In this timely volume, Drs. Dzau and Liew – both pioneers in the area – help cardiologists understand:
• how cardiovascular genetics may remodel the way cardiovascular medicine is practiced
• what material has immediate relevance to the practicing clinician
• how to incorporate genetics and genomics in your practice to ensure up-to-date patient care
The book opens with introductory chapters, then discusses:
• cardiovascular single gene disorders
• cardiovascular polygenic disorders
• therapies and applications
Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive. If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.
Victor J. Dzau, MD
James B. Duke Professor of Medicine, Director, Mandel Center for Hypertension and Atherosclerosis Research; and Chancellor for Health Affairs, Duke University, Durham, USA
Choong-Chin Liew, PhD
Professor Emeritus, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; and (formerly) Visiting Professor of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Foreword.
Introduction.
1 The gene in the twenty-first century.
Choong-Chin Liew, Victor J. Dzau.
Part I: Cardiovascular single gene disorders.
2 Monogenic hypercholesterolemia.
Ruth McPherson.
3 Hypertrophic cardiomyopathy.
Ali J. Marian.
4 Dilated cardiomyopathy and other cardiomyopathies.
Mitra Esfandiarei, Robert Yanagawa, Bruce M. McManus.
5 The long QT syndrome.
Sabina Kupershmidt, Kamilla Kelemen, Tadashi Nakajima.
Part II: Cardiovascular polygenic disorders.
6 Atherosclerosis.
Päivi Pajukanta, Kiat Tsong Tan, Choong-Chin Liew.
7 Heart failure.
Markus Meyer, Peter VanBuren.
8 The implications of genes on the pathogenesis, diagnosis and therapeutics of hypertension.
Kiat Tsong Tan, Choong-Chin Liew.
Part III: Therapies and applications.
9 Gene therapy for cardiovascular disease: inserting new genes, regulating the expression of native genes, and correcting genetic defects.
Ion S. Jovin, Frank J. Giordano.
10 Stem cell therapy for cardiovascular disease.
Emerson C. Perin, Guilherme V. Silva.
11 Pharmacogenetics and personalized medicine.
Julie A. Johnson, Issam Zineh.
12 The potential of blood-based gene profiling for disease assessment.
Steve Mohr, Choong-Chin Liew.
Index.
Colour plates
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