Microrna ― Medical Evidence: from Molecular Biology to Clinical Practice

The book provides the most updated and comprehensive microRNA (miRNA) clinical evidence from worldwide renowned scientists. It is now known that miRNAs can suppress the expression of key genes involved in several cellular processes, including cell differentiation, development, migration, proliferation, and apoptosis. This dedicated work focuses on the medical evidence associated with the biological miRNA machinery at the clinical level. Chapters are devoted to topics including microRNA and: personalized medicine, diabetic kidney disease, multiple sclerosis, Parkinson's Disease, heart failure, colorectal cancer, Alzheimer's disease and many more.microRNA: Medical Evidence complements the basic science covered in the companion volumemicroRNA:Basic Biology as well as the cancer-specific research in microRNA: Cancer. Taken together, these three volumes provide essential information for physicians who want to gain a better understanding of this emerging field in the clinical scenario (both as diagnostic marker and for therapeutic opportunities), as well as for scientists, biologists, geneticists, and biomedical researchers investigating the role of these molecules in their specific research projects. It is also useful for advanced graduate students and postdoctoral fellows who want to learn more about innovative and essential mechanisms of gene regulation.

Dr. Gaetano Santulli received his MD and PhD at the University of Naples “Federico II”. A physician scientist, Dr. Santulli completed his postdoctoral training at Columbia University Medical Center in New York City, supported by an AHA fellowship and a Scientist Development Grant. Cardiologist, he authored more than 100 publications, including peer-reviewed articles in high impact journals, book chapters, and medical books. He is currently a faculty member of Columbia University. He lives in Manhattan.

Dr. Santulli’s expertise comprises both clinical and basic research topics, including hypertension, diabetes, angiogenesis, heart failure, arrhythmias, vascular disorders, and skeletal muscle disease. He is a member of several international academic societies, including New York Academy of Sciences, American Heart Association (AHA), American Diabetes Association, European Society of Cardiology, Endocrine Society, American Association for the Advancement of Science, European Association of Heart Failure, European Association of Echocardiography, Acute Cardiovascular Care Association, European Association of Percutaneous Cardiovascular Interventions. He serves on the Editorial Boards of numerous medical Journals.