Contemporary Accounts In Drug Discovery And Development

This book, through case studies of successful drug discoveries and launches, helps medicinal chemists and pharmaceutical scientists quickly master the necessary knowledge of the drug discovery process - including pharmacology, drug metabolism, biology, drug development, and clinical studies. The authors not only cover the full stories of marketed small molecule drugs, but also include drug candidates that have passed Phase I clinical trials with different modalities such as antibody drug conjugates (ADC), antibodies, and peptide drugs. Each chapter has detailed biological rational and background information, drug design principles, SAR development, ADMET considerations, and clinical studies, with modern drug discovery principles and technologies incorporated.