CELLULAR ASPECTS OF HIV INFECTION

Cellular Aspects of HIV Infection provides a highly readable, detailed overview of the state of the art in modern HIV research at the cellular level. This volume brings together renowned experts who have provided concise, synthetic treatments of the biology of HIV infection. It presents these descriptions and analyses with particular attention to the techniques of flow cytometry that have allowed us to not only observe the course of HIV infection and the immune system's response to it, but have also increased our ability to treat patients and understand their response to therapy.

The book is divided into five sections covering molecules and cells, pathophysiological processes, technologies, and organisms. A perspective on future therapies concludes the book. Each chapter offers an intelligent, concise synthesis of the topic, highlighting the biological principles and technologies involved in the study of HIV infection. Cellular Aspects of HIV Infection is an indispensable, up-to-date guide for immunologists, virologists, clinicians, and researchers.

Andrea Cossarizza is currently Professor of Immunology at the Modena and Reggio Emilia university School of Medicine. He received his MD from the University of Padua, and PhD from the Universities of Modena and Bologna. His professional experience includes: 1986-1988 Fellow, Chair of Immunology, Modena University; 1991-pres Responsible, Flow Cytometry Unit, Chair Immunol.; 1996-pres Responsible, Research Unit on HIV, Department Infect. Dis., Modena; Chairman session "Cell Proliferation", I World Congress for Electricity and Magnetism in Biology and Medicine, Orlando, 1992; Chairman session "Neuroimmunoendocrinology", 39th National Congress of the Italian Society of Geriatrics, Florence, 1994; Member of: Int. Soc. for Analytical Cytology, Ital. Immunol. Society; Referee of Int. Human Frontier Science Program Organization (HFSPO) 1994-1998; Referee for AIDS, FEBS Lett., Exp. Cell Res., Immunology Lett., Aging - Clin. Exp. Res, J. Endocrinol. Invest.
Guest Editor of an issue of International Reviews of Immunology.
He has published aproximately 140 papers in peer-reviewed journals and edited 3 books.

Preface.

Contributors.

Part I: MOLECULES.

1. HIV and Molecular Biology of the Virus-Host Interplay (Massimo Clementi).

2. Telomere Length, CD28? T Cells, and HIV Disease Pathogenesis (Rita B. Effros).

3. Immune Dysregulation and T-Cell Activation Antigens in HIV Infection (Mara Biasin, Fulvia Colombo, Stefania Piconi, and Mario Clerici).

4. Quantification of HIV/SIV Coreceptor Expression (Benhur Lee and Robert W. Doms).

Part II: CELLS.

5. B Cells in the Line of Sight of HIV-1 (Yolande Richard, Eric A. Lef?vre, Roman Krzysiek, Christophe Legendre, Dominique Dormont, Pierre Galanaud, and Gabriel Gras).

6. Cytotoxic T-Cell (CTL) Function in HIV Infection (M. L. Garba and J. A. Frelinger).

7. Analysis of the /
T-Cell Receptor Repertoire in HIV Infection (Hugo Soudenys).

8. Gamma-Delta () T Cells and HIV-1 Infection (Roxana E. Rojas and W. Henry Boom) 9. Natural Killer Cells in HIV Infection and Role in the Pathogenesis of AIDS (Benjamin Bonavida).

10. Alveolar Macrophages (Jianmin Zhang and Henry Koziel).

11. Dendritic Cells Ferry HIV-1 from Periphery into Lymphoid Tissues (Teunis B. H. Geijtenbeek and Yvette van Kooyk).

Part III: PROCESSES.

12. Homeostasis and Restoration of the Immune System in HAART Treated HIV-Infected Patients: Implications of Apoptosis (Marie-Lise Gougeon, Herv? LeCoeur, Luzia Maria de Oliveira Pinto, and Eric Ledru).

13. Mitochondria Functionality During HIV Infection (Andrea Cossarizza, Marcello Pinti, Milena Nasi, Maria Garcia Fernandez, Laura Moretti, Cristina Mussini, and Leonarda Troiano).

14. Multiple Roles of Cytokines in HIV Infection, Replication, and Therapy (Massimo Alfano and Guido Poli). Part IV: TECHNOLOGIES.

15. The Use of Peptide/MHC Tetramers to Visualize, Track, and Characterize Class I-Restricted Anti-HIV T-Cell Response (Clive M. Gray and Thomas C. Merigan).

16. Tagging of HIV with Green Fluorescent Protein (Nadya I. Tarasova).

17. Flow Cytometric Analysis of Cells from Persons with HIV-1 Disease by Enzymatic Amplification Staining (David Kaplan).

18. Antigen-Specific Cytokine Responses in HIV Disease (Vernon C. Maino, Holden T. Maecker, and Louis J. Picker).

Part V: ORGANISMS.

19. Chimeric Models of SCID Mice Transplanted with Human Cells: The Hu-PBL-SCID Mouse and Its Use in AIDS Research (S. M. Santini, C. Lapenta, M. Logozzi, S. Parlato, M. Spada, T. Di Pucchio, S. Fais, and F. Belardelli).

20. Immune Reconstitution of the CD4 T-Cell Compartment in HIV Infection (Guislaine Carcelain, Taisheng Li, Marc Renaud, Patrice Debr?, and Brigitte Autran).

21. New Perspectives in Antiretroviral Therapy of HIV Infection (Stefano Vella).

Index.