Computational Pharmaceutical Solid State Chemistry

Recent trends within the pharmaceutical industry through the Quality by Design initiatives have seen a greater emphasis on the development of a molecular-scale understanding in the development of efficient manufacturing processes for active pharmaceutical ingredients (APIs) and their formulation into drug products. This book examines the state-of-the-art computational approaches to guide solid form experiments to optimize the physical and chemical properties of API related to its stability, bioavailability and formulatability.

The book is intended to be used as a professional reference to researchers in Pharmaceutical industry and in academia and potentially as a text book reference for undergraduate, graduate and postgraduate students in the field of Computational Chemistry, Solid State Chemistry, Pharmaceutical Science and Material Science.

Yuriy A. Abramov, PhD, is a Senior Principal Scientist with over 14 years of experience in computational sciences in drug discovery and development with Pfizer, Inc., in Groton, CT, USA. He holds a PhD in Physical Chemistry from the D. Mendeleev University of Chemical Technology of Russia and Karpov Institute of Physical Chemistry in Moscow.