The Functions, Disease-Related Dysfunctions, And Therapeutic Targeting Of Neuronal Mitochondria

This book presents advances in the field of neuronal mitochondria – functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases.

‧ Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death
‧ Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments
‧ Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field
‧ Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders

Valentin Gribkoff is the former Chief Scientific Officer and Senior Vice President of Discovery Research at Knopp Neurosciences as well as a scientific consultant for pharmaceutical companies. He is currently a Visiting Research Scientist in the Department of Medicine at Yale University School of Medicine and a Founding Member of the Northwoods Group, a Biotech Consultant/Development group. He co-edited the bookStructure, Function and Modulation of Neuronal Voltage-Gated Ion Channels (Wiley 2009) and is Series Editor for the Wiley Series on Neuropharmacology.

Elizabeth Jonas is an Associate Professor at the Departments of Internal Medicine, Section of Endocrinology, and Neurobiology at Yale University School of Medicine.

J. Marie Hardwick is the David Bodian Professor of Molecular Microbiology and Immunology at The Johns Hopkins Bloomberg School of Public Health.