Molecular Biology of Kinetoplastid Parasites

Kinetoplastid parasites are responsible for a number of serious protozoal diseases with limited treatment options and few commercially available vaccines. Viewed globally, these parasites pose an increasing threat to human health and welfare. Written by a team of authors active in the field of Leishmania and Trypanosoma research, this volume reviews the current research in kinetoplastid parasites. With an emphasis on cellular and molecular biology, areas covered include epigenetic regulation, cellular defence, manipulation of host macrophages, B lymphocyte response, adhesion and invasion of host tissues, immune evasion, immunotherapy, hemeproteins, phospholipids biosynthesis and DNA topoisomerases. A common theme throughout the book is the identification of new therapeutic targets for drug development. This timely and up-to-date volume is essential reading for anyone working on kinetoplastid parasites and will also be of interest to parasitologists, immunologists and drug development researchers. All parasitology laboratories should have a copy of this important reference volume.