The Dose Makes The Poison: A Plain-Language Guide To Toxicology, Third Edition

This new edition of a widely-read and highly-acclaimed book broadens the scope of its predecessors from a heavy focus on industrial chemicals as toxicants to include drugs, food additives, cosmetics and other types of compounds that people are exposed to daily. Also new to the 3^rd edition are newer issues-of-the-day such as nanoparticulate toxicants, second hand smoke, food contamination, lead in toys, and others. As such, the book provides the basics of toxicology in easy-to-understand language as well as a fuller understanding of the daily insults to which our bodies are subjected.

Patricia Frank is President of Patricia Frank & Associates, Inc., a consulting firm founded in 1993 that assists companies in the development and registration of human and veterinary pharmaceutical agents. She is a past president of both the American College of Toxicology and the Roundtable of Toxicology Consultants.

M. Alice Ottoboni lectures, writes, and consults in the field of toxicology. As Staff Toxicologist with the California State Department of Public Health for over twenty years, she originated, designed, and performed numerous toxicological studies of environmental factors of importance to public health. She is the author of the previous editions of The Dose Makes the Poison.

Introduction to the Third Edition.

Preface to the Second Edition.

1 WHAT ARE CHEMICALS?

Atoms and Molecules.

Natural Chemicals.

Synthetic Chemicals.

Chemical Categories.

Chemicals: "Good" and "Bad".

Why the "Good-Bad" Dichotomy?

Man-made Chemicals Are Made by Humans.

Man-made Chemicals May Not Be Biodegradable.

Man-made Chemicals May Be Very Complex.

2 WHAT HARM DO CHEMICALS CAUSE?

Harmful Properties of Chemicals.

Explosiveness and Reactivity.

Flammability and Combustibility.

Radioactivity.

Corrosiveness.

Irritation.

Sensitization and Photosensitization.

Toxicity.

Multiple Harmful Properties.

Definition of Poison.

Definition of Hazard.

3 WHAT IS TOXICOLOGY?

Empirical Toxicology.

Paracelsus and Ramazzini.

A Brief History of Toxicology.

Toxicology Today.

What Do Toxicologists Do?

4 WHAT FACTORS INFLUENCE THE TOXIC EFFECTS OF CHEMICALS?

Acute versus Chronic Toxicity.

Significance of Divided Doses.

Routes of Exposure.

Dermal Exposure.

Inhalation Exposure.

Oral Exposure.

Other Routes of Exposure.

Combinations.

Influence of Route on Toxicity.

Metabolism.

Routes of Elimination (Excretion).

Other Factors that Influence Toxicity.

Species.

Sex.

Age.

Nutrition.

State of Health.

Biochemical Individuality (Genetic Diversity).

Presence of Other Chemicals.

Adaptation.

Light.

5 HOW IS TOXICOLOGY STUDIED?

Experimental Methods.

Acute Toxicity.

Irritant and Corrosive Effects.

Sensitization and Photosensitization.

Chronic Toxicity.

Mutagenesis.

Carcinogenesis.

Developmental and Reproductive Toxicity.

Units of Trace Quantities.

Analytical Methods.

Animal Rights.

6 GENERAL TOXICOLOGY.

Acute Toxicity.

LD₅₀ and LC₅₀ Values.

Significance of LDs for Humans.

Poison Prevention.

Antidotes.

Chronic Toxicity.

No-Effect Levels and Thresholds.

Margins of Safety.

Sufficient Challenge.

Bioaccumulation.

7 MUTAGENESIS AND CARCINOGENESIS.

Mutagenesis.

Genetic Code.

Mutations.

Significance of Mutations.

Mutation and Cancer.

Carcinogenesis.

What Is Cancer?

Causes of Cancer.

Role of Mutation.

Incidence of Cancer.

Categories and Characteristics of Carcinogens.

Induction Periods.

Thresholds.

Practical Thresholds.

The Real World.

Benzo[a]pyrene.

Cancerophobia.

8 DEVELOPMENTAL AND REPRODUCTIVE TOXICITY.

Male and Female Reproductive Systems.

Prepuberty Systems.

Adult Systems.

The Developing Individual.

9 CASE STUDIES IN TOXICOLOGY.

Environmental Contaminations.

Dioxins: Seveso, Italy.

PCBs and Dibenzofurans: Yusho Disease.

Bophal, India.

Minamata Disease.

DDT.

Consumer Products.

Metals.

Lead and Cadmium.

Zinc.

Plastics.

Bisphenyl A.

Indoor Air Pollution.

Water Pollution.

Pharmaceuticals.

Fen-Phen.

Vioxx.

Thalidomide.

10 EPIDEMIOLOGY.

Origins of Modern Epidemiology.

Epidemiology of Noninfectious Diseases.

Koch’s Postulates.

Study Design: Precepts and Pitfalls.

Unreasonable Expectations.

Proximate Event Approach in Assigning Cause.

Distrust of Science and Scientists.

11 THE STUDY OF RISK.

Public Health Statistics.

Inherent Risk.

Risk Assessment.

Perceived Risk.

Acceptable Risk.

Risk Benefit and Cost Benefit.

Risk Communication.

Risk Management.

Bibliography.

Abbreviations.

Glossary.

Appendix A.

Index.