Theory And Applications Of The Empirical Valence Bond Approach - From Physical Chemistry To Chemical Biology

Over the past couple of decades, Empirical Valence Bond (EVB) approaches have become one of the key tools for studying chemical processes in condensed phases and proteins. This book provides a comprehensive overview of these advances, highlighting how they have shaped our current understanding of enzyme catalysis and chemical processes in general. Written by leading scientists in the field, the book focuses on the applications and extension of the original EVB approach to a variety of different areas of research, including reaction dynamics, design of artificial catalysts, and the study of complex biological problems.

The book begins with concise yet comprehensive introduction to the basic concepts and historical background of valence bond theory, and EVB specifically. Subsequent chapters discuss the application of EVB models to a broad range of molecular systems of chemical and biological interest, and highlight the effectiveness of EVB to study chemical processes in the condensed phase and in enzymes.

Lynn Kamerlin, Professor, Department of Cell and Molecular Biology, Uppsala University
Professor Kamerlin is a full?Professor?of Structural Biology at Uppsala University, as well as an ERC Starting Independent Researcher and a Wallenberg Academy Fellow. She is also the current Chair of the Young Academy of Europe (YAE). Her research interests span theoretical physical organic chemistry, phosphate and sulfate chemistry, the mechanisms of enzyme reactivity, specificity, promiscuity and catalysis, and computational directed evolution.

Fernanda Duarte, Department of Cell and Molecular Biology, Uppsala University
Dr Duarte is the Newton Fellow at University of Oxford, UK. In November 2015, she was awarded a ?100,000 grant for research into Plagiarizing Proteins: In Silico Evolution of Catalysts for Selective Chemical Synthesis.