Handbook of Physics in Medicine and Biology

In considering ways that physics has helped advance biology and medicine, what typically comes to mind are the various tools used by researchers and clinicians. We think of the optics put to work in microscopes, endoscopes, and lasers; the advanced diagnostics permitted through magnetic, x-ray, and ultrasound imaging; and even the nanotools, that allow us to tinker with molecules. We build these instruments in accordance with the closest thing to absolute truths we know, the laws of physics, but seldom do we apply those same constants of physics to the study of our own carbon-based beings, such as fluidics applied to the flow of blood, or the laws of motion and energy applied to working muscle.
Instead of considering one aspect or the other,Handbook of Physics in Medicine and Biology explores the full gamut of physics’ relationship to biology and medicine in more than 40 chapters, written by experts from the lab to the clinic.
The book begins with a basic description of specific biological features and delves into the physics of explicit anatomical structures starting with the cell. Later chapters look at the body's senses, organs, and systems, continuing to explain biological functions in the language of physics.
The text then details various analytical modalities such as imaging and diagnostic methods. A final section turns to future perspectives related to tissue engineering, including the biophysics of prostheses and regenerative medicine.

The editor’s approach throughout is to address the major healthcare challenges, including tissue engineering and reproductive medicine, as well as development of artificial organs and prosthetic devices. The contents are organized by organ type and biological function, which is given a clear description in terms of electric, mechanical, thermodynamic, and hydrodynamic properties. In addition to the physical descriptions, each chapter discusses principles of related clinical diagnostic methods and technological aspects of therapeutic applications. The final section on regenerative engineering, emphasizes biochemical and physiochemical factors that are important to improving or replacing biological functions. Chapters cover materials used for a broad range of applications associated with the replacement or repair of tissues or entire tissue structures.

Dr. Robert Splinter is the Senior Scientist of Technology Development at the Spectranetics Corporation. He is also an Adjunct Assistant Professor in the Department of Physics and Optical Science at the University of North Carolina at Charlotte.

SECTION I ANATOMICAL PHYSICS1 Physics of the Cell Membrane, Thomas Wolkow2 Protein Signaling, Sonja Braun-Sand3 Cell Biology and Biophysics of the Cell Membrane, Didier Dreau4 Cellular Termodynamics, Pavlina Pike5 Action Potential Transmission and Volume Conduction, Robert Splinter
SECTION II PHYSICS OF PERCEPTION6 Medical Decision Making, Robert Splinter7 Senses, Robert Splinter8 Somatic Senses: Touch and Pain, Jean-Marc Aimonetti and Sasa Radovanovic9 Hearing, Mark S. Hedrick10 Vision, Hiroto Ishikawa, Naohiro Ikeda, Sanae Kanno, Tomohiro Ikeda, Osamu Mimura, and Mari Dezawa11 Electroreception, Robert Splinter
SECTION III BIOMECHANICS12 Biomechanics, Robert Splinter13 Artifi cial Muscle, Robert Splinter and Paul Elliott14 Cardiovascular System, Istvan Osztheimer15 Control of Cardiac Output and Arterial Blood Pressure Regulation, Istvan Osztheimer and Pal Maurovich16 Fluid Dynamics of the Cardiovascular System, Aurélien F. Stalder and Michael Markl17 Fluid Dynamics, Takuji Ishikawa18 Modeling and Simulation of the Cardiovascular System to Determine Work Using Bond Graphs, Paola Garcia19 Anatomy and Physics of Respiration, Tim Moss, Jane Pillow, and David Baldwin
SECTION IV ELECTRICAL PHYSICS20 Electrodes, Rossana E. Madrid, Ernesto F. Treo, Myriam C. Herrera, and Carmen C. Mayorga Martínez21 Recording of Bioelectrical Signals: Theory and Practice, Juha Voipio
SECTION V DIAGNOSTIC PHYSICS22 Medical Sensing and Imaging, Robert Splinter23 Electrocardiogram: Electrical Information Retrieval and Diagnostics from the Beating Heart, Orsolya Kiss24 Electroencephalography: Basic Concepts and Brain Applications, Jodie R. Gawryluk and Ryan C.N. D’Arcy25 Bioelectric Impedance Analysis, A.V. Smirnov, D.V. Nikolaev, and S.G. Rudnev26 X-Ray and Computed Tomography, Ravi Chityala27 Confocal Microscopy, Robert Splinter28 Magnetic Resonance Imaging, El-Sayed H. Ibrahim and Nael F. Osman29 Positron Emission Tomography, Robert Splinter30 In Vivo Fluorescence Imaging and Spectroscopy, Gregory M. Palmer and Karthik Vishwanath31 Optical Coherence Tomography, Kevin A Croussore and Robert Splinter32 Ultrasonic Imaging, Robert Splinter33 Near-Field Imaging, Kert Edward34 Atomic Force Microscopy, Christian Parigger35 Scanning Ion Conductance Microscopy, Shelley J Wilkins and Martin F Finlan36 Quantitative Thermographic Imaging, John Pearce37 Intracoronary Thermography, Frank Gijsen38 Schlieren Imaging: Optical Techniques to Visualize Thermal Interactions with Biological Tissues, Rudolf Verdaasdonk39 Helium Ion Microscopy, John A. Notte40 Electron Microscopy: SEM/TEM, Fernando Nieto, Juan Jimenez Millan, Gleydes Gambogi Parreira, H. Chiarini-Garcia, and R.C.N. Melo
SECTION VI PHYSICS OF ACCESSORY MEDICINE41 Lab-on-a-Chip, Shalini Prasad, Yamini Yadav, Vindhya Kunduru, Manish Bothara, and Sriram Muthukumar42 The Biophysics of DNA Microarrays, Cynthia Gibas43 Nuclear Medicine, Robert Splinter
SECTION VII PHYSICS OF BIOENGINEERING44 Biophysics of Regenerative Medicine, Amanda W. Lund, George E. Plopper, and David T. Corr