Chemical Biology In Regenerative Medicine - Bridging Stem Cells And Future Therapies

Regenerative medicine is a highly interdisciplinary field, with contributions from medicine, engineering, and chemistry. Chemical biology plays a key role – small molecules are involved in differentiating, reprogramming and manipulating stem cells and in enabling transplantation.

In Chemical Biology in Regenerative Medicine, an international team of experts provides an overview of progress towards clinical application in the areas of transplantation (allogenic and autologous), manipulation of niche environment and homing, and cell reprogramming (trans-differentiation and de-differentiation). The book highlights the interdisciplinary approaches undertaken to resolve current technical problems in regenerative medicine, with special attention paid to small molecules and biomaterials engineering. It also includes an overview of the current regulatory climate and discusses the future of these therapies. Topics covered include:

• Wnt Signaling in Regulation of Stem Cells
• Directed Cardiomyogenesis of Pluripotent Stem Cells
• Chemical Genetics in Cardiomyocyte Generation
• Challenges and New Directions for Cardiac Reprogramming
• Comparative Analysis of Adult Stem Cell Niches
• Chemicals and Stem Cells for Promoting Regeneration
• Chemically Induced Pluripotent Stem Cells (CiPSC): A Potential Chemical Biological Breakthrough in Reprogramming?
• An Introduction to Cellular Reprogramming: The Plasticity of Cell Fates and Identities
• Chemicals Facilitating Reprogramming
• Chemicals Facilitating Reprogramming: Targeting the SAM Binding Site to Identify Novel Methyltransferase Inhibitors
• Biomaterials for Directed differentiation

Chemical Biology in Regenerative Medicine is an essential overview of this emerging technology for researchers in academia, industry and clinical settings working in regenerative medicine, chemical biology, biochemistry, cell biology, biomaterials and bioengineering.

Dr Charles C. Hong is a physician-scientist with background in molecular biology, developmental biology, chemical biology, and cardiovascular genetics. He is an Associate Professor of Cardiovascular Medicine, Pharmacology, and Cell and Developmental Biology, and a member of the Veterans Affairs Tennessee Valley Healthcare System.? He is also a member of the Vanderbilt Institute of Chemical Biology and the Vanderbilt Center for Stem Cell Biology.?Dr. Hong received his MD-PhD with Honors from Yale, then completed cardiology fellowship at Massachusetts General Hospital, where he was a Schreyer Fellow, and postdoctoral fellowship at Harvard Medical School, where he was a Sarnoff Scholar. After a brief stint on the Harvard Medical School faculty, Dr. Hong came to Vanderbilt in 2006.?The Hong laboratory is focused on Chemical Biology of vertebrate development and stem cell differentiation, specifically Chemical Genetics of Embryonic Development; Regenerative Chemical Biology & Drug Discovery/ Experimental Therapeutics.

Dr Ada S. Ao, Postdoctoral Research Fellow, Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, USA.

Prof Jijun Hao, Research Assistant Professor, Western University of Health Sciences, USA.