Uremic Toxins

For scientists and clinicians in nephrology, Niwa (advanced medicine for uremia, Nagoya U., Japan) assembles 23 chapters on all aspects of uremic toxins. Renal medicine, pathophysiology, nephrology, and other researchers from Europe, the US, and Japan cover the definition, classification, listing, and mass spectrometric analysis of uremic toxins; selected toxins, including indoxyl sulfate, asymmetric dimethylarginine, parathyroid hormone, and advanced glycation endproducts, and their chemical structures, metabolism, analytical methods, plasma levels, toxicity, clinical implications, and removal methods; and the therapeutic removal of toxins through hemodialysis, peritoneal dialysis, and oral sorbents. Annotation c2013 Book News, Inc., Portland, OR (booknews.com)

TOSHIMITSU NIWA, MD, PhD, is Professor in the Department of Advanced Medicine for Uremia at the Nagoya University Graduate School of Medicine. President of the Japanese Society for Biomedical Mass Spectrometry, Dr. Niwa has received many honors for his research, including the Kimoto Prize of the Japanese Society for Dialysis Therapy and the International Society of Uremia Research and Toxicity Award. He has published more than 300 articles in peer-reviewed journals.

SECTION 1: UREMIC TOXINS
Chapter 1. Uremic Toxins: An Integrated Overview of Definition and Classification Richard J. Glassock and Shaul G. Massry
Chapter 2. Classification and a List of Uremic Toxins Nathalie Neirynck, Rita De Smet, Eva Schepers, Raymond Vanholder, and Griet Glorieux
Chapter 3. Analysis of Uremic Toxins with Mass Spectrometry Toshimitsu Niwa
SECTION 2: SELECTED UREMIC TOXINS
Chapter 4. Indoxyl Sulfate Toshimitsu Niwa
Chapter 5. p-Cresyl Sulfate Anneleen Pletinck, Raymond Vanholder, and Griet Glorieux
Chapter 6. 3-Carboxy-4-methyl-5-propyl-2-furanpropionic Acid Toshimitsu Niwa
Chapter 7. Phenylacetic Acid Anna Schulz and Joachim Jankowski
Chapter 8. Homocysteine and Hydrogen Sulfide: Two Opposing Aspects in the Pathobiology of Sulfur Compounds in Chronic Renal Failure Alessandra F. Perna and Diego Ingrosso
Chapter 9. Guanidino Compounds Sunny Eloot, Griet Glorieux, Peter Paul De Deyn, and Raymond Vanholder
Chapter 10. Asymmetric Dimethylarginine Vladimír Teplan and Jaroslav Racek
Chapter 11. Nicotinamide Metabolites Przemyslaw Rutkowski and Boleslaw Rutkowski
Chapter 12. Dicarbonyls (Glyoxal, Methylglyoxal, and 3-Deoxyglucosone) Naila Rabbani and Paul J Thornalley
Chapter 13. Glucose Degradation Products in Peritoneal Dialysis Monika Pischetsrieder and Sabrina Gensberger
Chapter 14. Dinucleoside Polyphosphates Joachim Jankowski and Vera Jankowski
Chapter 15. Parathyroid Hormone Shaul G. Massry and Miroslaw Smogorzewski
Chapter 16. β2-Microglobulin Suguru Yamamoto, Junichiro James Kazama, Hiroki Maruyama, Ichiei Narita, and Fumitake Gejyo
Chapter 17. Cytokines Björn Anderstam, Bengt Lindholm, and Peter Stenvinkel
Chapter 18. Free Immunoglobulin Light Chains Gerald Cohen and Walter H. Hörl
Chapter 19. Advanced Glycation End-Products (AGEs) Naila Rabbani and Paul J Thornalley
Chapter 20. Oxidized Albumin Maurizio Bruschi, Giovanni Candiano, Laura Santucci, and Gian Marco Ghiggeri
SECTION 3: THERAPEUTIC REMOVAL OF UREMIC TOXINS
Chapter 21. Therapeutic Removal of Uremic Toxins by Hemodialysis Tammy L. Sirich, Pavel Aronov, and Timothy W. Meyer
Chapter 22. Therapeutic Removal of Uremic Toxins by Peritoneal Dialysis Malgorzata Debowska, Elvia García-López, Jacek Waniewski, and Bengt Lindholm
Chapter 23. Therapeutic Removal of Uremic Toxins by Oral Sorbent Toshimitsu Niwa
Index