A Practical Guide To Supramolecular Chemistry

A Practical Guide to Supramolecular Chemistry is an introductory manual of practical experiments for chemists with little or no prior experience of supramolecular chemistry. Syntheses are clearly presented to facilitate the preparation of acyclic and macrocyclic compounds frequently encountered in supramolecular chemistry using straightforward experimental procedures.

Many of the compounds can be used to illustrate classic supramolecular phenomena, for which clear directions are given, or may be developed further as part of the reader's own research. The book also describes techniques commonly used in the analysis of supramolecular behaviour, including computational methods, with many detailed examples.

An invaluable reference for students and researchers in the field embarking on supramolecular chemistry projects and looking for a 'tried and tested' route into the chemistry of key compounds.

An introductory guide to practical syntheses focusing on supramolecular chemistry.

Fully referenced introductions explain the historical and contemporary importance of each compound

Supplementary website including 3D molecular structures, FAQ's about syntheses and suggestions for further experiments

Dr Peter J. Cragg, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK

Preface.

Introduction.

1. Linear xomponents for supramolecular networks.

1.1 Flexible components.

1.2 Rigid components from schiff bases.

1.3 Flexible tripods.

1.4 Simple anion hosts.

1.5 Rigid platforms.

2. Cyclic synthons.

2.1 Planar macrocycles from nature.

2.2 Artificial planar macrocycles - phthalocyanines andother cyclic systems.

2.3 Serendipitous macrosycles.

2.4 Adding functionality to the crowns.

2.5 Azacrowns with sidearms.

2.6 Water-soluble macrosycles.

2.7 Catenanes and rotaxanes.

3. Molecular baskets, chalices and cages.

3.1 One for beginners.

3.2 Calixarences - essential supramolecular sythons.

3.3 Adding lower rim functionality to the calixarenes.

3.4 Adding upper rim functionality to the calixarenes.

3.5 Oxacalix[3]arenes.

3.6 Oxacalixarene derivatibves.

3.7 Azacalix[3]arenes.

3.8 Calixarene variations.

3.9 Molecular cages for cations and anions.

4. Supramolecular assembly.

4.1 Detection, measurement, prediction and visualization.

4.2 X-ray crystallography.

4.3 Spectroscopic and spectrmetric techniques.

4.4 Binding constant determination.

4.5 Solid state vs. solution behavour.

4.6 Supramolecular chemistry in silico: molecular and associated techniques.

4.7 Computational approaches.

4.8 A protocol for supramolecular computational chemistry.

4.9 Examples of in silico supramolecular chemistry.

5. Supramolecular phenomena.

5.1 Clathrates.

5.2 Stabilization of cation-anion pairs by by crown ethers: liquid clathrates.

5.3 Receptors for the ammonium ion.

5.4 Purification of fullerenes.

5.5 Making molecular boxes and capsules.

5.6 Self-complimentary species and self-replication.

Appendix 1: Integrated undergraduate projects.

Appendix 2: Reagents and solvents.

Index.