Hypoxia And Consequences - From Molecule To Malady

International experts from academia, industry and government discuss the cellular mechanisms that underlie rapid and delayed responses to oxygen deprivation, known as hypoxia. This volume brings together researchers and clinicians from developmental and cellular biology, drug development, oncology, neurobiology and medicine to discuss 1) How hypoxia-inducible factors regulate development and physiology, 2) How cells sense changes in oxygen availability, and 3) How oxygen availability affects several pathologies like pulmonary hypertension, sleep apnea, cancer and neurodegeneration.

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Introduction to Hypoxia and Consequences: From Molecule to Malady (Chris Peers, Navdeep S. Chandel, Gabriel G. Haddad).

Part I. Transcriptional Responses to Hypoxia.

1. Regulation of Vascularization by Hypoxia-Inducible Factor 1 (Gregg L. Semenza).

2. FIH-Dependent Asparaginyl Hydroxylation of Ankyrin Repeat Domain-Containing Proteins (Matthew E. Cockman, James D. Webb, Peter J. Ratcliffe).

3. From Polyps to People: A HIghly Familiar Response to Hypoxia (R.J. Hampton-Smith, D.J. Peet).

4. Maintaining Mammalian Iron and Oxygen Homeostasis: Sensors, Regulation, and Cross-Talk (Ameen A. Salahudeen, Richard K. Bruick).

5. Survival in Acute and Severe Low O₂ Environment: Use of a Genetic Model System (Priti Azad, Gabriel G. Haddad).

6. Mitochondria and Hypoxic Signaling: A New View (Robert O. Poyton, Pablo R. Castello, Kerri A. Ball, Dong Kyun Woo, Ning Pan).

7. Pathophysiological Consequences of HIF Activation: HIF as a Modulator of Fibrosis (Volker H. Haase).

8. Mitochondrial Metabolism and Cancer (Frank Weinberg, Navdeep S. Chandel).

Part II. Oxygen Sensing.

9. Molecular Imaging: Into In Vivo Interaction of HIF-1 and HIF-2 with ARNT (Rebecca Konietzny, Anna König, Christoph Wotzlaw, André Bernadini, Utta Berchner-Pfannschmidt, Joachim Fandrey).

10. Oxygen-Sensitive Potassium Channels in Chemoreceptor Cell Physiology: Making a Virtue of Necessity (Constancio Gonzalez, Luis M. Vaquero, José Ramón López-López, M. Teresa Pérez-García).

11. Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery (A. Mark Evans, D. Grahame Hardie, Chris Peers, Christopher N. Wyatt, Benoit Viollet, Prem Kumar, Mark L. Dallas, Fiona Ross, Naoko Ikematsu, Heidi L. Jordan, Barbara L. Barr, J. Nicole Rafferty, Oluseye Ogunbayo).

12. Hypoxia Selectively Inhibits KCNA5 Channels in Pulmonary Artery Smooth Muscle Cells (Amy L. Firth, Oleksandr Platoshyn, Elena E. Brevnova, Elyssa D. Burg, Frank Powell, Gabriel H. Haddad, Jason X.-J. Yuan).

13. Enzyme-Linked Oxygen Sensing by Potassium Channels (Paul J. Kemp, Vsevolod Telezhkin, William J. Wilkinson, Ruth Mears, Stuart B. Hanmer, Hanne C. Gadeberg, Carsten T. Müller, Daniela Riccardi, Stephen P. Brazier).

14. Oxygen Sensing in the Carotid Body (José López-Barneo, Patricia Ortega-Sáenz, Ricardo Pardal, Alberto Pascual, José I. Piruat, Rocío Durán, Raquel Gómez-Díaz).

15. Regulation of Oxygen Sensitivity in Adrenal Chromaffin Cells (Colin A. Nurse, Josef Buttigieg, Stephen Brown, Alison C. Holloway).

16. Oxidative DNA Modifications in Hypoxic Signaling (Mark N. Gillespie, Viktor Pastukh, Mykhaylo V. Ruchko).

17. The Neuronal Control of Hypoxic Ventilation: Erythropoietin and Sexual Dimorphism (Max Gassmann, Martha Tissot van Patot, Jorge Soliz).

Part III. Pathophysiological Responses to Hypoxia.

18. Intermittent Hypoxia-Mediated Plasticity of Acute O2 Sensing Requires Altered Red-Ox Regulation by HIF-1 and HIF-2 (Nanduri R. Prabhakar, Ganesh K. Kumar, Jayasri Nanduri).

19. Hypoxia and Neurodegeneration (Chris Peers, Mark L. Dallas, Hannah E. Boycott, Jason L. Scragg, Hugh A. Pearson, John P. Boyle).

20. The Role of NF-B in Hypoxia-Induced Gene Expression (Cormac T. Taylor, Eoin P. Cummins).

21. Role of Hypoxia-Inducible Factors in Epigenetic Regulation via Histone Demethylases (Jun Yang, Ioanna Ledaki, Helen Turley, Kevin C. Gatter, Juan-Carlos Martinez Montero, Ji-Liang Li, Adrian L. Harris).

22. An Essential Role of the HIF-1–c-Myc Axis in Malignant Progression (Young-Gun Yoo, Masami Hayashi, Jared Christensen, L. Eric Huang).