective synthesis of biologically active molecules (Catalina Ferrer, Xavier Verdaguer and Antoni Riera).

16. Stereoselective nitrogen heterocycles synthesis mediated by chiral metal catalysts (Sherry R. Chemler).