Metabolomics By In Vivo Nmr

Metabolism By In Vivo NMR reviews and extends the experimental and theoretical reports concerning in vivo NMR, a pioneering approach that offers versatile new ways of studying metabolic pathways. Perfectly timed to coincide with recent findings that demonstrate the novelty and strength of this approach, the book covers recent applications in biochemistry, medicine, and psychology; in vivo NMR techniques; MCA; glucose metabolism focusing on glycogen; the value of muscle glycogen measurements in exercise; and much more.

• This book is unique in linking in vivo ¹³C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states
• Provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders
• Novel and potentially controversial
• Will inspire future research directions.

Editors: Robert G. Shulman and Douglas L. Rothman, Yale University School of Medicine, New Haven, Connecticut, USA

Contributors.

Foreword (Sir George K. Radda, Medical Research Council, UK).

Section A: Background.

1 Introduction (Robert G. Shulman).

2 In Vivo NMR Spectroscopy – Techniques; Direct Detection; MRS; Kinetics and Labels; Fluxes; Concentrations (Robin de Graaf).

3 Metabolic Control Analysis for the NMR Spectroscopist (David A. Fell).

Section B: ¹³C and ³¹P NMR Studies of the Regulation of Glucose Metabolism.

4 MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 Diabetes (Gerald I. Shulman and Douglas L. Rothman).

5 Phosphorylation of Allosteric Enzymes can serve Homeostasis rather than Control Flux: the Example of Glycogen Synthase (James R.A. Schafer, David A. Fell, Douglas Rothman and Robert G. Shulman).

6 Regulation of Glycogen Metabolism in Muscle during Exercise (Thomas B. Price).

7 ¹³C NMR Studies of Heart Glycogen Metabolism (Maren R. Laughlin, Douglas L. Rothman and Robert G. Shulman).

8 Bioenergetics Implication of Metabolic Fluctuation during Muscle Contraction (Thomas Jue).

9 Lactate, Glycogen and Fatigue (Robert G. Shulman and Douglas L. Rothman).

10 Futile Cycling in Yeast: How to Control Gluttony in the Midst of Plenty (Jan den Hollander and Robert G. Shulman).

11 Trehalose Energetics in Yeast Spores (Robert G. Shulman and Jan den Hollander).

12 Metabolic Networks in the Liver by ²H and ¹³C NMR (A. Dean Sherry and Craig R. Malloy).

13 Summarized Reflections on Metabolism (Robert G. Shulman and James R. A. Schafer).

Index.