Biomedical Chemistry: Applying Chemical Principlesto The Understanding And Treatment Of Disease

How basic chemical ideas help advance the understanding and treatment of disease Biomedical Chemistry presents clear, concise coverage of the application of chemistry to drug discovery and determination of disease etiology, highlighting its role in the explosive growth of biotechnology and molecular biology. Through expert contributions from leading researchers in diverse fields, the book provides readers with an understanding of how fundamental chemical concepts are used in the development of novel approaches to the major problems in medicine today. The authors explain both the science and reasoning underlying each experimental approach, exploring cutting-edge developments in AIDS, cancer, alcoholism, Parkinson's disease, trypanosomiasis, emphysema, and malaria. Contemporary research problems discussed include:
* Mechanism-based drug discovery
* Design of new antitumor and antiviral agents
* Targeting tumors using magnetic drug delivery
* Antisense and antigene agents
Easily accessible to anyone with a solid undergraduate background in chemistry, Biomedical Chemistry is an excellent resource for researchers in health-related fields as well as anyone seeking an overview of frontier topics in medicinal chemistry, organic chemistry, and biochemistry.

PAUL F. TORRENCE, PhD, is Professor and Chair of Chemistry at Northern Arizona University in Flagstaff, and formerly Chief of the Biomedical Chemistry Section, Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, and Director of the Foundation for Advanced Education in the Sciences Graduate School at the National Institutes of Health. Dr. Torrence is widely recognized for his contributions to medicinal chemistry and has published more than 190 scientific papers and patents.

DRUG DISCOVERY AND DEVELOPMENT LEADS FROM FUNDAMENTALS OF ENZYME TRANSFORMATIONS AND MECHANISMS.

Sleeping Sickness: Irreversible Inhibitors of S-Adenosylmethionine Decarboxylase as Antitrypanosomal Agents (P. Woster).

Mechanism-Based S-Adenosyl-L-Homocysteine Hydrolase Inhibitors in the Search For Broad-Spectrum Antiviral Agents (D. Yin, et al.).

Alcoholism: Aldehyde Dehydrogenase Inhibitors as Alcohol Deterrent Agents (H. Nagasawa, et al.).

AIDS: Adenosine Deaminase-Activated Prodrugs for the Treatment of Huamn Immunodeficiency Virus in the Central Nervous System (J. Driscoll).

Anti-HIV Phosphotriester Pronucleotides: Basis for the Rational Design of Biolabile Phosphate Protecting Groups (C. Perigaud, et al.).

EXPLORATION OF FUNDAMENTAL CHEMICAL PRINCIPLES IN DRUG DESIGN AND DISCOVERY.

AIDS: Potential Inhibitors of Human Immunodeficiency Virus Replication (G. Kenyon).

From Chemical Warfare Agent to Anticancer Drug: The Chemistry of Phosphoramide Mustard (S. Ludeman).

Phosphoryltyrosyl Mimetics as Signaling Modulators and Potential Antitumor Agents (T. Burke, et al.).

Targeting Tumors Using Magnetic Drug Delivery (S. Pulfer & J. Gallo).

Cancer: Superacid Generation of New Antitumor Agents (J.-C. Jacquesy & J. Fahy).

Fluorine Substitution as a Modulator of Biological Processes (K. Kirk).

UNDERSTANDING THE CHEMICAL BASIS OF DRUG ACTION AND DISEASE.

Thiouracil and Related Thioureylene Compounds as Melanoma-Seekers: Paradigms for a Chemical Approach to the Design of Targeting Anticancer Agents (M. d'Ischia & G. Prota).

Carbon-Centered Radicals and Rational Design of New Antimalarial Peroxide Drugs (G. Posner, et al.).

The Chemistry of Parkinson's Disease (G. Dryhurst, et al.).

NOVEL CHEMISTRIES IN THE VANGUARD OF BIOTECHNOLOGY AND DRUG DISCOVERY.

New Generation of DNA Chips Based on Real-Time Biomimetic Recognition (F. Garnier).

Peptide Nucleic Acids (PNA): Towards Gene Therapeutic Drugs (P. Nielsen).

Ribozyme Mimics: The Evolution of Gene-Specific Chemotherapy (T. Osiek, et al.).

Index.