The Year In Immunology: Immunoregulatory Mechanisms

The fourth installment of "The Year in Immunology" series features reviews of novel approaches in the investigation of immunoregulatory mechanisms. Topics surveyed include cutting-edge molecular studies and treatment advances for systemic lupus erythmatosus and multiple sclerosis, the genetic regulation of lymphocytes and T cells, and new models of immunosenescence.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632.


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Preface
Noel R. Rose


Lymphoid tissue inducer cells: innate cells critical for CD4+ T cell memory responses?
Peter J.L. Lane, Fabrina M. Gaspal, Fiona M. McConnell, Mi Yeon Kim, Graham Anderson and David R. Withers


Regulation of mature T cell responses by the Wnt signaling pathway
Hai-Hui Xue and Dong-Mei Zhao


Development and function of interleukin 17-producing ?d T cells:
Thomas Korn and Franziska Petermann


Lymphocyte signaling: regulation of FoxO transcription factors by microRNAs
Claudia Haftmann, Anna-Barbara Stittrich, Evridiki Sgouroudis, Mareen Matz, Hyun-Dong Chang, Andreas Radbruch and Mir-Farzin Mashreghi


From interleukin-9 to T helper 9 cells
Michael Stassen, Edgar Schmitt and Tobias Bopp


Mechanisms of immunosenescence: lessons from models of accelerated immune aging
Sabine Le Saux, Cornelia M. Weyand and Jörg J. Goronzy


Helminth–host immunological interactions: prevention and control of immune-mediated diseases
David E. Elliott and Joel V. Weinstock


Induction of gut IgA production through T cell-dependent and T cell-independent pathways
Mats Bemark, Preben Boysen and Nils Y. Lycke


New and emerging disease modifying therapies for multiple sclerosis
Shiv Saidha, Christopher Eckstein and Peter A. Calabresi


Treatment of systemic lupus erythematosus: new advances in targeted therapy
Mindy S. Lo and George C. Tsokos